The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.
Open accessAbstract
Human AP-2 is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to stimulate transcription of selected genes. Here, we report the isolation and characterization of a human cDNA clone containing the entire protein-coding region of AP-2. The deduced primary amino acid sequence of AP-2 does not contain a domain resembling any previously identified DNA binding motif. However, an interesting feature of the AP-2 protein is a clustered arrangement of proline and glutamine residues that have been found recently within the activation domains of other transcription factors. Expression of the AP-2 clone in bacteria yields a protein that binds to DNA and activates transcription in vitro in a comparable manner to native human AP-2. Transfection of cDNA clones into Drosophila cells indicates that the AP-2 gene product can also activate gene expression in vivo in a DNA template-dependent manner. Expression of endogenous AP-2 is repressed in a hepatoma cell line and stimulated following retinoic-acid-induced differentiation of a human teratocarcinoma cell line. This indicates that AP-2 may be a transcription factor involved in the control of developmentally regulated gene expression.
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Cites
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
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A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
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Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements
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Cited by
REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN
Dalton, T. P., Shertzer, H. G., & Puga, A. (1999) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.67 · Cited by 1,118
Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.
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Self-citationAnalysis of the DNA-binding and activation properties of the human transcription factor AP-2.
Williams, T., & Tjian, R. (1991) · Genes & Development · doi:10.1101/gad.5.4.670 · Cited by 507
Self-citationFujita, T., Nolan, G. P., Liou, H. C., Scott, M. L., & Baltimore, D. (1993) · Genes & Development · doi:10.1101/gad.7.7b.1354 · Cited by 409
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Metadata
- Authors
- Williams, T., Admon, A., Luscher, B., & Tjian, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1988-12-01
- Volume
- 2
- Issue
- 12a
- Pages
- 1557-1569
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2045545244
- Cited by
- 573
- References
- 58
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Williams, T., Admon, A., Luscher, B., & Tjian, R. (1988). Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes & Development. https://doi.org/10.1101/gad.2.12a.1557
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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