Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila.

González-Crespo, S; Levine, M

doi:10.1101/gad.7.9.1703

Cited by 79Developmental Biology and Gene RegulationGenomics and Chromatin DynamicsWnt/β-catenin signaling in development and cancer

Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila.

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González-Crespo, S, Levine, M·1993·Genes & Development

DOI 10.1101/gad.7.9.1703

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Abstract

The dorsal (dl) morphogen has been implicated in the establishment of the embryonic mesoderm, neuroectoderm, and dorsal ectoderm in Drosophila. Here we show that the simultaneous reduction in the levels of dl and any one of several helix-loop-helix (HLH) proteins results in severe disruptions in the formation of mesoderm and neuroectoderm. Certain triple heterozygous combinations essentially lack mesoderm as a result of a block in ventral furrow formation during gastrulation. HLH proteins that have been implicated previously in sex determination and neurogenesis (daughterless, achaete, and scute) are shown to be required for the formation of these embryonic tissues. Evidence is also presented that dl-HLH interactions involve the direct physical association of these proteins in solution mediated by the rel and HLH domains. We discuss the striking parallels in mesoderm formation and sex determination.

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Synergistic DNA binding between Dorsal and Twist, a bHLH transcription factor, permits gene expression in more lateral regions of the embryo where neither Dorsal nor Twist is capable of inducing gene expression independently.
“synergistic DNA binding between Dorsal and Twist, a bHLH transcription factor, permits gene expression in more lateral regions of the embryo where neither Dorsal nor Twist is capable of inducing gene expression independently”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Gonzalez-Crespo and Levine 1993
In “The role of dl-HLH interactions in development” (page unavailable), the paper says Dorsal–Twist interactions have been proposed to let intermediate Dorsal levels in ventrolateral regions activate snail expression; it also describes their effects as multiplicative. In “Mechanism of dl-HLH interactions” (page unavailable), cooperative promoter activation by Dorsal–Twist complexes is presented as a possibility, not an established finding of synergistic DNA binding. The copy does not establish that neither protein could induce expression independently in those regions. (LLM, conf=0.85)
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Authors: González-Crespo, S., & Levine, M.
Affiliations: University of California San Diego (US)
ORCID: Levine, M
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1993-09
Volume: 7
Issue: 9
Pages: 1703-1713
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.7.9.1703
OpenAlex: W2008076522
Cited by: 79
References: 41
Citations by year: 2022: 1 · 2021: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (GM 46638)
National Institute of General Medical Sciences (GM-46638)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Keywords: helix-loop-helix proteins, embryonic mesoderm, neuroectoderm, dorsal ectoderm, Drosophila embryogenesis, gastrulation, ventral furrow formation, Daughterless, achaete, scutes, sex determination, protein-protein interaction
MeSH terms: Animals, Base Sequence, Cell Differentiation, DNA-Binding Proteins, Drosophila, Ectoderm, Biological Evolution, Female, Heterozygote, Male, Mesoderm, Molecular Sequence Data, Nervous System, Nuclear Proteins, Oligodeoxyribonucleotides, Phosphoproteins, Transcription Factors, Gene Expression, Drosophila Proteins

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Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila.

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