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Mitochondrial biogenesis and dynamics in the developing and diseased heart
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The mitochondrion is a complex organelle that serves essential roles in energy transduction, ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network orchestrates the biogenesis, maintenance, and turnover of mitochondria. The high-capacity mitochondrial system in the heart is regulated in a dynamic way to generate and consume enormous amounts of ATP in order to support the constant pumping function in the context of changing energy demands. This review describes the regulatory circuitry and downstream events involved in mitochondrial biogenesis and its coordination with mitochondrial dynamics in developing and diseased hearts.
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“mitochondrial biogenesis is responsible for oxidative phosphorylation and fatty acid β-oxidation [31].”
From A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity (2022) · cites this paper as [31]
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Metadata
- Authors
- Dorn, G. W., Vega, R. B., & Kelly, D. P.
- Affiliations
- Washington University in St. Louis (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-10-01
- Volume
- 29
- Issue
- 19
- Pages
- 1981-1991
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC4604339
- OpenAlex
- W2267961811
- Cited by
- 470
- References
- 106
- Citations by year
- 2026: 32 · 2025: 38 · 2024: 53 · 2023: 59 · 2022: 54 · 2021: 76 · 2020: 46 · 2019: 36 · 2018: 25 · 2017: 29 · 2016: 21
- Type
- posted content
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Genes & Development (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- Funders
- National Institutes of Health (R01 DK045416, R01 HL058493, R01 HL59888, R01 HL128071)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- mitochondrial biogenesis, mitochondrial dynamics, heart development, heart disease, mitochondrial turnover, myocardial energy metabolism, ATP production, mitochondrial regulation
- MeSH terms
- Animals, Organelle Biogenesis, Heart, Heart Diseases, Humans, Mitochondria, Myocardium, Transcription Factors, Mitophagy
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