Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

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CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

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Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

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Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

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RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

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RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

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TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

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Axon degeneration: Molecular mechanisms of a self-destruction pathway

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RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

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Microglia and Inflammation in Alzheimers Disease

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The “Dying-Back” Phenomenon of Motor Neurons in ALS

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Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

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RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease

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Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice

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Neuroinflammation: Microglia and T Cells Get Ready to Tango

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Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

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TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

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MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

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Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives

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Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 ( DNL747 ) for neurodegenerative disorders: Randomized, placebo‐controlled , double‐blind phase I/Ib studies in healthy subjects and patients

Vissers, M. F. J. M., Heuberger, J. A. A. C., Groeneveld, G. J., Nijhuis, J. O., Deyn, P. P. D., Hadi, S., Harris, J. M., Tsai, R. M., Cruz-Herranz, A., Huang, F., et al. (2022) · Clinical and Translational Science · doi:10.1111/cts.13317 · Cited by 114 · see citing works

Different types of cell death in diabetic endothelial dysfunction

Shen, J., San, W., Zheng, Y., Zhang, S., Cao, D., Chen, Y., & Meng, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115802 · Cited by 114 · see citing works

Neuroimmune Mechanisms Underlying Neuropathic Pain: The Potential Role of TNF-α-Necroptosis Pathway

Duan, Y.-W., Chen, S., Li, Q., & Zang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137191 · Cited by 116 · see citing works

The pseudokinase MLKL regulates hepatic insulin sensitivity independently of inflammation

Xu, H., Du, X., Liu, G., Huang, S., Du, W., Zou, S., Tang, D., Fan, C., Xie, Y., Wei, Y., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.02.003 · Cited by 109 · see citing works

Research trends, hot spots and prospects for necroptosis in the field of neuroscience

Xiong, K., Yan, W., Lu, S., Yang, Y., Ning, W.-Y., Cai, Y., Hu, X.-M., & Zhāng, Q. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.303032 · Cited by 107 · see citing works

Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress

Mohammed, S., Nicklas, E. H., Thadathil, N., Selvarani, R., Royce, G. H., Kinter, M. T., Richardson, A. G., & Deepa, S. S. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.449 · Cited by 108 · see citing works

Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury

Qin, Q., Yu, N., Gu, Y., Ke, W., Zhang, Q., Liu, X., Wang, K., & Chen, M. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04911-9 · Cited by 108 · see citing works

Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter

Picón, C., Jayaraman, A., James, R., Beck, C., Gallego, P., Witte, M. E., van Horssen, J., Mazarakis, N. D., & Reynolds, R. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02274-7 · Cited by 108 · see citing works

Current translational potential and underlying molecular mechanisms of necroptosis

Molnár, T., Mázló, A., Tslaf, V., Szöllősi, A. G., Emri, G., & Koncz, G. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2094-z · Cited by 107 · see citing works

Deep Generative Models in De Novo Drug Molecule Generation

Pang, C., Qiao, J., Zeng, X., Zou, Q., & Wei, L. (2023) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.3c01496 · Cited by 107 · see citing works

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

Tao, L., Yi, Y., Chen, Y., Zhang, H., Jie, J., Zhang, W., Xu, Q., Li, Y., Ørning, P., Lien, E., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00668-w · Cited by 105 · see citing works

Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration

Zhou, S., Zhang, W., Cai, G., Ding, Y., Wei, C., Li, S., Yu, Y., Qin, J., Liu, D., Zhang, H., et al. (2020) · Cell Research · doi:10.1038/s41422-020-00393-6 · Cited by 104 · see citing works

Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners

Li, X., Zhang, M., Huang, X., Liang, W. P., Li, G., Lu, X., Li, Y., Pan, H., Shi, L., Zhu, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19935-y · Cited by 99 · see citing works

An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events

Cordaro, M., Cuzzocrea, S., & Crupi, R. (2020) · Antioxidants · doi:10.3390/antiox9030216 · Cited by 98 · see citing works

3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury

Zhang, H., Ni, W., Yu, G., Geng, Y., Lou, J., Qi, J., Chen, Y., Li, F., Ye, H., Ma, H., et al. (2023) · Theranostics · doi:10.7150/thno.78370 · Cited by 96 · see citing works

