The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
Open accessAbstract
Yes-associated protein (YAP) is a potent transcription coactivator acting via binding to the TEAD transcription factor, and plays a critical role in organ size regulation. YAP is phosphorylated and inhibited by the Lats kinase, a key component of the Hippo tumor suppressor pathway. Elevated YAP protein levels and gene amplification have been implicated in human cancer. In this study, we report that YAP is inactivated during embryonic stem (ES) cell differentiation, as indicated by decreased protein levels and increased phosphorylation. Consistently, YAP is elevated during induced pluripotent stem (iPS) cell reprogramming. YAP knockdown leads to a loss of ES cell pluripotency, while ectopic expression of YAP prevents ES cell differentiation in vitro and maintains stem cell phenotypes even under differentiation conditions. Moreover, YAP binds directly to promoters of a large number of genes known to be important for stem cells and stimulates their expression. Our observations establish a critical role of YAP in maintaining stem cell pluripotency.
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Cites
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells
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Self-citationIn vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
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Polycomb complexes repress developmental regulators in murine embryonic stem cells
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TEAD mediates YAP-dependent gene induction and growth control
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Self-citation
Cited by
Hippo pathway in organ size control, tissue homeostasis, and cancer
Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell · doi:10.1016/j.cell.2015.10.044 · Cited by 2,206
Self-citationMechanisms of Hippo pathway regulation
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Self-citationThe Hippo pathway: regulators and regulations.
Yu, F.-X., & Guan, K.-L. (2013) · Genes & Development · doi:10.1101/gad.210773.112 · Cited by 1,231
Self-citationThe Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
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Self-citationYAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
Azzolin, L., Panciera, T., Soligo, S., Enzo, E., Bicciato, S., Dupont, S., Bresolin, S., Frasson, C., Basso, G., Guzzardo, V., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.013 · Cited by 1,094
Metadata
- Authors
- Lian, I., Kim, J., Okazawa, H., Zhao, J., Zhao, B., Yu, J., Chinnaiyan, A., Israel, M. A., Goldstein, L. S. B., Abujarour, R., Ding, S., & Guan, K.-L.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-06-01
- Volume
- 24
- Issue
- 11
- Pages
- 1106-1118
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2143076230
- Cited by
- 745
- References
- 60
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Lian, I., Kim, J., Okazawa, H., Zhao, J., Zhao, B., Yu, J., Chinnaiyan, A., Israel, M. A., Goldstein, L. S. B., Abujarour, R., Ding, S., & Guan, K.-L. (2010). The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes & Development. https://doi.org/10.1101/gad.1903310
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