The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Canalization of auxin flow by Aux/IAA-ARF-dependent feedback regulation of PIN polarity
Open accessAbstract
Plant development is characterized by a profound ability to regenerate and form tissues with new axes of polarity. An unsolved question concerns how the position within a tissue and cues from neighboring cells are integrated to specify the polarity of individual cells. The canalization hypothesis proposes a feedback effect of the phytohormone auxin on the directionality of intercellular auxin flow as a means to polarize tissues. Here we identify a cellular and molecular mechanism for canalization. Local auxin application, wounding, or auxin accumulation during de novo organ formation lead to rearrangements in the subcellular polar localization of PIN auxin transport components. This auxin effect on PIN polarity is cell-specific, does not depend on PIN transcription, and involves the Aux/IAA-ARF (indole-3-acetic acid-auxin response factor) signaling pathway. Our data suggest that auxin acts as polarizing cue, which links individual cell polarity with tissue and organ polarity through control of PIN polar targeting. This feedback regulation provides a conceptual framework for polarization during multiple regenerative and patterning processes in plants.
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“the expression of PIN proteins precedes vascular development (Sauer et al., 2006; Scarpella et al., 2006; Wenzel et al., 2007)”
From Shaping plant architecture (2015) · cites this paper as Sauer et al., 2006
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Cites
Local, Efflux-Dependent Auxin Gradients as a Common Module for Plant Organ Formation
Benková, E., Michniewicz, M., Sauer, M., Teichmann, T., Seifertová, D., Jürgens, G., & Friml, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00924-3 · Cited by 2,637
Self-citationAuxin: Regulation, Action, and Interaction
Woodward, A. W. (2005) · Annals of Botany · doi:10.1093/aob/mci083 · Cited by 2,399
The F-box protein TIR1 is an auxin receptor
Dharmasiri, N., Dharmasiri, S., & Estelle, M. (2005) · Nature · doi:10.1038/nature03543 · Cited by 2,083
The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots
Blilou, I., Xu, J., Wildwater, M., Willemsen, V., Paponov, I. A., Friml, J., Heidstra, R., Aida, M., Palme, K. J., & Scheres, B. (2005) · Nature · doi:10.1038/nature03184 · Cited by 2,061
Self-citationEfflux-dependent auxin gradients establish the apical–basal axis of Arabidopsis
Friml, J., Vieten, A., Sauer, M., Weijers, D., Schwarz, H., Hamann, T., Offringa, R., & Jürgens, G. (2003) · Nature · doi:10.1038/nature02085 · Cited by 1,896
Self-citationThe Arabidopsis F-box protein TIR1 is an auxin receptor
Kepinski, S., & Leyser, O. (2005) · Nature · doi:10.1038/nature03542 · Cited by 1,703
Regulation of phyllotaxis by polar auxin transport
Reinhardt, D., Pesce, E.-R., Stieger, P., Mandel, T., Baltensperger, K., Bennett, M., Traas, J., Friml, J., & Kuhlemeier, C. (2003) · Nature · doi:10.1038/nature02081 · Cited by 1,523
Self-citationSteeves, T. A., & Sussex, I. M. (1989) · doi:10.1017/cbo9780511626227 · Cited by 1,334
Auxin transport inhibitors block PIN1 cycling and vesicle trafficking
Geldner, N., Friml, J., Stierhof, Y.-D., Jürgens, G., & Palme, K. J. (2001) · Nature · doi:10.1038/35096571 · Cited by 1,244
Self-citationHeisler, M. G., Ohno, C., Das, P., Sieber, P., Reddy, G. V., Long, J. A., & Meyerowitz, E. M. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.052 · Cited by 1,189
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Sorted by citations
Auxin: A Trigger for Change in Plant Development
Vanneste, S., & Friml, J. (2009) · Cell · doi:10.1016/j.cell.2009.03.001 · Cited by 1,347
Self-citationSignal integration in the control of shoot branching
Domagalska, M. A., & Leyser, O. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3088 · Cited by 835
Auxin transport routes in plant development
Petrášek, J., & Friml, J. (2009) · Development · doi:10.1242/dev.030353 · Cited by 845
Self-citationPIN-Dependent Auxin Transport: Action, Regulation, and Evolution
Adamowski, M., & Friml, J. (2015) · The Plant Cell · doi:10.1105/tpc.114.134874 · Cited by 833
Self-citationLeyser, O. (2018) · Plant Physiology · doi:10.1104/pp.17.00765 · Cited by 715
Metadata
- Authors
- Sauer, M., Balla, J., Luschnig, C., Wiśniewska, J., Reinöhl, V., Friml, J., & Benková, E.
- Affiliations
- University of Tübingen (DE)
- Mendel University in Brno (CZ)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-10-15
- Volume
- 20
- Issue
- 20
- Pages
- 2902-2911
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC1619939
- OpenAlex
- W2105722863
- Cited by
- 453
- References
- 45
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 15 · 2023: 10 · 2022: 20 · 2021: 25 · 2020: 22 · 2019: 19 · 2018: 22 · 2017: 15 · 2016: 26 · 2015: 21 · 2014: 33 · 2013: 37 · 2012: 28
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Volkswagen Foundation
- Grantová Agentura České Republiky
- Fundacja na rzecz Nauki Polskiej
- Austrian Science Fund
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
- Keywords
- auxin transport, PIN auxin efflux carriers, canalization, auxin response factor, auxin response, cell polarity, tissue polarity, wounding, organ formation, plant regeneration, feedback regulation
- MeSH terms
- Indoleacetic Acids, Plant Growth Regulators, Plant Proteins, Transcription, Genetic, Signal Transduction, Arabidopsis, Gene Expression Regulation, Plant, Plant Roots, Plant Physiological Phenomena, Phototropism, Pisum sativum, Arabidopsis Proteins
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