The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.
Open accessAbstract
Translation of encephalomyocarditis virus (EMCV) mRNA occurs by ribosomal internal entry into the 5'-nontranslated region (5' NTR) rather than by ribosomal scanning. The internal ribosomal entry site (IRES) in the EMCV 5' NTR was determined by in vitro translation with RNAs that were generated by in vitro transcription of EMCV cDNAs containing serial deletions from either the 5' or 3' end of the EMCV 5' NTR. Regions downstream of nucleotide 403 and upstream of nucleotide 811 of EMCV were required for efficient translation. Site-directed mutagenesis revealed that a stem-loop structure (400 nucleotides upstream of the initiation codon) was essential for IRES function. We discovered a 57-kD cellular protein whose specific interaction with this stem-loop appears to be prerequisite for IRES function. A A pyrimidine-rich stretch proximal to the initiation codon was also crucial for efficient translation of EMCV mRNA. We propose that ribosomes bind directly to the initiating AUG without scanning.
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Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Pelletier, J., & Sonenberg, N. (1988) · Nature · doi:10.1038/334320a0 · Cited by 1,934
Rapid Evolution of RNA Genomes
Holland, J., Spindler, K., Horodyski, F., Grabau, E., Nichol, S., & VandePol, S. (1982) · Science · doi:10.1126/science.7041255 · Cited by 1,477
Jang, S. K., Kräusslich, H. G., Nicklin, M. J., Duke, G. M., Palmenberg, A. C., & Wimmer, E. (1988) · Journal of Virology · doi:10.1128/jvi.62.8.2636-2643.1988 · Cited by 1,362
Self-citationHow do eucaryotic ribosomes select initiation regions in messenger RNA?
Kozak, M. (1978) · Cell · doi:10.1016/0092-8674(78)90039-9 · Cited by 815
Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs
Konarska, M. M., & Sharp, P. A. (1986) · Cell · doi:10.1016/0092-8674(86)90066-8 · Cited by 461
Jang, S. K., Davies, M. V., Kaufman, R. J., & Wimmer, E. (1989) · Journal of Virology · doi:10.1128/jvi.63.4.1651-1660.1989 · Cited by 413
Self-citationSchreier, M. H., & Staehelin, T. (1973) · Journal of Molecular Biology · doi:10.1016/0022-2836(73)90346-x · Cited by 387
Synthesis of infectious poliovirus RNA by purified T7 RNA polymerase.
van der Werf, S., Bradley, J., Wimmer, E., Studier, F. W., & Dunn, J. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2330 · Cited by 337
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Mammalian genes are transcribed with widely different bursting kinetics
Suter, D. M., Molina, N., Gatfield, D., Schneider, K., Schibler, U., & Naef, F. (2011) · Science · doi:10.1126/science.1198817 · Cited by 927
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Zwaka, T. P., & Thomson, J. A. (2003) · Nature Biotechnology · doi:10.1038/nbt788 · Cited by 666
Wimmer, E., Hellen, C. U. T., & Cao, X. (1993) · Annual Review of Genetics · doi:10.1146/annurev.ge.27.120193.002033 · Cited by 554
Self-citationLa autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate
Meerovitch, K., Svitkin, Y. V., Lee, H. S., Lejbkowicz, F., Kenan, D. J., Chan, E. K., Agol, V. I., Keene, J. D., & Sonenberg, N. (1993) · Journal of Virology · doi:10.1128/jvi.67.7.3798-3807.1993 · Cited by 493
Liu, Y., Kim, D., Himes, B. T., Chow, S. Y., Schallert, T., Murray, M., Tessler, A., & Fischer, I. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04370.1999 · Cited by 477
Metadata
- Authors
- Jang, S. K., & Wimmer, E.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1990-09
- Volume
- 4
- Issue
- 9
- Pages
- 1560-1572
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2103410475
- Cited by
- 414
- References
- 41
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein. https://app.cochat.ai/papers/10.1101/gad.4.9.1560
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- Jang, S. K., & Wimmer, E. (1990). Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein. Genes & Development. https://doi.org/10.1101/gad.4.9.1560
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