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

Harris, P. A., Marinis, J. M., Lich, J. D., Berger, S. B., Chirala, A., Cox, J. A., Eidam, P. M., Finger, J. N., Gough, P. J., Jeong, J. U., et al. (2019) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.9b00108 · Cited by 95 · see citing works

Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases

Hazafa, A., Batool, A., Ahmad, S., Amjad, M., Chaudhry, S. N., Asad, J., Ghuman, H. F., Khan, H. M., Naeem, M., & Ghani, U. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118679 · Cited by 96 · see citing works

SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation

Xu, G., Li, Y., Zhang, S., Peng, H., Wang, Y., Li, D., Jin, T., He, Z., Tong, Y., Qi, C., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00578-7 · Cited by 95 · see citing works

Signaling cascades in the failing heart and emerging therapeutic strategies

He, X., Du, T., Long, T., Liao, X., Dong, Y., & Huang, Z. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00972-6 · Cited by 105 · see citing works

RIPK protein kinase family: Atypical lives of typical kinases

Cuny, G. D., & Degterev, A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.06.014 · Cited by 94 · see citing works

Mechanisms of immune response and cell death in ischemic stroke and their regulation by natural compounds

Gong, Z., Guo, J., Liu, B., Guo, Y., Cheng, C., Jiang, Y., Liang, N., Hu, M., Song, T., Yang, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1287857 · Cited by 92 · see citing works

RIPK3 signaling and its role in regulated cell death and diseases

Zhou, Y., Xiang, Y., Liu, S., Li, C., Dong, J., Kong, X., Ji, X., Cheng, X., & Zhang, L. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01957-w · Cited by 94 · see citing works

Astrocyte-Mediated Neuroinflammation in Neurological Conditions

Zhao, Y., Huang, Y., Cao, Y., & Yang, J. H. (2024) · Biomolecules · doi:10.3390/biom14101204 · Cited by 100 · see citing works

Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB

Chou, T.-W., Chang, N. P., Krishnagiri, M., Patel, A. P., Lindman, M., Angel, J. P., Kung, P.-L., Atkins, C., & Daniels, B. P. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04049-0 · Cited by 90 · see citing works

Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death

Clucas, J., & Meier, P. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00623-w · Cited by 92 · see citing works

Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice

Papazian, I., Tsoukala, E., Boutou, A., Καραμίτα, Μ., Kambas, K., Iliopoulou, L., Fischer, R., Kontermann, R. E., Denis, M. C., Kollias, G. A., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02200-4 · Cited by 86 · see citing works

Ultrasmall iron oxide nanoparticles induced ferroptosis via Beclin1/ATG5-dependent autophagy pathway

Wen, J., Chen, H., Ren, Z., Zhang, P., Chen, J., & Jiang, S. (2021) · Nano Convergence · doi:10.1186/s40580-021-00260-z · Cited by 86 · see citing works

Identification and Validation a Necroptosis‑related Prognostic Signature and Associated Regulatory Axis in Stomach Adenocarcinoma

Wang, N., & Liu, D. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s342613 · Cited by 85 · see citing works

Targets to watch in neuroinflammation: focus on RIPK1

Romano, M. (2022) · Drugs of the Future · doi:10.1358/dof.2022.47.5.3391879 · Cited by 1 · see citing works

Necroptosis: A Novel Pathway in Neuroinflammation

Yu, Z., Jiang, N., Su, W., & Zhuo, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.701564 · Cited by 133 · see citing works

Viral-induced neuronal necroptosis: Detrimental to brain function and regulation by necroptosis inhibitors

Panda, S. P., Kesharwani, A., Mallick, S. P., Prasanth, D., Pasala, P. K., & Tatipamula, V. B. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115591 · Cited by 18 · see citing works

From RIPK1 to Necroptosis: Pathogenic Mechanisms in Neurodegenerative Diseases

Kang, A., Qiao, Y., Pan, S., Yan, F., Chen, H., & Bai, Y. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04448-1 · Cited by 16 · see citing works

Necroptosis in neurodegenerative disorders

Roy, T., Chatterjee, A., & Swarnakar, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-32852-7.00014-0