Cited by 471Mitochondrial Function and PathologyAutophagy in Disease and TherapyCongenital heart defects research

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Mitochondrial biogenesis and dynamics in the developing and diseased heart

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Dorn, Gerald W., Vega, Rick B., Kelly, Daniel P.·2015·Genes & Development

DOI 10.1101/gad.269894.115PMC PMC4604339

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Abstract

The mitochondrion is a complex organelle that serves essential roles in energy transduction, ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network orchestrates the biogenesis, maintenance, and turnover of mitochondria. The high-capacity mitochondrial system in the heart is regulated in a dynamic way to generate and consume enormous amounts of ATP in order to support the constant pumping function in the context of changing energy demands. This review describes the regulatory circuitry and downstream events involved in mitochondrial biogenesis and its coordination with mitochondrial dynamics in developing and diseased hearts.

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Authors: Dorn, G. W., Vega, R. B., & Kelly, D. P.
Affiliations: Washington University in St. Louis (US)
Sanford Burnham Prebys Medical Discovery Institute (US)
ORCID: Dorn, Gerald W.
Vega, Rick B.
Kelly, Daniel P.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2015-10-01
Volume: 29
Issue: 19
Pages: 1981-1991
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.269894.115
PMC: PMC4604339
OpenAlex: W2267961811
Cited by: 470
References: 106
Citations by year: 2026: 32 · 2025: 38 · 2024: 53 · 2023: 59 · 2022: 54 · 2021: 76 · 2020: 46 · 2019: 36 · 2018: 25 · 2017: 29 · 2016: 21
Type: posted content
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Genes & Development (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
Funders: National Institutes of Health (R01 DK045416, R01 HL058493, R01 HL59888, R01 HL128071)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: mitochondrial biogenesis, mitochondrial dynamics, heart development, heart disease, mitochondrial turnover, myocardial energy metabolism, ATP production, mitochondrial regulation
MeSH terms: Animals, Organelle Biogenesis, Heart, Heart Diseases, Humans, Mitochondria, Myocardium, Transcription Factors, Mitophagy

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Mitochondrial biogenesis and dynamics in the developing and diseased heart

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