Another fork in the road—life or death decisions by the tumour suppressor p53

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A model for p53-induced apoptosis

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Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

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Transcriptional control of human p53-regulated genes

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Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

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p53 Has a Direct Apoptogenic Role at the Mitochondria

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p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

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Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

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DNA damage induces phosphorylation of the amino terminus of p53

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Chk2/hCds1 functions as a DNA damage checkpoint in G₁by stabilizing p53

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p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

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p53 Dynamics Control Cell Fate

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Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

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p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

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Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

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Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiation

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

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NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcriptionPreprint

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ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

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The RNA polymerase II core promoter: a key component in the regulation of gene expressionPreprint

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Analysis of p53-regulated gene expression patterns using oligonucleotide arraysPreprint

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

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Transcriptional Regulation by P53

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PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53

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Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

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Coping with stress: multiple ways to activate p53

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Posttranslational Modification of p53: Cooperative Integrators of FunctionPreprint

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Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

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The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

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The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response

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ATM Mediates Phosphorylation at Multiple p53 Sites, Including Ser46, in Response to Ionizing Radiation

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DYRK2 Is Targeted to the Nucleus and Controls p53 via Ser46 Phosphorylation in the Apoptotic Response to DNA Damage

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Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate

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iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53

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p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

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Cell fate decision mediated by p53 pulses

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E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation

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ASPP1 and ASPP2: Common Activators of p53 Family Members

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Comparative Binding of p53 to its Promoter and DNA Recognition Elements

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Differential Transactivation by the p53 Transcription Factor Is Highly Dependent on p53 Level and Promoter Target Sequence

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The C-terminal lysines fine-tune p53 stress responses in a mouse model, but are not required for stability control or transactivation

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Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression

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MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis

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MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53

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hCAS/CSE1L Associates with Chromatin and Regulates Expression of Select p53 Target Genes

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Hzf Determines Cell Survival upon Genotoxic Stress by Modulating p53 Transactivation

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Ser18 and 23 phosphorylation is required for p53‐dependent apoptosis and tumor suppression

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The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

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Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression.

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Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53

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Ser46 Phosphorylation Regulates p53-Dependent Apoptosis and Replicative Senescence

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Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis

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Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53Preprint

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Acetylation of Mouse p53 at Lysine 317 Negatively Regulates p53 Apoptotic Activities after DNA Damage

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ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growthPreprint

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The prolyl-isomerase Pin1 activates the mitochondrial death program of p53

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Regulation of the p53 transcriptional response by structurally diverse core promoters

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DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage.

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p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts.

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Regulation of tissue‐ and stimulus‐specific cell fate decisions by p53 in vivo

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Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90

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P53 in survival, death and metabolic health: a lifeguard with a licence to kill.

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Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

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Cell Cycle Regulation by Checkpoints

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p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

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The Role of p53 Signaling in Colorectal Cancer

Liebl, M. C., & Hofmann, T. G. (2021) · Cancers · doi:10.3390/cancers13092125 · Cited by 332 · see citing works

Cell-to-cell variation in p53 dynamics leads to fractional killing.

Paek, A. L., Liu, J. C., Loewer, A., Forrester, W. C., & Lahav, G. (2016) · Cell · doi:10.1016/j.cell.2016.03.025 · Cited by 292 · see citing works

Smoking, p53 Mutation, and Lung Cancer

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Origins, genetic landscape, and emerging therapies of small cell lung cancerPreprint

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Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages

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Quantitative Phosphoproteomics of the Ataxia Telangiectasia-Mutated (ATM) and Ataxia Telangiectasia-Mutated and Rad3-related (ATR) Dependent DNA Damage Response in Arabidopsis thaliana*

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Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming

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The toxic effects of chlorophenols and associated mechanisms in fish

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Checkpoint Responses to DNA Double-Strand Breaks

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The role of DNA damage responses in p53 biology

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Caught in the cross fire: p53 in inflammation

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Genome Stability Requires p53

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Surviving apoptosis: life–death signaling in single cells

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New insights into small‐cell lung cancer development and therapy

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Emerging Roles of p53 Family Members in Glucose Metabolism

Itahana, Y., & Itahana, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030776 · Cited by 120 · see citing works

CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination

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Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53

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