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Cited by 265

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

A mutation in the Gsk3–binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon

Open access
Heisenberg, Carl-Philipp, Houart, Corinne, Take-uchi, Masaya, Rauch, Gerd-Jörg, Young, Neville, Coutinho, Pedro, Masai, Ichiro, Caneparo, Luca, Concha, Miguel L., Geisler, Robert, Dale, Trevor C., Wilson, Stephen W., Stemple, Derek L.·2001·Genes & Development
DOI 10.1101/gad.194301
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Abstract

Zebrafish embryos homozygous for the masterblind(mbl) mutation exhibit a striking phenotype in which the eyes and telencephalon are reduced or absent and diencephalic fates expand to the front of the brain. Here we show that mbl−/−embryos carry an amino-acid change at a conserved site in the Wnt pathway scaffolding protein, Axin1. The amino-acid substitution present in the mbl allele abolishes the binding of Axin to Gsk3 and affects Tcf-dependent transcription. Therefore, Gsk3 activity may be decreased in mbl−/− embryos and in support of this possibility, overexpression of either wild-type Axin1 or Gsk3β can restore eye and telencephalic fates to mbl−/−embryos. Our data reveal a crucial role for Axin1-dependent inhibition of the Wnt pathway in the early regional subdivision of the anterior neural plate into telencephalic, diencephalic, and eye-forming territories.

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Crossref · 10.1101/gad.194301

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Metadata

Authors
Heisenberg, C.-P., Houart, C., Take-uchi, M., Rauch, G.-J., Young, N., Coutinho, P., Masai, I., Caneparo, L., Concha, M. L., Geisler, R., Dale, T. C., Wilson, S. W., & Stemple, D. L.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
2001-06-01
Volume
15
Issue
11
Pages
1427-1434
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.194301
OpenAlex
W2143854875
Cited by
265
References
37
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: A mutation in the Gsk3–binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. https://app.cochat.ai/papers/10.1101/gad.194301
The paper
Heisenberg, C.-P., Houart, C., Take-uchi, M., Rauch, G.-J., Young, N., Coutinho, P., Masai, I., Caneparo, L., Concha, M. L., Geisler, R., Dale, T. C., Wilson, S. W., & Stemple, D. L. (2001). A mutation in the Gsk3–binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes & Development. https://doi.org/10.1101/gad.194301

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.