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Senataxin: A key actor in RNA metabolism, genome integrity and neurodegeneration

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ALS Yeast Models—Past Success Stories and New Opportunities

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Nuclear mRNA Surveillance Mechanisms: Function and Links to Human Disease

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Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation

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SUMOylation: A link to future therapeutics

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Facilitators and Repressors of Transcription‐coupled DNA Repair in Saccharomyces cerevisiae

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RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration

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The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA/DNA hybrids (R-loops)

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Searching the overlap between network modules with specific betweeness (S2B) and its application to cross-disease analysis

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Reciprocal Links between Pre-messenger RNA 3′-End Processing and Genome Stability

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Dissemination of the Flavivirus Subgenomic Replicon Genome and Viral Proteins by Extracellular Vesicles

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Effects of senataxin and RNA exosome on B-cell chromosomal integrity

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Transcription/Replication Conflicts in Tumorigenesis and Their Potential Role as Novel Therapeutic Targets in Multiple Myeloma

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A role for human senataxin in contending with pausing and backtracking during transcript elongation

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Break-induced replication is activated to repair R-loop-associated double-strand breaks in SETX-deficient cells

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C1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage response

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Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly

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Senataxin prevents replicative stress induced by the Myc oncogene

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A Novel Homozygous Variant of SETX Causes Ataxia with Oculomotor Apraxia Type 2

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Role of Senataxin in Amyotrophic Lateral Sclerosis

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Expression of targets of the RNA-binding protein AUF-1 in human airway epithelium indicates its role in cellular senescence and inflammation

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Drug-delivery and biological activity in colorectal cancer of a supramolecular porous material assembled from heptameric chromium-copper-adenine entities

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The Piwi-piRNA complex initiates transposon silencing via transcription termination factors PNUTS and Senataxin

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Multiple ways to a dead end: diverse mechanisms by which ALS mutant genes induce cell death

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Fateful Decisions of Where to Cut the Line: Pathology Associated with Aberrant 3′ End Processing and Transcription Termination

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Exosc9 Initiates SUMO-Dependent lncRNA TERRA Degradation to Impact Telomeric Integrity in Endocrine Therapy Insensitive Hormone Receptor-Positive Breast Cancer

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Nascent RNA at the crossroad of transcription and replication

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The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells

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Mechanisms underlining R-loop biology and implications for human disease

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Cellular imbalance of specific RNA-binding proteins associates with harmful R-loops

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Sen1: The Varied Virtues of a Multifaceted Helicase

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Senataxin Attenuates DNA Damage Response Activation and Suppresses Senescence

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Current and future therapeutic strategies to treat ataxia telangiectasia

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Senataxin: A Putative RNA: DNA Helicase Mutated in ALS4—Emerging Mechanisms of Genome Stability in Motor Neurons

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The SMC5/SMC6 complex is critical for resolving R-loop-induced transcription–replication conflicts

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The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loopsPreprint

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SETX sumoylation

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SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease

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Senataxin: A key actor in RNA metabolism, genome integrity and neurodegeneration

Giannini, M., & Porrúa, O. (2023) · Biochimie · doi:10.1016/j.biochi.2023.08.001 · Cited by 24 · see citing works

Senataxin, A Novel Helicase at the Interface of RNA Transcriptome Regulation and Neurobiology: From Normal Function to Pathological Roles in Motor Neuron Disease and Cerebellar Degeneration

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Exosomes with unique CNS-targeting properties brings novel therapeutic strategy to neuronopathic LDs

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