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Cited by 670

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

URBANEK, P·1994·Cell
DOI 10.1016/0092-8674(94)90079-5
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Abstract

The Pax5 gene, coding for the transcription factor BSAP, was mutated in the mouse germline by targeted disruption. Homozygous mutant mice were born alive, became growth retarded, and usually died within three weeks. About 5% of mutants survived to adulthood and were fertile, but severely runted. Morphogenesis of the posterior midbrain was affected as early as embryonic day 16.5, leading to a reduction of the inferior colliculus near the midline and to altered foliation of the anterior cerebellum. Moreover, all mutants failed to produce small pre-B, B, and plasma cells owing to a complete arrest of B cell development at an early precursor stage. These data define a key role for Pax5 in early B lymphopoiesis and midbrain patterning.

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Crossref · 10.1016/0092-8674(94)90079-5

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1 of 1 references verified0 citation errors · 0 not checkable

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  • Developmental progression of B cells is critically dependent on activity of various transcription factors binding to promoter and enhancer elements of Ig genes.

    “In fact, gene-targeting studies indicate that the developmental progression of B cells is critically dependent on the activity of various transcription factors, which bind to promoter and enhancer elements of Ig genes (heavy and light chains), suggesting a link between the signal transduction and transcription factors during B-cell development (13-18”

    From AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain (2001) · cites this paper as [17]

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Metadata

Authors
URBANEK, P.
Venue
Cell
Publisher
Elsevier BV
Published
1994-12
Volume
79
Issue
5
Pages
901-912
ISSN
0092-8674
DOI
10.1016/0092-8674(94)90079-5
Cited by
670
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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