The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The POU domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse.
Open accessAbstract
We generated mice carrying a loss-of-function mutation in Brn-2, a gene encoding a nervous system specific POU transcription factor, by gene targeting in embryonic stem cells. In homozygous mutant embryos, migratory precursor cells for neurons of the paraventricular nuclei (PVN) and the supraoptic nuclei (SO) of the hypothalamus die at approximately E12.5. All homozygous mutants suffered mortality within 10 days after birth, possibly because of a complete deficiency of these neurons in the hypothalamus. Although neither developmental nor histological abnormalities were observed in heterozygous mice, the levels of expression of vasopressin and oxytocin in the hypothalamus of these animals were half these of wild-type mice. These results strongly suggest that Brn-2 plays an essential role in the determination and development of the PVN and SO neuronal lineages in the hypothalamus.
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Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need
Muglia, L., Jacobson, L., Dikkes, P., & Majzoub, J. A. (1995) · Nature · doi:10.1038/373427a0 · Cited by 524
Sausville, E., Carney, D., & Battey, J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39236-0 · Cited by 338
Cited by
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
Chang, G.-Q., Gaysinskaya, V., Karatayev, O., & Leibowitz, S. F. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2642-08.2008 · Cited by 372
Gene Regulation in the Magnocellular Hypothalamo-Neurohypophysial System
Burbach, J. P. H., Luckman, S. M., Murphy, D., & Gainer, H. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1197 · Cited by 340
Essential role of POU–domain factor Brn-3c in auditory and vestibular hair cell development
Xiang, M., Gan, L., Li, D., Chen, Z.-Y., Zhou, L., O’Malley, B. W., Klein, W., & Nathans, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9445 · Cited by 334
Michaud, J. L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.14.1465 · Cited by 326
Metadata
- Authors
- Nakai, S., Kawano, H., Yudate, T., Nishi, M., Kuno, J., Nagata, A., Jishage, K., Hamada, H., Fujii, H., & Kawamura, K.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1995-12-15
- Volume
- 9
- Issue
- 24
- Pages
- 3109-3121
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2042289885
- Cited by
- 266
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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- The paper
- Nakai, S., Kawano, H., Yudate, T., Nishi, M., Kuno, J., Nagata, A., Jishage, K., Hamada, H., Fujii, H., & Kawamura, K. (1995). The POU domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse. Genes & Development. https://doi.org/10.1101/gad.9.24.3109
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