PRKCI promotes immune suppression in ovarian cancer

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Protein kinase C signaling “in” and “to” the nucleus: Master kinases in transcriptional regulation

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Emerging roles of the Hippo signaling pathway in modulating immune response and inflammation‐driven tissue repair and remodeling

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Protein Kinase C (PKC) Isozymes as Diagnostic and Prognostic Biomarkers and Therapeutic Targets for Cancer

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Genomic Characterization of de novo Metastatic Breast Cancer

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An Updated Understanding of the Role of YAP in Driving Oncogenic Responses

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YAP/Hippo Pathway and Cancer Immunity: It Takes Two to Tango

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Addiction to protein kinase Cɩ due to PRKCI gene amplification can be exploited for an aptamer-based targeted therapy in ovarian cancer

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The role of YAP1 in survival prediction, immune modulation, and drug response: A pan-cancer perspective

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Intratumoral collagen signatures predict clinical outcomes in feline mammary carcinoma

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Impact of cancer cell-intrinsic features on neutrophil behavior

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Protein kinase Cι mediates immunosuppression in lung adenocarcinoma

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Transcriptome Analysis of Ovarian and Uterine Clear Cell Malignancies

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Specific targeting of cancer stem cells by immunotherapy: A possible stratagem to restrain cancer recurrence and metastasis

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Evaluating the current status of protein kinase C (PKC)-protein kinase D (PKD) signalling axis as a novel therapeutic target in ovarian cancer

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Whole transcriptome analysis reveals non-coding RNA's competing endogenous gene pairs as novel form of motifs in serous ovarian cancer

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Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions

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Multidimensional analysis of tumor stem cells: from biological properties, metabolic adaptations to immune escape mechanisms

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Multisite analysis of high‐grade serous epithelial ovarian cancers identifies genomic regions of focal and recurrent copy number alteration in 3q26.2 and 8q24.3

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Lambda-Carrageenan Enhances the Effects of Radiation Therapy in Cancer Treatment by Suppressing Cancer Cell Invasion and Metastasis through Racgap1 Inhibition

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Protein kinase C-iota-mediated glycolysis promotes non-small-cell lung cancer progression

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Pan-Cancer Study on Protein Kinase C Family as a Potential Biomarker for the Tumors Immune Landscape and the Response to Immunotherapy

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Protein Kinase C at the Crossroad of Mutations, Cancer, Targeted Therapy and Immune Response

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Prophylactic In Vivo Hematopoietic Stem Cell Gene Therapy with an Immune Checkpoint Inhibitor Reverses Tumor Growth in Syngeneic Mouse Tumor Models

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Genome-Wide CRISPR Screen Identifies Host Factors Required by Toxoplasma gondii Infection

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Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice

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Transcription factor Sp1 is upregulated by PKCι to drive the expression of YAP1 during pancreatic carcinogenesis

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Hippo Pathway Activation in Aged Mesenchymal Stem Cells Contributes to the Dysregulation of Hepatic Inflammation in Aged Mice

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Modulation of the Hippo pathway and organ growth by RNA processing proteins

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Epigenome-wide DNA methylation in unipolar depression: predictive biomarker of antidepressant treatment response?

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BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling

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PKCα inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability

Yu, J.-J., Xiang, Y., Gao, Y.-Z., Chang, S., Kong, R., Lv, X.-X., Yu, J.-M., Jin, Y., Li, C.-X., Ma, Y.-R., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.08.003 · Cited by 12 · see citing works

Clinical Significance of PRKCI Gene Expression in Cancerous Tissue in Patients With Gastric Cancer

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Oncogenic protein kinase Cι signaling mechanisms in lung cancer: Implications for improved therapeutic strategies

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CircRNAs: Roles in regulating head and neck squamous cell carcinoma

Han, X., Tian, R., Wang, C., Li, Y., & Song, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1026073 · Cited by 10 · see citing works

Recurrent copy number gains drive PKCι expression and PKCι-dependent oncogenic signaling in human cancers

