The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Senescent cells develop a parp-1 and nuclear factor-κB-associated secretome (PNAS).
Open accessAbstract
Melanoma cells can enter the process of senescence, but whether they express a secretory phenotype, as reported for other cells, is undetermined. This is of paramount importance, because this secretome can alter the tumor microenvironment and the response to chemotherapeutic drugs. More generally, the molecular events involved in formation of the senescent-associated secretome have yet to be determined. We reveal here that melanoma cells experiencing senescence in response to diverse stimuli, including anti-melanoma drugs, produce an inflammatory secretory profile, where the chemokine ligand-2 (CCL2) acts as a critical effector. Thus, we reveal how senescence induction might be involved in therapeutic failure in melanoma. We further provide a molecular relationship between senescence induction and secretome formation by revealing that the poly(ADP-ribose) polymerase-1 (PARP-1)/nuclear factor-κB (NF-κB) signaling cascade, activated during senescence, drives the formation of a secretome endowed with protumoral and prometastatic properties. Our findings also point to the existence of the PARP-1 and NF-κB-associated secretome, termed the PNAS, in nonmelanoma cells. Most importantly, inhibition of PARP-1 or NF-κB prevents the proinvasive properties of the secretome. Collectively, identification of the PARP-1/NF-κB axis in secretome formation opens new avenues for therapeutic intervention against cancers.
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In the citing paper
“Chemotherapeutic drugs or oxidative stress induced DNA damage engage PARP-1/ATM/NF-κB signaling cascade to induce senescence in melanoma and non-melanoma cells (Ohanna et al., 2011).”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Ohanna et al., 2011
Experimental — accuracy not yet measuredIn the citing paper
“Blocking PARP-1, ATM, or NF-κB in melanoma cells prevents the secretion of chemokine CCL2 thereby restricting the deleterious pro-invasive properties of the inflammatory SASP mediated by PNAS (Ohanna et al., 2011).”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Ohanna et al., 2011
In the citing paper
“These senescent cells develop a PARP-1 and NF-κB associated secretome (PNAS) containing chemokine CCL2 along with other SASP factors thereby augmenting the invasiveness of melanoma cells which might have escaped senescence.”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Ohanna et al., 2011
In the citing paper
“some tumor cells can enter senescence in response to DNA damaging therapies [363,364].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [364]
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Citations
Cites
1 retracted
Ionizing radiation-induced NF-κB activation requires PARP-1 function to confer radioresistance
Veuger, S. J., Hunter, J. E., & Durkacz, B. W. (2008) · Oncogene · doi:10.1038/onc.2008.439 · Cited by 134
RetractedOncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 1×
“Ordinarily, senescence is a process arising in normal cells in response to telomere erosion or oncogenic stress, acting through checkpoint activation and cell cycle arrest as a barrier to tumorigenesis (Serrano et al. 1997; Steinert et al. 2000).”
BackgroundThe senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
The Nuclear Factor NF- B Pathway in InflammationPreprint
Lawrence, T. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001651 · Cited by 5,126
Hartwell, L. H., & Kastan, M. B. (1994) · Science · doi:10.1126/science.7997877 · Cited by 2,539
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086
Cell Cycle Checkpoints: Preventing an Identity Crisis
Elledge, S. J. (1996) · Science · doi:10.1126/science.274.5293.1664 · Cited by 2,050
Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801 · cited 1×
“Some of these factors display cell-autonomous activity and work to reinforce the senescence program (Acosta et al. 2008; Kuilman et al. 2008).”
BackgroundKrtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730
DNA repair pathways as targets for cancer therapy
Helleday, T., Petermann, E., Lundin, C., Hodgson, B., & Sharma, R. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2342 · Cited by 1,666
Garraway, L. A., Widlund, H. R., Rubin, M. A., Getz, G., Berger, A. J., Ramaswamy, S., Beroukhim, R., Milner, D. A., Granter, S. R., Du, J., et al. (2005) · Nature · doi:10.1038/nature03664 · Cited by 1,548
Living on a break: cellular senescence as a DNA-damage response
d'Adda di Fagagna, F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2440 · Cited by 1,170
A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
Schmitt, C. A., Fridman, J. S., Yang, M., Lee, S., Baranov, E., Hoffman, R. M., & Lowe, S. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00734-1 · Cited by 1,050
Senescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909
Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M., & Green, M. R. (2008) · Cell · doi:10.1016/j.cell.2007.12.032 · Cited by 903
Apoptosis and melanoma chemoresistance
Soengas, M. S., & Lowe, S. W. (2003) · Oncogene · doi:10.1038/sj.onc.1206454 · Cited by 836
Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α
Imbert, V., Rupec, R. A., Livolsi, A., Pahl, H. L., Traenckner, E. B.-M., Mueller‐Dieckmann, C., Farahifar, D., Rossi, B., Auberger, P., Baeuerle, P. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80153-1 · Cited by 647
Self-citation(2002) · PubMed · Cited by 640
Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
Carreira, S., Goodall, J., Denat, L., Rodriguez, M., Nuciforo, P., Hoek, K. S., Testori, A., Larue, L., & Goding, C. R. (2006) · Genes & Development · doi:10.1101/gad.406406 · Cited by 608
Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli
Wu, Z., Shi, Y., Tibbetts, R. S., & Miyamoto, S. (2006) · Science · doi:10.1126/science.1121513 · Cited by 515
Liu, D., & Hornsby, P. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3452 · Cited by 499
An integrated approach to uncover drivers of cancer
Akavia, U. D., Litvin, O., Kim, J., Sanchez-Garcia, F., Kotliar, D., Causton, H. C., Pochanard, P., Mozes, E., Garraway, L. A., & Pe'er, D. (2010) · Cell · doi:10.1016/j.cell.2010.11.013 · Cited by 484
Bavik, C., Coleman, I., Dean, J. P., Knudsen, B., Plymate, S., & Nelson, P. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1716 · Cited by 453
Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms
Li, N., & Karin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13012 · Cited by 429
Fifteen-year quest for microphthalmia-associated transcription factor target genes
Chéli, Y., Ohanna, M., Ballotti, R., & Bertolotto, C. (2009) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2009.00653.x · Cited by 362
Self-citationBertolotto, C., Buscà, R., Abbe, P., Bille, K., Aberdam, É., Ortonne, J. P., & Ballotti, R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.694 · Cited by 317
Self-citationCoppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · cited 4×
“Quantitative RT–PCR (qRT–PCR) experiments were also performed on a panel of cytokines reported previously in the secretome of human fibroblasts and epithelial cells (Coppe et al. 2008).”
BackgroundMethodInfluentialInterferon-γ links ultraviolet radiation to melanomagenesis in mice
Zaidi, M. R., Davis, S., Noonan, F. P., Graff-Cherry, C., Hawley, T. S., Walker, R. L., Feigenbaum, L., Fuchs, E., Lyakh, L., Young, H. A., et al. (2011) · Nature · doi:10.1038/nature09666 · Cited by 293
Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF
Wellbrock, C., Rana, S., Paterson, H., Pickersgill, H., Brummelkamp, T. R., & Marais, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002734 · Cited by 289
Strub, T., Giuliano, S., Ye, T., Bonet, C., Keime, C., Kobi, D., Le Gras, S., Cormont, M., Ballotti, R., Bertolotto, C., et al. (2011) · Oncogene · doi:10.1038/onc.2010.612 · Cited by 269
Self-citationVance, K. W., Carreira, S., Brosch, G., & Goding, C. R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3045 · Cited by 234
A nuclear poly(ADP-Ribose)-dependent signalosome confers DNA damage-induced IκB kinase activation.
