ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

Cited by (125)

Items 101–125 of 125

1. Hypophosphorylation of Mdm2 Augments p53 Stability
   Blattner, Christine, Hay, Trevor, Meek, David W., Lane, David P. · 2002 · Molecular and Cellular Biology
2. Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2
   de Graaf, Petra, Little, Natalie A., Ramos, Yolande F.M., Meulmeester, Erik, Letteboer, Stef J.F., Jochemsen, Aart G. · 2003 · Journal of Biological Chemistry
3. MDMX regulation of p53 response to ribosomal stress
   Gilkes, Daniele M, Chen, Lihong, Chen, Jiandong · 2006 · The EMBO Journal
4. Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance
   Kulikov, Roman, Boehme, Karen A., Blattner, Christine · 2005 · Molecular and Cellular Biology
5. DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation
   Okamoto, Koji, Kashima, Kenji, Pereg, Yaron, Ishida, Michiko, Yamazaki, Satomi, Nota, Ayumi, Teunisse, Amina, Migliorini, Domenico, Kitabayashi, Issay, Marine, Jean-Christophe et al. · 2005 · Molecular and Cellular Biology
6. ATM Phosphorylation of Mdm2 Ser394 Regulates the Amplitude and Duration of the DNA Damage Response in Mice
   Gannon, Hugh S., Woda, Bruce A., Jones, Stephen N. · 2012 · Cancer Cell
7. An Alternative Splice Form of Mdm2 Induces p53-independent Cell Growth and Tumorigenesis
   Steinman, Heather A., Burstein, Ezra, Lengner, Christopher, Gosselin, Joseph, Pihan, German, Duckett, Colin S., Jones, Stephen N. · 2004 · Journal of Biological Chemistry
8. c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination
   Vogt Sionov, Ronit, Coen, Sabrina, Goldberg, Zehavit, Berger, Michael, Bercovich, Beatrice, Ben-Neriah, Yinon, Ciechanover, Aaron, Haupt, Ygal · 2001 · Molecular and Cellular Biology
9. Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage
   Pereg, Yaron, Lam, Suzanne, Teunisse, Amina, Biton, Sharon, Meulmeester, Erik, Mittelman, Leonid, Buscemi, Giacomo, Okamoto, Koji, Taya, Yoichi, Shiloh, Yosef et al. · 2006 · Molecular and Cellular Biology
10. Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export
    Shinozaki, Tomomi, Nota, Ayumi, Taya, Yoichi, Okamoto, Koji · 2003 · Oncogene
11. Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases
    Wang, Yunyuan V., Leblanc, Mathias, Wade, Mark, Jochemsen, Aart G., Wahl, Geoffrey M. · 2009 · Cancer Cell
12. A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
    Valentine, Jane M, Kumar, Sonia, Moumen, Abdeladim · 2011 · BMC Cancer
13. The regulation of MDM2 by multisite phosphorylation—opportunities for molecular-based intervention to target tumours?
    Meek, David W., Hupp, Ted R. · 2010 · Seminars in Cancer Biology
14. Phosphorylation and Degradation of MdmX Is Inhibited by Wip1 Phosphatase in the DNA Damage Response
    Zhang, Xinna, Lin, Lin, Guo, Huarong, Yang, Jianhua, Jones, Stephen N., Jochemsen, Aart, Lu, Xiongbin · 2009 · Cancer Research
15. DNA‐damage‐responsive acetylation of pRb regulates binding to E2F‐1
    Markham, Douglas, Munro, Shonagh, Soloway, Judith, O'Connor, Darran P, La Thangue, Nicholas B · 2006 · The EMBO Reports
16. Protein Kinase CK1δ Phosphorylates Key Sites in the Acidic Domain of Murine Double-Minute Clone 2 Protein (MDM2) That Regulate p53 Turnover
    Winter, Markus, Milne, Diane, Dias, Sylvia, Kulikov, Roman, Knippschild, Uwe, Blattner, Christine, Meek, David · 2004 · Biochemistry
17. Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation
    Kulkarni, Amit, Das, Kumuda C. · 2008 · American Journal of Physiology-Lung Cellular and Molecular Physiology
18. Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7.
    Sarkari, Feroz, La Delfa, Anthony, Arrowsmith, Cheryl H., Frappier, Lori, Sheng, Yi, Saridakis, Vivian · 2010 · Journal of Molecular Biology
19. Combination therapy in a xenograft model of glioblastoma: Enhancement of the antitumor activity of temozolomide by an MDM2 antagonist
    Wang, Haiyan, Cai, Shanbao, Bailey, Barbara J., Reza Saadatzadeh, M., Ding, Jixin, Tonsing-Carter, Eva, Georgiadis, Taxiarchis M., Zachary Gunter, T., Long, Eric C., Minto, Robert E. et al. · 2017 · Journal of Neurosurgery
20. Stimulation of human DNA polymerase epsilon by MDM2
    Asahara, H. · 2003 · Nucleic Acids Research
21. The roles of MDM2 and MDMX phosphorylation in stress signaling to p53
    Chen, J. · 2012 · Genes & Cancer
22. Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.
    Tang, Jun, Agrawal, Trisha, Cheng, Qian, Qu, Like, Brewer, Michael D., Chen, Jiandong, Yang, Xiaolu · 2013 · PLoS ONE
23. The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation
    Cheng, Qian, Chen, Jiandong · 2011 · Cell Cycle
24. Protecting the genome from mdm2 and mdmx
    Melo, A. N., Eischen, C. M. · 2012 · Genes & Cancer
25. What do we need to know and understand about p53 to improve its clinical value?
    Salomao, Norman, Karakostis, Konstantinos, Hupp, Ted, Vollrath, Friz, Vojtesek, Borivoj, Fahraeus, Robin · 2021 · The Journal of Pathology