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Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression
Open accessAbstract
We have generated mice with a floxed fak allele under the control of keratin-14-driven Cre fused to a modified estrogen receptor (Cre ER T2). 4-Hydroxy-tamoxifen treatment induced fak deletion in the epidermis, and suppressed chemically induced skin tumor formation. Loss of fak induced once benign tumors had formed inhibited malignant progression. Although fak deletion was associated with reduced migration of keratinocytes in vitro, we found no effect on wound re-epithelialization in vivo. However, increased keratinocyte cell death was observed after fak deletion in vitro and in vivo. Our work provides the first experimental proof implicating FAK in tumorigenesis, and this is associated with enhanced apoptosis.
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Citations
Cited by
Tensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941
FAK in cancer: mechanistic findings and clinical applications
Sulzmaier, F. J., Jean, C., & Schlaepfer, D. D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3792 · Cited by 1,381
Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling
Wong, V. W., Rustad, K. C., Akaishi, S., Sorkin, M., Glotzbach, J. P., Januszyk, M., Nelson, E. R., Levi, K., Paterno, J., Vial, I. N., et al. (2012) · Nature Medicine · doi:10.1038/nm.2574 · Cited by 515
Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity
Serrels, A., Lund, T., Serrels, B., Byron, A., McPherson, R. C., von Kriegsheim, A., Gómez-Cuadrado, L., Canel, M., Muir, M., Ring, J. E., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.001 · Cited by 407
Self-citationCell-Extracellular Matrix Interactions in Normal and Diseased Skin
Watt, F. M., & Fujiwara, H. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005124 · Cited by 384
Metadata
- Authors
- McLean, G. W., Komiyama, N. H., Serrels, B., Asano, H., Reynolds, L., Conti, F., Hodivala-Dilke, K., Metzger, D., Chambon, P., Grant, S. G. N., & Frame, M. C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-12-15
- Volume
- 18
- Issue
- 24
- Pages
- 2998-3003
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2113551776
- Cited by
- 223
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. https://app.cochat.ai/papers/10.1101/gad.316304
- The paper
- McLean, G. W., Komiyama, N. H., Serrels, B., Asano, H., Reynolds, L., Conti, F., Hodivala-Dilke, K., Metzger, D., Chambon, P., Grant, S. G. N., & Frame, M. C. (2004). Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes & Development. https://doi.org/10.1101/gad.316304
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