Stilmann, M., Hinz, M., Arslan, S. Ç., Zimmer, A., Schreiber, V., & Scheidereit, C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.032 · Cited by 232
Chéli, Y., Guiliano, S., Botton, T., Rocchi, S., Hofman, V., Hofman, P. M., Bahadoran, P., Bertolotto, C., & Ballotti, R. (2011) · Oncogene · doi:10.1038/onc.2010.598 · Cited by 231
Self-citationZhuang, D., Mannava, S., Grachtchouk, V., Tang, W. H., Patil, S. B., Wawrzyniak, J. A., Berman, A. E., Giordano, T. J., Prochownik, E. V., Soengas, M. S., et al. (2008) · Oncogene · doi:10.1038/onc.2008.258 · Cited by 219
Kolthur‐Seetharam, U., Dantzer, F., McBurney, M. W., de MURCIA, G., & Sassone‐Corsi, P. (2006) · Cell Cycle · doi:10.4161/cc.5.8.2690 · Cited by 209
Oncogenic MITF dysregulation in clear cell sarcoma: Defining the MiT family of human cancers
Davis, I. J., Kim, J. J., Ozsolak, F., Widlund, H. R., Rozenblatt–Rosen, O., Granter, S. R., Du, J., Fletcher, J. A., Denny, C. T., Lessnick, S. L., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.021 · Cited by 206
ATM Is Required for IκB Kinase (IKK) Activation in Response to DNA Double Strand Breaks
Li, N., Banin, S., Ouyang, H., Li, G. C., Courtois, G., Shiloh, Y., Karin, M., & Rotman, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009809200 · Cited by 188
Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy
Zhu, X., Fujita, M., Snyder, L. A., & Okada, H. (2010) · Journal of Neuro-Oncology · doi:10.1007/s11060-010-0473-5 · Cited by 185
The ATM protein is required for sustained activation of NF-κB following DNA damage
Piret, B., Schoonbroodt, S., & Piette, J. (1999) · Oncogene · doi:10.1038/sj.onc.1202541 · Cited by 176
Poly(ADP‐ribose) Polymerase–1 Activation During DNA Damage and Repair
Dantzer, F., Amé, J., Schreiber, V., Nakamura, J., Murcia, J. M., & de MURCIA, G. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)09029-4 · Cited by 167
Yang, J., Amiri, K. I., Burke, J. R., Schmid, J. A., & Richmond, A. J. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1220 · Cited by 167
NF-κB Activation by Camptothecin
Huang, T. T., Wuerzberger‐Davis, S. M., Seufzer, B. J., Shumway, S. D., Kurama, T., Boothman, D. A., & Miyamoto, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9501 · Cited by 158
Tbx3 Represses E-Cadherin Expression and Enhances Melanoma Invasiveness
Rodriguez, M., Aladowicz, E., Lanfrancone, L., & Goding, C. R. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0301 · Cited by 157
Cross talk between stimulated NF-κB and the tumor suppressor p53
Schneider, G., Henrich, A., Greiner, G., Wolf, V, Lovas, A., Wieczorek, M., Wagner, T., Reichardt, S., von Werder, A., Schmid, R. M., et al. (2010) · Oncogene · doi:10.1038/onc.2010.46 · Cited by 149
Tumors induce complex DNA damage in distant proliferative tissues in vivo
Redon, C. E., Dickey, J. S., Nakamura, A., Kareva, I., Näf, D., Nowsheen, S., Kryston, T. B., Bonner, W. M., Georgakilas, A. G., & Sedelnikova, O. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008260107 · Cited by 145
Transient Expression of Human Telomerase Extends the Life Span of Normal Human Fibroblasts
Steinert, S., Shay, J. W., & Wright, W. E. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3080 · Cited by 136
Giuliano, S., Cheli, Y., Ohanna, M., Bonet, C., Beuret, L., Bille, K., Loubat, A., Hofman, V., Hofman, P., Ponzio, G., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2913 · Cited by 135
Self-citationAbdel-Malek, Z. A., Kadekaro, A. L., & Swope, V. B. (2010) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00679.x · Cited by 134
PARP-1 modifies the effectiveness of p53-mediated DNA damage response
Valenzuela, M. T., Guerrero, R., Núñez, M. I., de Almodóvar, J. M. R., Sarker, M., de MURCIA, G., & Oliver, F. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205169 · Cited by 123
Lev, D. C., Ruiz, M., Mills, L., McGary, E. C., Price, J. E., & Bar‐Eli, M. (2003) · PubMed · Cited by 121
An Oncogenic Role for ETV1 in Melanoma
Jané-Valbuena, J., Widlund, H. R., Perner, S., Johnson, L. A., Dibner, A. C., Lin, W. M., Baker, A. C., Nazarian, R. M., Vijayendran, K. G., Sellers, W. R., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3092 · Cited by 115
Overcoming apoptosis deficiency of melanoma—Hope for new therapeutic approaches
