Stepping up melanocytes to the challenge of UV exposure
Abstract
Exposure to solar ultraviolet radiation (UV) is the main etiological factor for skin cancer, including melanoma. Cutaneous pigmentation, particularly eumelanin, afforded by melanocytes is the main photoprotective mechanism, as it prevents UV-induced DNA damage in the epidermis. Therefore, maintaining genomic stability of melanocytes is crucial for prevention of melanoma, as well as keratinocyte-derived basal and squamous cell carcinoma. A critical independent factor for preventing melanoma is DNA repair capacity. The response of melanocytes to UV is mediated mainly by a network of paracrine factors that not only activate melanogenesis, but also DNA repair, anti-oxidant, and survival pathways that are pivotal for maintenance of genomic stability and prevention of malignant transformation or apoptosis. However, little is known about the stress response of melanocytes to UV and the regulation of DNA repair pathways in melanocytes. Unraveling these mechanisms might lead to strategies to prevent melanoma, as well as non-melanoma skin cancer.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A therapeutic dosage of UV can induce cell cycle arrest, activate antioxidant and DNA repair enzymes, and induce apoptosis through translocation of Bcl-2 family proteins in melanocytes to ensure genomic integrity and survival of melanocytes.
“Analogous to its effect in keratinocytes, a therapeutic dosage of UV can induce cell cycle arrest, activate antioxidant and DNA repair enzymes, and induce apoptosis through translocation of the Bcl-2 family proteins in melanocytes to ensure genomic integrity and survival of melanocytes.”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [76]
Similar to keratinocytes, UV induces cell cycle arrest, activation of antioxidant and DNA repair enzymes, and regulation of apoptotic pathways in melanocytes, to ensure genomic integrity and survival of melanocytes.
“Similar to that seen in keratinocytes, UV induces cell cycle arrest, activation of antioxidant and DNA repair enzymes, and regulation of apoptotic pathways in melanocytes, to ensure genomic integrity and survival of melanocytes [76].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [76]
Exposure of the skin to UV results in increased synthesis of paracrine factors such as ACTH, endothelin-1, β-FGF, and α-MSH, which mediate the UV response of human melanocytes.
“Several studies have reported that exposure of the skin to UV results in increased synthesis of paracrine factors, such as ACTH, endothelin-1, β-FGF, and α-MSH, which play an important role in mediating the UV response of human melanocytes [76].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [76]
UV can induce the activation of transcription factors USF-1, Mitf, ATF-2, Nrf-2 and p53, and inhibition of NFκB.
“In addition to the induction of paracrine factors, UV can induce the activation of the transcription factors USF-1, Mitf, ATF-2, Nrf-2 and p53, and inhibition of NFκB [76].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [76]
Cites
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634 · see citing works
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317 · see citing works
A comprehensive catalogue of somatic mutations from a human cancer genome
Pleasance, E. D., Cheetham, R. K., Stephens, P. J., McBride, D. J., Humphray, S. J., Greenman, C. D., Varela, I., Lin, M.-L., Ordóñez, G. R., Bignell, G. R., et al. (2010) · Nature · doi:10.1038/nature08658 · Cited by 1,696 · see citing works
SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
Lamason, R. L., Mohideen, M.-A. P. K., Mest, J. R., Wong, A. C., Norton, H. L., Aros, M. C., Jurynec, M. J., Mao, X., Humphreville, V. R., Humbert, J. E., et al. (2005) · Science · doi:10.1126/science.1116238 · Cited by 1,043 · see citing works
The pathogenesis of melanoma induced by ultraviolet radiation
Gilchrest, B. A., Eller, M. S., Geller, A. C., & Yaar, M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904293401707 · Cited by 876 · see citing works
Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
Chen, W., Sun, Z., Wang, X.-J., Jiang, T., Huang, Z., Fang, D., & Zhang, D. D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.029 · Cited by 638 · see citing works
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
Krimpenfort, P., Quon, K. C., Mooi, W. J., Loonstra, A., & Berns, A. (2001) · Nature · doi:10.1038/35092584 · Cited by 568 · see citing works
Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes
Imokawa, G., Yada, Y., & Miyagishi, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35817-4 · Cited by 385 · see citing works
UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin
Tadokoro, T., Kobayashi, N., Zmudzka, B. Z., Ito, S., Wakamatsu, K., Yamaguchi, Y., Korossy, K. S., Miller, S. A., Beer, J. Z., & Hearing, V. J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0865fje · Cited by 378 · see citing works
Ultraviolet B but not Ultraviolet A Radiation Initiates Melanoma
De Fabo, E. C., Noonan, F. P., Fears, T., & Merlino, G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1454 · Cited by 279 · see citing works
Supranuclear melanin caps reduce ultraviolet induced DNA photoproducts in human epidermis
