The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival.
Open accessAbstract
Oct-2, a POU homeo domain transcription factor, is believed to stimulate B-cell-restricted expression of immunoglobulin genes through binding sites in immunoglobulin gene promoters and enhancers. To determine whether Oct-2 is required for B-cell development or function, or has other developmental roles, the gene was disrupted by homologous recombination. Oct-2-l- mice develop normally but die within hours of birth for undetermined reasons. Mutants contain normal numbers of B-cell precursors but are somewhat deficient in IgM+ B cells. These B cells have a marked defect in their capacity to secrete immunoglobulin upon mitogenic stimulation in vitro. Thus, Oct-2 is not required for the generation of immunoglobulin-bearing B cells but is crucial for their maturation to immunoglobulin-secreting cells and for another undetermined organismal function.
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Cites
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Metadata
- Authors
- Corcoran, L. M., Karvelas, M., Nossal, G. J., Ye, Z. S., Jacks, T., & Baltimore, D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1993-04
- Volume
- 7
- Issue
- 4
- Pages
- 570-582
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2162741904
- Cited by
- 266
- References
- 68
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. https://app.cochat.ai/papers/10.1101/gad.7.4.570
- The paper
- Corcoran, L. M., Karvelas, M., Nossal, G. J., Ye, Z. S., Jacks, T., & Baltimore, D. (1993). Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes & Development. https://doi.org/10.1101/gad.7.4.570
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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