Liu, Y., Justilien, V., Fields, A. P., & Murray, N. R. (2020) · Advances in Biological Regulation · doi:10.1016/j.jbior.2020.100754 · Cited by 10 · see citing works

miR-155 facilitates the synergistic replication between avian leukosis virus subgroup J and reticuloendotheliosis virus by targeting a dual pathway

Xue, J., Zhou, D., Zhou, J., Du, X., Zhang, X., Liu, X., Ding, L., & Cheng, Z. (2023) · Journal of Virology · doi:10.1128/jvi.00937-23 · Cited by 9 · see citing works

PKCι regulates the expression of PDL1 through multiple pathways to modulate immune suppression of pancreatic cancer cells

Zhang, H., Zhu, Y., Wang, J., Weng, S., Zuo, F., Li, C., & Zhu, T. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110115 · Cited by 8 · see citing works

Correlation of Yes-Associated Protein 1 with Stroma Type and Tumor Stiffness in Hormone-Receptor Positive Breast Cancer

Lee, Y., Bae, S. J., Eun, N. L., Ahn, S. G., Jeong, J., & Cha, Y. J. (2022) · Cancers · doi:10.3390/cancers14204971 · Cited by 8 · see citing works

Amplified therapeutic targets in high-grade serous ovarian carcinoma – a review of the literature with quantitative appraisal

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Establishment of multifactor predictive models for the occurrence and progression of cervical intraepithelial neoplasia

Chen, M., Wang, H., Liang, Y., Hu, M., & Li, L. (2020) · BMC Cancer · doi:10.1186/s12885-020-07265-7 · Cited by 7 · see citing works

Cellular polarity pilots breast cancer progression and immunosuppression

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Downregulation of PRKCI inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway

Qu, L., Yu, X., Feng, J., Ren, X., Li, Z., Chen, X., Miao, G., Chen, J., Sun, C., & Lu, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1389136 · Cited by 6 · see citing works

Joining Forces: Improving Clinical Response to Cellular Immunotherapies with Small-Molecule Inhibitors

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Finding Biomarkers from a High-Dimensional Imbalanced Dataset Using the Hybrid Method of Random Undersampling and Lasso

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Comprehensive analysis and molecular map of Hippo signaling pathway in lower grade glioma: the perspective toward immune microenvironment and prognosis

Guo, Y., Sun, J., Zhao, C., Han, L., Yu, C., & Zhang, H. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1198414 · Cited by 4 · see citing works

miR-630 as a therapeutic target in pancreatic cancer stem cells: modulation of the PRKCI-Hedgehog signaling axis

Zou, J., Yang, S., He, C., Deng, L., Xu, B., & Chen, D. (2024) · Biology Direct · doi:10.1186/s13062-024-00539-1 · Cited by 4 · see citing works

Immunogenomic precision medicine: a personalized approach based on immunogenomic cancer evolution

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Cancer-cell-intrinsic mechanisms regulate MDSCs through cytokine networks

Zhang, Y., Murphy, S. P., & Lü, X. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.09.001 · Cited by 4 · see citing works

Prkci promotes colorectal cancer metastasis by phosphorylating and stabilizing Tgfbr1 to activate TGF-β signaling

Li, P., Liu, G., Zhang, W., & Li, T. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02236-6 · Cited by 3 · see citing works

Evolutionary dependency of cancer mutations in gene pairs inferred by nonsynonymous-synonymous mutation ratios

Han, D., Kim, S., Lee, S., Moon, Y., Kang, S. J., Yoo, J., Jeong, H. Y., Cho, H. J., Jeon, J. Y., Sim, B. C., et al. (2024) · Genome Medicine · doi:10.1186/s13073-024-01376-7 · Cited by 3 · see citing works

Defining the Role of Metastasis-Initiating Cells in Promoting Carcinogenesis in Ovarian Cancer

Wang, J., Ford, J. C., & Mitra, A. K. (2023) · Biology · doi:10.3390/biology12121492 · Cited by 5 · see citing works

