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Cited by 276

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.

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Donehower, L A, Godley, L A, Aldaz, C M, Pyle, R, Shi, Y P, Pinkel, D, Gray, J, Bradley, A, Medina, D, Varmus, H E·1995·Genes & Development
DOI 10.1101/gad.9.7.882
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Abstract

By crossing mice that carry a null allele of p53 with transgenic mice that develop mammary adenocarcinomas under the influence of a Wnt-1 transgene, we have studied the consequences of p53 deficiency in mammary gland neoplasia. In Wnt-1 transgenic mice homozygous for the p53 null allele, tumors appear at an earlier age than in animals heterozygous or wild-type at the p53 locus. About half of the tumors arising in p53 heterozygotes exhibit loss of the normal p53 allele, implying selection for p53-deficient cells. Mammary tumors lacking p53 display less fibrotic histopathology and increased genomic instability with aneuploidy, amplifications, and deletions, as detected by karyotype analysis and comparative genomic hybridization. In one tumor, the amplified region of chromosome 7 had an ectopically expressed int-2/FGF3 proto-oncogene, a gene known to cooperate with Wnt-1 in the production of mammary tumors. These findings favor a model in which p53 deficiency relaxes normal restraints on chromosomal number and organization during tumorigenesis.

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Metadata

Authors
Donehower, L. A., Godley, L. A., Aldaz, C. M., Pyle, R., Shi, Y. P., Pinkel, D., Gray, J., Bradley, A., Medina, D., & Varmus, H. E.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
1995-04-01
Volume
9
Issue
7
Pages
882-895
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.9.7.882
OpenAlex
W2143324424
Cited by
276
References
8
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. https://app.cochat.ai/papers/10.1101/gad.9.7.882
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Donehower, L. A., Godley, L. A., Aldaz, C. M., Pyle, R., Shi, Y. P., Pinkel, D., Gray, J., Bradley, A., Medina, D., & Varmus, H. E. (1995). Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes & Development. https://doi.org/10.1101/gad.9.7.882

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