Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

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Items 201–300 of 404

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2. Direct evidence from siRNA-directed “knock down” that p16INK4a is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation
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4. Human myotubes from myoblast cultures undergoing senescence exhibit defects in glucose and lipid metabolism
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5. The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
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6. Hallmarks for senescence in carcinogenesis: novel signaling players
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7. Identification of telomere-dependent "senescence-like" arrest in mouse embryonic fibroblasts.
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8. The ZEB1 Transcription Factor Acts in a Negative Feedback Loop with miR200 Downstream of Ras and Rb1 to Regulate Bmi1 Expression
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9. Telomerase as a Growth-Promoting Factor
   Vera A. Gorbunova, Andrei Seluanov · 2003 · Cell Cycle
10. Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells
    M. Kang, A. Kameta, K. Shin, Marcel A. Baluda, N. Park · 2004 · Journal of Cellular Physiology
11. Identification of cultivation-independent markers of human endothelial cell senescence in vitro
    H. Unterluggauer, Eveline Hütter, R. Voglauer, J. Grillari, M. Vöth, J. Bereiter-Hahn, P. Jansen-Dürr, M. Jendrach · 2007 · Biogerontology (Dordrecht)
12. Role of INK4a/Arf locus-encoded senescent checkpoints activated in normal and psoriatic keratinocytes.
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13. Contributions of Myc to tumorigenesis
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14. Proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, TERT, or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA component, TERC
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15. Telomerase: cellular immortalization and neoplastic transformation. Multiple functions of a multifaceted complex
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16. Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus
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17. Inactivation of Imprinted Genes Induced by Cellular Stress and Tumorigenesis
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18. Telomerase Activation and Rejuvenation of Telomere Length in Stimulated T Cells Derived from Serially Transplanted Hematopoietic Stem Cells
    Richard Allsopp, Samuel Henry Cheshier, Irving L. Weissman · 2002 · The Journal of Experimental Medicine
19. Co-Regulation of p16INK4a and Migratory Genes in Culture Conditions that Lead to Premature Senescence in Human Keratinocytes
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20. CDK2 translational down-regulation during endothelial senescence
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21. Oncogenic transformation of human cells: shortcomings of rodent model systems
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22. Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions
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23. The Emerging Role of Telomerase in Cardiac Muscle Cell Growth and Survival
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24. Telomerase inhibition and the future management of head-and-neck cancer
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25. The Normal Response to RAS: Senescence or Transformation?
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26. An Integrated Human Mammary Epithelial Cell Culture System for Studying Carcinogenesis and Aging
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27. Mechanisms Regulating the Proliferative Potential of Human CD8+ T Lymphocytes Overexpressing Telomerase
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28. Inactivation of p16 , with Retention of pRB and p53/p21 Function, in Human MRC5 Fibroblasts That Overcome a Telomere-independent Crisis during Immortalization
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29. Improved enzymatic isolation of fibroblasts for the creation of autologous skin substitutes
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30. Mesothelial cell: A multifaceted model of aging
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31. p16 Is upregulated in proliferative inflammatory atrophy of the prostate
    Dennis Faith, Steven Han, Daniel K. Lee, Andreas Friedl, Jessica L Hicks, Angelo Michael De Marzo, David Frazier Jarrard · 2005 · The Prostate
32. Degradation of p53, Not Telomerase Activation, by E6 Is Required for Bypass of Crisis and Immortalization by Human Papillomavirus Type 16 E6/E7
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33. Aging of the Skin
    Philip Stephens · 2003 · Springer eBooks
34. Critical and Distinct Roles of p16 and Telomerase in Regulating the Proliferative Life Span of Normal Human Prostate Epithelial Progenitor Cells
    Bobby Bhatia, Ming Jiang, Mahipal V. Suraneni, Lubna Patrawala, Mark D. Badeaux, Robin Schneider‐Broussard, Asha S. Multani, Collene R. Jeter, Tammy Calhoun‐Davis, Limei Hu et al. · 2008 · Journal of Biological Chemistry
35. Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells
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36. Stem cells and aberrant signaling of molecular systems in skin aging
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37. Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells
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38. Polymeric microsphere-facilitated site-specific delivery of quercetin prevents senescence of pancreatic islets in vivo and improves transplantation outcomes in mouse model of diabetes
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39. Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4+ T lymphocytes
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40. New Insights on Molecular Mechanisms of Renal Aging
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41. Characteristic phenotype of immortalized periodontal cells isolated from a Marfan syndrome type I patient
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42. Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies
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43. Methylation of the p16INK4a promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells
    Benjamin W. Darbro, Kristina M. Lee, Nathalie Nguyen, Frederick E. Domann, Aloysius John Klingelhutz · 2006 · Oncogene
44. Effects of Telomerase and Viral Oncogene Expression on the In Vitro Growth of Human Chondrocytes
    James A. Martin, C. J. Mitchell, Aloysius John Klingelhutz, Joseph A. Buckwalter · 2002 · The Journals of Gerontology Series A
45. The flexible evolutionary anchorage-dependent Pardee's restriction point of mammalian cells. How its deregulation may lead to cancer
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46. Malignant Transformation of Non-Neoplastic Barrett's Epithelial Cells through Well-Defined Genetic Manipulations
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47. Vulnerability to oxidative stress and different patterns of senescence in human peritoneal mesothelial cell strains
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48. Mechanisms That Limit the In Vitro Proliferative Potential of Human CD8+ T Lymphocytes
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49. Efficient immortalization of human dental pulp stem cells with expression of cell cycle regulators with the intact chromosomal condition
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50. EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells
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51. On the Regenerative Capacity of Human Skeletal Muscle
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52. Immortalization of Human Mammary Epithelial Cells Is Associated with Inactivation of the p14ARF-p53 Pathway
    Vladimir A. Shamanin, Elliot J. Androphy · 2004 · Molecular and Cellular Biology
53. Total Deletion of in Vivo Telomere Elongation Capacity: An Ambitious but Possibly Ultimate Cure for All Age‐Related Human Cancers
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54. Forward: Aging and cancer: Are telomeres and telomerase the connection?
