MDMX regulation of p53 response to ribosomal stress

Gilkes, Daniele M; Chen, Lihong; Chen, Jiandong

doi:10.1038/sj.emboj.7601424

Cited by 142Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancerCell death mechanisms and regulation

MDMX regulation of p53 response to ribosomal stress

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Gilkes, Daniele M, Chen, Lihong, Chen, Jiandong·2006·The EMBO Journal

DOI 10.1038/sj.emboj.7601424PMC PMC1679771

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Abstract

Ribosomal stress such as disruption of rRNA biogenesis activates p53 by release of ribosomal proteins from the nucleoli, which bind to MDM2 and inhibit p53 degradation. We found that p53 activation by ribosomal stress requires degradation of MDMX in an MDM2-dependent fashion. Tumor cells overexpressing MDMX are less sensitive to actinomycin D-induced growth arrest due to formation of inactive p53-MDMX complexes. Knockdown of MDMX increases sensitivity to actinomycin D, whereas MDMX overexpression abrogates p53 activation and prevents growth arrest. Furthermore, MDMX expression promotes resistance to the chemotherapeutic agent 5-fluorouracil (5-FU), which at low concentrations activates p53 by inducing ribosomal stress without significant DNA damage signaling. Knockdown of MDMX abrogates HCT116 tumor xenograft formation in nude mice. MDMX overexpression does not accelerate tumor growth but increases resistance to 5-FU treatment in vivo. Therefore, MDMX is an important regulator of p53 response to ribosomal stress and RNA-targeting chemotherapy agents.

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Mdm2 and Mdmx bind many other proteins, including proteins involved in development, morphogenesis, and tumorigenesis.
“However, both Mdm2 and Mdmx interact with many other proteins, including those involved in development, morphogenesis and tumorigenesis (Table 2; [81–92]).”
From The p53 orchestra: Mdm2 and Mdmx set the tone (2010) · cites this paper as [88]

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Authors: Gilkes, D. M., Chen, L., & Chen, J.
Affiliations: Moffitt Cancer Center (US)
Corresponding author: Chen, Jiandong
ORCID: Gilkes, Daniele M
Chen, Lihong
Chen, Jiandong
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 2006-11-16
Volume: 25
Issue: 23
Pages: 5614-5625
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1038/sj.emboj.7601424
PMC: PMC1679771
OpenAlex: W2119121049
Cited by: 142
References: 57
Citations by year: 2025: 3 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 9 · 2015: 4 · 2014: 9 · 2013: 12 · 2012: 14
FWCI: 5.03
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: The EMBO Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Cancer Society
University of South Florida
National Institutes of Health
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: MDMX, p53, ribosomal stress, rRNA biogenesis, MDM2, p53 degradation, ribosomal proteins, nucleolus, actinomycin D, 5-fluorouracil, chemoresistance, tumor xenografts, growth arrest
MeSH terms: Animals, Antineoplastic Agents, Dactinomycin, DNA Damage, Female, Fluorouracil, Humans, Mice, Nude, Neoplasms, Nuclear Proteins, Proto-Oncogene Proteins, Ribosomal Proteins, Ribosomes, RNA, Ribosomal, Tumor Suppressor Protein p53, Cell Cycle Proteins, Drug Resistance, Neoplasm, Xenograft Model Antitumor Assays, Cell Line, Tumor, Cell Proliferation, Mice, Proto-Oncogene Proteins c-mdm2

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MDMX regulation of p53 response to ribosomal stress

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