Protein kinase Cι dictates tumor trajectory, cell plasticity, and immune surveillance in lung adenocarcinoma

Nguyen, D. T., Prieto, L. I., Zhang, C., Li, H., Khoór, A., Weems, C. R., Jamieson, L., Jeganathan, K. B., Babu, S. R., Murray, N. R., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116606 · Cited by 2 · see citing works

MK886 ameliorates Alzheimer's disease by activating the PRKCI/AKT signaling pathway

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Key players of immunosuppression in epithelial malignancies: Tumor‐infiltrating myeloid cells and γδ T cells

Tamuli, B., Sharma, S., Patkar, M., & Biswas, S. (2024) · Cancer Reports · doi:10.1002/cnr2.2066 · Cited by 2 · see citing works

Association of PKCi variant and its gene expression with breast cancer prognosisPreprint

Shah, H., Khan, K., Badshah, Y., Trembley, J. H., Ashraf, N. M., Shabbir, M., Afsar, T., Almajwal, A. M., & Razak, S. (2022) · Research Square · doi:10.21203/rs.3.rs-2299569/v1 · Cited by 2 · see citing works

YAP/TAZ activation in fibroblasts coordinates fibrotic remodeling, fibroinflammation, and epithelial dysfunction in pulmonary fibrosisPreprint

Mia, M. M., Selvan, A., Nilanthi, U., & Singh, M. K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.23.661212 · Cited by 2 · see citing works

Unravelling the role of PRKCI and key-cancer related genes in breast cancer development and metastasis

Shah, H., Khan, K., Badshah, Y., Trembley, J. H., Ashraf, N. M., Shabbir, M., Afsar, T., Aldisi, D. A., Khan, D., & Razak, S. (2025) · Discover Oncology · doi:10.1007/s12672-025-02133-x · Cited by 1 · see citing works

A novel mitochondrial autophagy and aging-related gene signature for predicting ovarian cancer

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Leveraging Real-World Data From a Clinicogenomic Database Addresses the Treatment Gap in Patients With High-Grade Serous Ovarian Cancer

Ciniselli, C. M., Conca, E., Bartoletti, M., Colombo, N., Malapelle, U., Lopez, S., Pignata, S., Raspagliesi, F., Verderio, P., Zamagni, C., et al. (2025) · JCO Precision Oncology · doi:10.1200/po-24-00832 · Cited by 1 · see citing works

Protein kinase Cι-driven macrophage infiltration mediates immunosuppression in non-small cell lung cancer

Hu, S., Zhao, Z., Zhao, J., Liang, Y., Zeng, L., Xia, Y., Guo, H., Jiang, L., & Zhang, Y. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218330 · Cited by 1 · see citing works

Neuronal and Glial YAP/TAZ in the Spinal Cord Contribute to the Development of Bone Cancer Pain in Mice

Peng, B., Lin, X., Hu, J.-J., Liao, H., Cheng, L., Li, Z., & Song, X. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-026-01607-4 · Cited by 1 · see citing works

Transcriptome-based protein-protein interaction analysis reveals immune gene network elucidating white body immunity mechanisms in response to LPS stimulation in Amphioctopus fangsiao

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Conceptual and Developmental Analysis of Mental Models: An Example with Complex Change Problems.

Poirier, L. (1994)

Circular RNA’s competing endogenous gene pair as motif in serous ovarian cancerPreprint

Li, H., Zheng, X., Zhang, N., Gao, J., Leung, K., Wong, M., Yang, S., Liu, Y., Dong, M., Bai, H., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.04.486923

Research Progress of Hippo Signaling Pathway and Human Immune Regulation

苟, 洪. (2022) · Hans Journal of Biomedicine · doi:10.12677/hjbm.2022.122017

Data from Genomic Characterization of de novo Metastatic Breast Cancer

Garrido-Castro, A. C., Spurr, L. F., Hughes, M. E., Li, Y. Y., Cherniack, A. D., Kumari, P., Lloyd, M. R., Bychkovsky, B., Barroso‐Sousa, R., Lascio, S. D., et al. (2023) · doi:10.1158/1078-0432.c.6530003

