The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Necroptosis in development and diseases
Open accessAbstract
Necroptosis, a form of regulated necrotic cell death mediated by RIPK1 (receptor-interacting protein kinase 1) kinase activity, RIPK3, and MLKL (mixed-lineage kinase domain-like pseudokinase), can be activated under apoptosis-deficient conditions. Modulating the activation of RIPK1 by ubiquitination and phosphorylation is critical to control both necroptosis and apoptosis. Mutant mice with kinase-dead RIPK1 or RIPK3 and MLKL deficiency show no detrimental phenotype in regard to development and adult homeostasis. However, necroptosis and apoptosis can be activated in response to various mutations that result in the abortion of the defective embryos and human inflammatory and neurodegenerative pathologies. RIPK1 inhibition represents a key therapeutic strategy for treatment of diseases where blocking both necroptosis and apoptosis can be beneficial.
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Cites
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Self-citationRIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
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“…long isoform FLIPL forms a heterodimeric complex with caspase-8 in which the latter is partially active and inhibits RIPK1-dependent cell death (Oberst et al. 2011), short isoform FLIPS forms caspase-8 heterodimers completely devoid of catalytic activity, promoting RIPK1 kinase activation and…”
BackgroundMutations of optineurin in amyotrophic lateral sclerosis
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Cited by
Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
Yuan, J., Amin, P., & Ofengeim, D. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0093-1 · Cited by 967
Self-citationMetal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355
The interplay of autophagy and non-apoptotic cell death pathways
(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.12.004 · Cited by 50
Kamiya, M., Kimura, N., Umezawa, N., Hasegawa, H., & Yasuda, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1191815 · Cited by 21
Xie, Y., Chen, H., Luo, D., Yang, X., Yao, J., Zhang, C., Lv, L., Guo, Z., Deng, C., Li, Y., et al. (2020) · Stem Cells and Development · doi:10.1089/scd.2019.0220 · Cited by 19
Metadata
- Authors
- Shan, B., Pan, H., Najafov, A., & Yuan, J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2018-03-01
- Volume
- 32
- Issue
- 5-6
- Pages
- 327-340
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2795155279
- Cited by
- 347
- References
- 28
- Type
- posted content
- Language
- en
- Open access
- diamond
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