Kobayashi, N., Nakagawa, A., Muramatsu, T., Yamashina, Y., Shirai, T., Hashimoto, M. W., Ishigaki, Y., Ohnishi, T., & Mori, T. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00178.x · Cited by 257 · see citing works
Böhm, M., Wolff, I., Scholzen, T. E., Robinson, S. J., Healy, E., Luger, T. A., Schwarz, T., & Schwarz, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m406334200 · Cited by 228 · see citing works
Zhang, X., Rosenstein, B. S., Wang, Y., Lebwohl, M., & Wei, H. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00126-3 · Cited by 216 · cited 1× · see citing works
“It is also induced by UVB, and seems to play an important role in the malignant transformation of melanocytes to melanoma, since mutations arising from DNA photoproducts are rare in melanoma tumors (Lubbe et al., 1994; Volkenandt et al., 1991; Zhang et al., 1997), and polymorphisms in NER genes do not seem to have a s…”
BackgroundMarrot, L., Jones, C., Perez, P., & Meunier, J. (2008) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2007.00424.x · Cited by 164 · see citing works
Eumelanin and pheomelanin concentrations in human epidermis before and after UVB irradiation
Hennessy, A., Oh, C., Diffey, B., Wakamatsu, K., Ito, S., & Rees, J. (2005) · Pigment Cell Research · doi:10.1111/j.1600-0749.2005.00233.x · Cited by 132 · see citing works
Kokot, A., Metze, D., Mouchet, N., Galibert, M.-D., Schiller, M., Luger, T. A., & Böhm, M. (2009) · Endocrinology · doi:10.1210/en.2008-1315 · Cited by 132 · see citing works
Sarkar-Agrawal, P., Vergilis, I., Sharpless, N. E., DePinho, R. A., & Runger, T. M. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh307 · Cited by 48 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer
Pfeifer, G. P., & Besaratinia, A. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05144j · Cited by 473 · see citing works
How UV Light Touches the Brain and Endocrine System Through Skin, and Why
Slominski, A. T., Zmijewski, M. A., Plonka, P. M., Szaflarski, J. P., & Paus, R. (2018) · Endocrinology · doi:10.1210/en.2017-03230 · Cited by 452 · see citing works
Key role of CRF in the skin stress response system
Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400 · see citing works
Lee, C.-H., Wu, S.-B., Hong, C.-H., Yu, H.-S., & Wei, Y.-H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036414 · Cited by 271 · see citing works
Senescent cells develop a parp-1 and nuclear factor-κB-associated secretome (PNAS).
Ohanna, M., Giuliano, S., Bonet, C., Imbert, V., Hofman, V., Zangari, J., Bille, K., Robert, C., Bressac-de Paillerets, B., Hofman, P., et al. (2011) · Genes & Development · doi:10.1101/gad.625811 · Cited by 267 · see citing works
Miyamura, Y., Coelho, S. G., Schlenz, K., Batzer, J., Smuda, C., Choi, W., Brenner, M., Passeron, T., Zhang, G., Kolbe, L., et al. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00764.x · Cited by 140 · see citing works
Scott, T. L., Christian, P. A., Kesler, M. V., Donohue, K. M., Shelton, B., Wakamatsu, K., Ito, S., & D'Orazio, J. (2012) · Experimental Dermatology · doi:10.1111/exd.12012 · Cited by 61 · see citing works
Melanocortin MC1 receptor in human genetics and model systems
Beaumont, K. A., Wong, S. S., Ainger, S. A., Liu, Y. Y., Patel, M. P., Millhauser, G. L., Smith, J. J., Alewood, P. F., Leonard, J. H., & Sturm, R. A. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.11.040 · Cited by 47 · see citing works
Melanoma Chemoprevention: Current Status and Future Prospects
Chhabra, G., Ndiaye, M. A., Garcia‐Peterson, L. M., & Ahmad, N. (2017) · Photochemistry and Photobiology · doi:10.1111/php.12749 · Cited by 51 · see citing works
Loss of ARF Sensitizes Transgenic BRAFV600E Mice to UV-Induced Melanoma via Suppression of XPC
Luo, C., Sheng, J., Hu, M. G., Haluska, F. G., Cui, R., Xu, Z., Tsichlis, P. N., Hu, G.-F., & Hinds, P. W. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4454 · Cited by 31 · see citing works
López, S., Alonso, S., García de Galdeano, A., & Smith‐Zubiaga, I. (2015) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/phpp.12169 · Cited by 21 · see citing works
Wäster, P., Rosdahl, I., & Öllinger, K. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13278 · Cited by 15 · see citing works
- Authors
- Abdel-Malek, Z. A., Kadekaro, A. L., & Swope, V. B.
- Affiliations
- University of Cincinnati (US)
- Venue
- Pigment Cell & Melanoma Research
- Publisher
- Wiley
- Published
- 2010-02-01
- Volume
- 23
- Issue
- 2
- Pages
- 171-186
- ISSN
- 1755-1471 (ISSN-L)
- OpenAlex
- W1562209821
- Cited by
- 134
- References
- 17
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 10 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 9 · 2018: 11 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 7 · 2013: 9 · 2012: 15
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pigment Cell & Melanoma Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA114095)
- National Institute of Environmental Health Sciences (P30ES006096, R01ES017561, R01ES009110)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- melanocytes, ultraviolet radiation, melanoma, DNA repair, genome stability, eumelanin, skin pigmentation, melanogenesis, paracrine signaling, non-melanoma skin cancer, UV-induced DNA damage, photoprotection, malignant transformation, apoptosis
- MeSH terms
- Animals, DNA Damage, DNA Repair, Humans, Melanocytes, Melanoma, Skin Neoplasms, Ultraviolet Rays, Genomic Instability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