Eberle, J., Kurbanov, B. M., Hossini, A. M., Trefzer, U., & Fecker, L. F. (2007) · Drug Resistance Updates · doi:10.1016/j.drup.2007.09.001 · Cited by 112
Wieler, S., Gagné, J., Vaziri, H., Poirier, G. G., & Benchimol, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211641200 · Cited by 110
Hilmi, C., Larribère, L., Giuliano, S., Bille, K., Ortonne, J. P., Ballotti, R., & Bertolotto, C. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701185 · Cited by 104
Self-citationLiu, F., Fu, Y., & Meyskens, F. L. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.255 · Cited by 104
Conditional ablation of Ikkb inhibits melanoma tumor development in mice
Yang, J., Splittgerber, R. C., Yull, F. E., Kantrow, S. M., Ayers, G. D., Karin, M., & Richmond, A. J. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42358 · Cited by 102
A Central Role for Tumor-derived Monocyte Chemoattractant Protein-1 in Malignant Pleural Effusion
Stathopoulos, G. T., Psallidas, I., Moustaki, A., Moschos, C., Kollintza, A., Karabela, S. P., Porfyridis, I., Vassiliou, S., Karatza, M., Zhou, Z., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn325 · Cited by 100
Khaled, M., Larribère, L., Bille, K., Ortonne, J. P., Ballotti, R., & Bertolotto, C. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12420.x · Cited by 92
Self-citationTemozolomide induces senescence but not apoptosis in human melanoma cells
Mhaidat, N. M., Zhang, X. D., Allen, J., Avery‐Kiejda, K. A., Scott, R. J., & Hersey, P. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6604017 · Cited by 92
Pinlaor, S. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i30.4644 · Cited by 82
Matsubara, D., Niki, T., Ishikawa, S., Goto, A., Ohara, E., Yokomizo, T., Heizmann, C. W., Aburatani, H., Moriyama, S., Moriyama, H., et al. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00121.x · Cited by 71
Larribère, L., Hilmi, C., Khaled, M., Gaggioli, C., Bille, K., Auberger, P., Ortonne, J. P., Ballotti, R., & Bertolotto, C. (2005) · Genes & Development · doi:10.1101/gad.335905 · Cited by 67
Self-citationCzesnikiewicz-Guzik, M., Bielański, W., Guzik, T. J., Loster, B. W., & Konturek, S. J. (2005) · PubMed · Cited by 60
Systemic Targeting Inhibitor of κB Kinase Inhibits Melanoma Tumor Growth
Yang, J., Pan, W.-H., Clawson, G. A., & Richmond, A. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3547 · Cited by 52
Advances in melanoma senescence and potential clinical application
Giuliano, S., Ohanna, M., Ballotti, R., & Bertolotto, C. (2010) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00820.x · Cited by 39
Self-citationWęsierska‐Gądek, J., Ranftler, C., & Schmid, G. (2005) · PubMed · Cited by 27
Tentori, L., Muzi, A., Dorio, A. S., Scarsella, M., Leonetti, C., Shah, G. M., Xu, W., Camaioni, E., Gold, B. I., Pellicciari, R., et al. (2010) · Current Cancer Drug Targets · doi:10.2174/156800910791208571 · Cited by 18
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Metadata
- Authors
- Ohanna, M., Giuliano, S., Bonet, C., Imbert, V., Hofman, V., Zangari, J., Bille, K., Robert, C., Bressac-de Paillerets, B., Hofman, P., Rocchi, S., Peyron, J.-F., Lacour, J.-P., Ballotti, R., & Bertolotto, C.
- Affiliations
- Inserm (FR)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire de Nice (FR)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-06-06
- Volume
- 25
- Issue
- 12
- Pages
- 1245-1261
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC3127427
- OpenAlex
- W2162942873
- Cited by
- 267
- References
- 67
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 17 · 2023: 24 · 2022: 20 · 2021: 33 · 2020: 25 · 2019: 15 · 2018: 16 · 2017: 13 · 2016: 16 · 2015: 17 · 2014: 13 · 2013: 21 · 2012: 15
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- Institut National de la Santé et de la Recherche Médicale
- Fondation de France
- Institut National Du Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- cellular senescence, senescence-associated secretome, melanoma, PARP1, NF-κB signaling, MCP-1, chemokines, tumor microenvironment, chemoresistance, metastasis, tumor invasion
- MeSH terms
- Poly (ADP-Ribose) Polymerase-1, DNA Damage, Humans, Melanoma, Neoplasm Invasiveness, Poly(ADP-ribose) Polymerases, Signal Transduction, Gene Expression Regulation, Neoplastic, NF-kappa B, Cellular Senescence, Chemokine CCL2, Gene Expression Profiling, Cell Line, Tumor
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