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Cited by 570

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Maternal microRNAs are essential for mouse zygotic development

Open access
Tang, Fuchou, Kaneda, Masahiro, O’Carroll, Dónal, Hajkova, Petra, Barton, Sheila C., Sun, Y. Andrew, Lee, Caroline, Tarakhovsky, Alexander, Lao, Kaiqin, Surani, M. Azim·2007·Genes & Development

Abstract

MicroRNAs (miRNAs) have important roles in diverse cellular processes, but little is known about their identity and functions during early mammalian development. Here, we show the effects of the loss of maternal inheritance of miRNAs following specific deletion of Dicer from growing oocytes. The mutant mature oocytes were almost entirely depleted of all miRNAs, and they failed to progress through the first cell division, probably because of disorganized spindle formation. By comparing single-cell cDNA microarray profiles of control and mutant oocytes, our data are compatible with the notion that a large proportion of the maternal genes are directly or indirectly under the control of miRNAs, which demonstrates that the maternal miRNAs are essential for the earliest stages of mouse embryonic development.

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Metadata

Authors
Tang, F., Kaneda, M., O’Carroll, D., Hajkova, P., Barton, S. C., Sun, Y. A., Lee, C., Tarakhovsky, A., Lao, K., & Surani, M. A.
Venue
Genes & Development
Published
2007-03-15
Volume
21
Issue
6
Pages
644-648
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2112703265
Cited by
570
References
6
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: Maternal microRNAs are essential for mouse zygotic development. https://app.cochat.ai/papers/10.1101/gad.418707
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Tang, F., Kaneda, M., O’Carroll, D., Hajkova, P., Barton, S. C., Sun, Y. A., Lee, C., Tarakhovsky, A., Lao, K., & Surani, M. A. (2007). Maternal microRNAs are essential for mouse zygotic development. Genes & Development. https://doi.org/10.1101/gad.418707

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