The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Aneuploidy causes proteotoxic stress in yeast
Open accessAbstract
Gains or losses of entire chromosomes lead to aneuploidy, a condition tolerated poorly in all eukaryotes analyzed to date. How aneuploidy affects organismal and cellular physiology is poorly understood. We found that aneuploid budding yeast cells are under proteotoxic stress. Aneuploid strains are prone to aggregation of endogenous proteins as well as of ectopically expressed hard-to-fold proteins such as those containing polyglutamine (polyQ) stretches. Protein aggregate formation in aneuploid yeast strains is likely due to limiting protein quality-control systems, since the proteasome and at least one chaperone family, Hsp90, are compromised in many aneuploid strains. The link between aneuploidy and the formation and persistence of protein aggregates could have important implications for diseases such as cancer and neurodegeneration.
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Cites
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Self-citationMisfolded proteins partition between two distinct quality control compartments
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Cited by
Widespread Proteome Remodeling and Aggregation in Aging C. elegans
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Cellular Handling of Protein Aggregates by Disaggregation Machines
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Gene Copy-Number Alterations: A Cost-Benefit Analysis
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Self-citationGene expression analysis identifies global gene dosage sensitivity in cancer
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Single cell sequencing reveals low levels of aneuploidy across mammalian tissues
Knouse, K. A., Wu, J., Whittaker, C. A., & Amon, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415287111 · Cited by 314
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Metadata
- Authors
- Oromendia, A. B., Dodgson, S. E., & Amon, A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-12-07
- Volume
- 26
- Issue
- 24
- Pages
- 2696-2708
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2140977472
- Cited by
- 313
- References
- 11
- Type
- posted content
- Language
- en
- Open access
- diamond
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