The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
The genomic landscapes of inflammation
Open accessAbstract
Inflammation involves the activation of a highly coordinated gene expression program that is specific for the initial stimulus and occurs in a different manner in bystander parenchymal cells and professional immune system cells recruited to the inflamed site. Recent data demonstrate that developmental transcription factors like the macrophage fate-determining Pu.1 set the stage for the activity of ubiquitous transcription factors activated by inflammatory stimuli, like NF-kB, AP-1, and interferon regulatory factors (IRFs). The intersection of lineage-determining and stimulus-activated transcription factors at enhancers explains cell type specificity in inflammatory responses.
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“In myeloid, dendritic, and B lineage cells, PU.1 is a major contributor to the positive regulation of genes that establish lineage-specific identity (4, 17, 19).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [17]
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Pattern Recognition Receptors and Inflammation
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Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618
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Histone modifications at human enhancers reflect global cell-type-specific gene expression
Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533
Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
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Pennacchio, L. A., Ahituv, N., Moses, A. M., Prabhakar, S., Nobrega, M. A., Shoukry, M., Minovitsky, S., Dubchak, I., Holt, A., Lewis, K. D., et al. (2006) · Nature · doi:10.1038/nature05295 · Cited by 1,165
Liver X receptors as integrators of metabolic and inflammatory signaling
Zelcer, N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27883 · Cited by 978
Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6
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A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers
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Research works printed but not linked: 1
- 1887, Sur la lutte des cellules de l'organisme contre l'invasion des microbes, Annales de l'Institut Pasteur, 1, 321
Cited by
Sorted by citations
Regulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442
Diversity, Mechanisms, and Significance of Macrophage Plasticity
Locati, M., Curtale, G., & Mantovani, A. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012718 · Cited by 2,199
Microglial brain region-dependent diversity and selective regional sensitivities to aging
Grabert, K., Michoel, T., Karavolos, M. H., Clohisey, S., Baillie, J. K., Stevens, M. P., Freeman, T. C., Summers, K. M., & McColl, B. W. (2016) · Nature Neuroscience · doi:10.1038/nn.4222 · Cited by 1,151
Latent Enhancers Activated by Stimulation in Differentiated Cells
Ostuni, R., Piccolo, V., Barozzi, I., Polletti, S., Termanini, A., Bonifacio, S., Curina, A., Prosperini, E., Ghisletti, S., & Natoli, G. (2013) · Cell · doi:10.1016/j.cell.2012.12.018 · Cited by 867
Self-citationMacrophage-Mediated Inflammation in Normal and Diabetic Wound Healing
Boniakowski, A. E., Kimball, A., Jacobs, B. N., Kunkel, S. L., & Gallagher, K. A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700223 · Cited by 564
Metadata
- Authors
- Natoli, G., Ghisletti, S., & Barozzi, I.
- Affiliations
- European Institute of Oncology (IT)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-01-15
- Volume
- 25
- Issue
- 2
- Pages
- 101-106
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC3022255
- OpenAlex
- W2005656449
- Cited by
- 152
- References
- 37
- Citations by year
- 2025: 6 · 2024: 3 · 2023: 11 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 11 · 2017: 10 · 2016: 9 · 2015: 14 · 2014: 19 · 2013: 15 · 2012: 10
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- inflammation, transcriptional programs, transcription factors, enhancers, PU.1, macrophage differentiation, NF-kB, AP-1, interferon regulatory factors, cell type specificity
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Inflammation, Macrophages, Transcription Factors, Genome
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