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55. H-Ras Expression in Immortalized Keratinocytes Produces an Invasive Epithelium in Cultured Skin Equivalents
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56. Repeated exposures to UVB induce differentiation rather than senescence of human keratinocytes lacking p16INK-4A
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57. Telomerase Alone Extends the Replicative Life Span of Human Skeletal Muscle Cells Without Compromising Genomic Stability
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58. Sequential Inductions of the ZEB1 Transcription Factor Caused by Mutation of Rb and Then Ras Proteins Are Required for Tumor Initiation and Progression
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59. Telomere dynamics during replicative senescence are not directly modulated by conditions of oxidative stress in IMR90 fibroblast cells
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60. In non-neoplastic Barrett's epithelial cells, acid exerts early antiproliferative effects through activation of the Chk2 pathway.
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61. Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer
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62. Bacterial aging: from mechanistic basis to evolutionary perspective
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63. Impact on oxidative phosphorylation of immortalization with the telomerase gene
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64. Distinct Mechanisms Control Human Naive and Antigen-Experienced CD8+ T Lymphocyte Proliferation
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65. Immortalization and Transformation of Human Cells
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66. The dual role of cellular senescence in human tumor progression and therapy
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67. Mild hyperoxia limits hTR levels, telomerase activity, and telomere length maintenance in hTERT-transduced bone marrow endothelial cells
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68. Immortalization of ameloblastoma cells via reactivation of telomerase function: Phenotypic and molecular characteristics.
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69. Tissue culture as a hostile environment: identifying conditions for breast cancer progression studies.
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70. Effect of Antioxidants on the Fibroblast Replicative Lifespan In Vitro
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71. Wnt signaling and senescence: A tug of war in early neoplasia?
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72. Induction of the Tumor-Suppressor p16INK4a within Regenerative Epithelial Crypts in Ulcerative Colitis
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74. The molecular signature of in vitro senescence in human mesenchymal stem cells
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75. Telomerase activity is sufficient to bypass replicative senescence in human limbal and conjunctival but not corneal keratinocytes
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76. Translational control of cell fate: From integration of environmental signals to breaching anticancer defense
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77. Isolation and Characterization of Mouse Hepatic Stem Cells in Vitro
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78. Serum from patients with chronic obstructive pulmonary disease induces senescence-related phenotype in bronchial epithelial cells
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79. Molecular docking, antiproliferative and anticonvulsant activities of swertiamarin isolated from Enicostemma axillare.
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80. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM–p53 signaling
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81. Hydrogen peroxide induces p16INK4a through an AUF1‐dependent manner
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82. Complex roles for telomeres and telomerase in breast carcinogenesis
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83. Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson‐Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform
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84. Characterization and Expression of Senescence Marker in Prolonged Passages of Rat Bone Marrow-Derived Mesenchymal Stem Cells
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85. Nevus Senescence
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86. Molecular mechanisms of cellular senescence and immortalization of human cells
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87. Role of TGF-β1-independent changes in protein neosynthesis, p38αMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis
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88. The old second messenger cAMP teams up with novel cell death mechanisms: potential translational therapeutical benefit for Alzheimer’s disease and Parkinson’s disease
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89. The role of senescence in the pathogenesis of atrial fibrillation: A target process for health improvement and drug development
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90. Establishment of human dental epithelial cell lines expressing ameloblastin and enamelin by transfection of hTERT and cdk4 cDNAs.
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91. The role of replicative senescence in cancer and human ageing: utility (or otherwise) of murine models
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93. Endometrial regeneration with endometrial epithelium: homologous orchestration with endometrial stroma as a feeder
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94. Differential Effects of the Extracellular Microenvironment on Human Embryonic Stem Cell Differentiation into Keratinocytes and Their Subsequent Replicative Life Span
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95. The epithelial-mesenchymal transition induced by keratinocyte growth conditions is overcome by E6 and E7 from HPV16, but not HPV8 and HPV38: characterization of global transcription profiles.
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98. Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients
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99. A Two-Stage, p16INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status
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100. SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes
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