The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Tissue-specific deletion of Foxa2 in pancreatic β cells results in hyperinsulinemic hypoglycemia
Open accessAbstract
We have used conditional gene ablation to uncover a dramatic and unpredicted role for the winged-helix transcription factor Foxa2 (formerly HNF-3β) in pancreatic β-cell differentiation and metabolism. Mice that lack Foxa2 specifically in β cells (Foxa2loxP/loxP; Ins.Cre mice) are severely hypoglycemic and show dysregulated insulin secretion in response to both glucose and amino acids. This inappropriate hypersecretion of insulin in the face of profound hypoglycemia mimics pathophysiological and molecular aspects of familial hyperinsulinism. We have identified the two subunits of the β-cell ATP-sensitive K+ channel (K ATP), the most frequently mutated genes linked to familial hyperinsulinism, as novel Foxa2 targets in islets. The Foxa2loxP/loxP; Ins.Cre mice will serve as a unique model to investigate the regulation of insulin secretion by the β cell and suggest the human FOXA2 as a candidate gene for familial hyperinsulinism.
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Thomas, P. M., Cote, G. J., Wohllk, N., Haddad, B., Mathew, P. M., Rabl, W., Aguilar-Bryan, L., Gagel, R. F., & Bryan, J. (1995) · Science · doi:10.1126/science.7716548 · Cited by 806
Ang, S.-L., Wierda, A., Wong, D., Stevens, K. A., Cascio, S., Rossant, J., & Zaret, K. S. (1993) · Development · doi:10.1242/dev.119.4.1301 · Cited by 618 · cited 2×
“During formation of the definite endoderm from which the pancreatic primordium is derived, Foxa2 mRNA is detected first, followed by Foxa1 and finally Foxa3 (Ang et al. 1993; Monaghan et al. 1993; Sasaki and Hogan 1993).”
BackgroundSelf-citationNotochord to endoderm signaling is required for pancreas development
Kim, S. K., Hebrok, M., & Melton, D. A. (1997) · Development · doi:10.1242/dev.124.21.4243 · Cited by 405
Insulin within islets is a physiologic glucagon release inhibitor
Maruyama, H., Hisatomi, A., Orci, L., Grodsky, G. M., & Unger, R. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111658 · Cited by 303
Cited by
Glucagon-like peptide 1 (GLP-1)
Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868
Pancreas organogenesis: From bud to plexus to gland
Pan, F. C., & Wright, C. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22584 · Cited by 614
Developmental biology of the pancreas: A comprehensive review
Gittes, G. K. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.024 · Cited by 451
Volkmar, M., Dedeurwaerder, S., Cunha, D. A., Ndlovu, M. N., Defrance, M., Deplus, R., Calonne, E., Volkmar, U., Igoillo‐Esteve, M., Naamane, N., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.503 · Cited by 420
“FOXA2 ( HNF3B ) is part of a transcription factor network regulating β -cell differentiation (Lee et al , 2002; Sund et al , 2001).”
MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic β-Cell Lines*
Baroukh, N., Ravier, M. A., Loder, M. K., Hill, E. V., Bounacer, A., Scharfmann, R., Rutter, G. A., & Van Obberghen, E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611841200 · Cited by 326
Metadata
- Authors
- Sund, N. J., Vatamaniuk, M. Z., Casey, M., Ang, S.-L., Magnuson, M. A., Stoffers, D. A., Matschinsky, F. M., & Kaestner, K. H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-07-01
- Volume
- 15
- Issue
- 13
- Pages
- 1706-1715
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2112163906
- Cited by
- 186
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Sund, N. J., Vatamaniuk, M. Z., Casey, M., Ang, S.-L., Magnuson, M. A., Stoffers, D. A., Matschinsky, F. M., & Kaestner, K. H. (2001). Tissue-specific deletion of Foxa2 in pancreatic β cells results in hyperinsulinemic hypoglycemia. Genes & Development. https://doi.org/10.1101/gad.901601
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
