The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
bag-of-marbles: a Drosophila gene required to initiate both male and female gametogenesis.
Open accessAbstract
In Drosophila, male and female gametes begin development when a stem cell divides to produce a cyst precursor. Subsequently, four special divisions give rise to a cluster of 16 interconnected cystocytes that develop into a single egg or 64 sperm. We identified and characterized a gene, bag-of-marbles (bam), that disrupts cyst formation in both sexes. An apparent null mutation causes abnormal cysts to form containing an excess number of cells that cannot differentiate into gametes. bam function resides within a simple 2.2-kb transcription unit encoding a single 442-amino-acid protein that shows similarity to the product of the ovarian tumor gene. The specific expression of bam RNA within female cystoblasts suggested that it might be involved in the specific cell-cycle alterations that occur during cystocyte divisions.
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Cited by
Xie, T., & Spradling, A. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81424-5 · Cited by 668
Self-citationChanges in rRNA transcription influence proliferation and cell fate within a stem cell lineage
Zhang, Q., Shalaby, N. A., & Buszczak, M. (2014) · Science · doi:10.1126/science.1246384 · Cited by 192
Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss.
Amartuvshin, O., Lin, C., Hsu, S., Kao, S., Chen, A., Tang, W., Chou, H., Chang, D., Hsu, Y., Hsiao, B., et al. (2020) · Aging Cell · doi:10.1111/acel.13191 · Cited by 75
Blocking promiscuous activation at cryptic promoters directs cell type–specific gene expression
Kim, J., Lu, C., Srinivasan, S., Awe, S., Brehm, A., & Fuller, M. T. (2017) · Science · doi:10.1126/science.aal3096 · Cited by 39
Gui, J., Samuels, T. J., Grobicki, K. Z. A., & Teixeira, F. K. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112181 · Cited by 19
Metadata
- Authors
- McKearin, D. M., & Spradling, A. C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1990-12-01
- Volume
- 4
- Issue
- 12b
- Pages
- 2242-2251
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2165780130
- Cited by
- 399
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- McKearin, D. M., & Spradling, A. C. (1990). bag-of-marbles: a Drosophila gene required to initiate both male and female gametogenesis. Genes & Development. https://doi.org/10.1101/gad.4.12b.2242
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