The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Origins, genetic landscape, and emerging therapies of small cell lung cancer
Open accessAbstract
Lung cancer is the leading cause of cancer deaths, with small cell lung cancer (SCLC) representing the most aggressive subtype. Standard treatments have not changed in decades, and the 5-year survival rate has remained <7%. Genomic analyses have identified key driver mutations of SCLC that were subsequently validated in animal models of SCLC. To provide better treatment options, a deeper understanding of the cellular and molecular mechanisms underlying SCLC initiation, progression, metastasis, and acquisition of resistance is required. In this review, we describe the genetic landscape of SCLC, features of the cell of origin, and targeted therapeutic approaches.
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Cites
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The retinoblastoma protein and cell cycle control
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RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
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Self-citationAnother fork in the road—life or death decisions by the tumour suppressor p53
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“The same model has also been used to test the efficacy of anti-apoptotic inhibitors both as single agents and in a combination regimen (Faber et al. 2015).”
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Cited by
Carter, L., Rothwell, D. G., Mesquita, B., Smowton, C., Leong, H. S., Fernandez-Gutierrez, F., Li, Y., Burt, D. J., Antonello, J., Morrow, C. J., et al. (2017) · Nature Medicine · doi:10.1038/nm.4239 · Cited by 308
Metadata
- Authors
- Semenova, E. A., Nagel, R., & Berns, A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-07-15
- Volume
- 29
- Issue
- 14
- Pages
- 1447-1462
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1923410233
- Cited by
- 250
- References
- 9
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Semenova, E. A., Nagel, R., & Berns, A. (2015). Origins, genetic landscape, and emerging therapies of small cell lung cancer. Genes & Development. https://doi.org/10.1101/gad.263145.115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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