The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines
Open accessAbstract
Mitogen-activated protein kinases (MAPK) are activated by phosphorylation on Thr and Tyr by MAPK kinases. Two MAPK kinases (MKK4 and MKK7) can activate the c-Jun NH 2-terminal kinase (JNK) group of MAPK in vitro. JNK is phosphorylated preferentially on Tyr by MKK4 and on Thr by MKK7. Targeted gene-disruption studies in mice were performed to examine the role of MKK4 and MKK7 in vivo. Simultaneous disruption of the Mkk4 and Mkk7 genes was required to block JNK activation caused by exposure of cells to environmental stress. In contrast, disruption of the Mkk7 gene alone was sufficient to prevent JNK activation caused by proinflammatory cytokines. These data demonstrate that MKK4 and MKK7 serve different functions in the JNK signal transduction pathway.
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Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1
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Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
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Self-citationMitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
Schaeffer, H. J., & Weber, M. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2435 · Cited by 1,600
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
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“Thus, in vitro assays demonstrate that MKK4 can activate both JNK and p38 MAPK (Derijard et al. 1995; Lin et al. 1995).”
BackgroundSelf-citationWhitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543
Self-citationTranslocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage
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ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
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Cellular response to oxidative stress: Signaling for suicide and survival*
Martindale, J. L., & Holbrook, N. J. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10119 · Cited by 2,297
The JNK signal transduction pathway
Weston, C. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00258-1 · Cited by 1,528
Mitogen-activated protein kinases in apoptosis regulation
Wada, T., & Penninger, J. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207556 · Cited by 1,432
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
Lei, K., & Davis, R. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438011100 · Cited by 1,068
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Metadata
- Authors
- Tournier, C., Dong, C., Turner, T. K., Jones, S. N., Flavell, R. A., & Davis, R. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-06-01
- Volume
- 15
- Issue
- 11
- Pages
- 1419-1426
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2104896634
- Cited by
- 359
- References
- 8
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Tournier, C., Dong, C., Turner, T. K., Jones, S. N., Flavell, R. A., & Davis, R. J. (2001). MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes & Development. https://doi.org/10.1101/gad.888501
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