Additional file 3 of circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway

Gao, W., Guo, H., Niu, M., Zheng, X., Zhang, Y., Xue, X., Bo, Y., Guan, X., Li, Z., Guo, Y., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13285013

Additional file 1 of circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway

Gao, W., Guo, H., Niu, M., Zheng, X., Zhang, Y., Xue, X., Bo, Y., Guan, X., Li, Z., Guo, Y., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13285007

TEAD inhibition alters the lung immune microenvironment and attenuates metastasisPreprint

Rahhal, R., Schmidt, M. O., Moussa, M., Asemi, T., Battina, R., Kiliti, A. J., Wellstein, A., Riegel, A. T., & Sharif, G. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.26.639326

Additional file 3 of Establishment of multifactor predictive models for the occurrence and progression of cervical intraepithelial neoplasia

Chen, M., Wang, H., Liang, Y., Hu, M., & Li, L. (2020) · Figshare · doi:10.6084/m9.figshare.13023797

Additional file 1 of Evolutionary dependency of cancer mutations in gene pairs inferred by nonsynonymous-synonymous mutation ratios

Han, D.-J., Kim, S., Lee, S.-Y., Moon, Y., Kang, S. J., Yoo, J., Jeong, H. Y., Cho, H. J., Jeon, J. Y., Sim, B. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26785991

Additional file 2 of circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway

Gao, W., Guo, H., Niu, M., Zheng, X., Zhang, Y., Xue, X., Bo, Y., Guan, X., Li, Z., Guo, Y., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13285010

Additional file 2 of Evolutionary dependency of cancer mutations in gene pairs inferred by nonsynonymous-synonymous mutation ratios

Han, D.-J., Kim, S., Lee, S.-Y., Moon, Y., Kang, S. J., Yoo, J., Jeong, H. Y., Cho, H. J., Jeon, J. Y., Sim, B. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26786035

Additional file 1 of Establishment of multifactor predictive models for the occurrence and progression of cervical intraepithelial neoplasia

Chen, M., Wang, H., Liang, Y., Hu, M., & Li, L. (2020) · Figshare · doi:10.6084/m9.figshare.13023791

GARD: Genomic Data-Based Drug Repurposing in Head and Neck Cancer with Large Language Model Validation

Tanikella, P., Nenad, W. C., Courtine, C., Dai, Y., Deng, Q., Zou, B., Osazuwa‐Peters, N., Schrank, T. P., & Wu, D. (2026) · Cancers · doi:10.3390/cancers18050757

The role of Hippo pathway in cancer progression: Implications for cancer stem cells and EMT

Han, X., Wang, L., Li, Y., & Wang, Y. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189621

Genomic, Trop‐2, and Immune Profiles of Carcinomatous and Sarcomatous Components in Ovarian Carcinosarcoma

Sakamaki, T., Chiyoda, T., Nakamura, K., Takamatsu, R., Kawano, R., Ochiai, D., Jisaka, M., Takahashi, M., Yoshimura, T., Kimura, Y., et al. (2026) · Cancer Reports · doi:10.1002/cnr2.70659

PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis

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The dynamic immune behavior of primary and metastatic ovarian carcinoma

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Impaired Th1 immunity in ovarian cancer patients is mediated by TNFR2+ Tregs within the tumor microenvironment

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Ovarian cancer cell glucocorticoid receptor activation increases myeloid-derived suppressor cell tumor infiltration

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Abstract 1335: Ovarian cancer cell glucocorticoid receptor activity is associated with cytokine secretion promoting infiltration of immunosuppressive cells into the tumor microenvironment

Taya, M., Gonzalez, J., Bennett, L. B., & Conzen, S. D. (2022) · Cancer Research · doi:10.1158/1538-7445.am2022-1335