The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers.
Open accessAbstract
The candidate proto-oncogene bcl-3 encodes a protein that shares structural features with I kappa B-alpha and other proteins that bind to members of the Rel protein family. Here, we show that in contrast to the inhibitory activity of I kappa B-alpha, the bcl-3 gene product superactivates NF-kappa B p50 homodimer-mediated gene expression both in vivo and in vitro. BCL-3 protein can, as well, selectively associate with p50 homodimers in the presence of DNA containing a kappa B motif. These results strongly suggest that BCL-3 can act as a transcriptional coactivator, acting through DNA-bound p50 homodimers.
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BCL3 represented the leading transcription factor for a majority of SASP genes.
“BCL3, a key transcriptional coactivator for NFKB31 (Supplementary Fig. 1b–c), represented the leading transcription factor for a majority of SASP genes (Supplementary Fig. 1d).”
From A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues (2022) · cites this paper as [31]
A major regulator of the SASP cells was the transcription factor BCL3, a key transcriptional coactivator for NFkB.
“Interestingly, and as predicted from the human RNA-seq data (Fig. 1b, Supplementary Fig. 1), a major regulator of the SASP cells was the transcription factor BCL3, a key transcriptional coactivator for NFkB31 (Supplementary Fig. 8a, b).”
From A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues (2022) · cites this paper as [31]
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- Authors
- Fujita, T., Nolan, G. P., Liou, H. C., Scott, M. L., & Baltimore, D.
- Affiliations
- Rockefeller University (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1993-07-01
- Volume
- 7
- Issue
- 7b
- Pages
- 1354-1363
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2122559781
- Cited by
- 409
- References
- 20
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 1 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 1 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 3 · 2014: 9 · 2013: 11 · 2012: 17
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion, cc-by)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Cancer Research Institute
- National Institutes of Health
- National Cancer Institute (R01CA051462, CA51462)
- National Institute of General Medical Sciences (R01GM039458, GM39458-04)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- Bcl-3, proto-oncogenes, transcriptional coactivator, IκBα, gene activation, protein-DNA interactions, superactivation
- MeSH terms
- B-Cell Lymphoma 3 Protein, Proto-Oncogene Mas, Animals, Cells, Cultured, DNA, Humans, Luciferases, Proto-Oncogene Proteins, Transcription Factors, Transcription, Genetic, Trans-Activators, Gene Expression, NF-kappa B, Mice
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