The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation
Open accessAbstract
The Myc protein binds DNA and activates transcription by mechanisms that are still unclear. We used chromatin immunoprecipitation (ChIP) to evaluate Myc-dependent changes in histone acetylation at seven target loci. Upon serum stimulation of Rat1 fibroblasts, Myc associated with chromatin, histone H4 became locally hyperacetylated, and gene expression was induced. These responses were lost or severely impaired in Myc-deficient cells, but were restored by adenoviral delivery of Myc simultaneous with mitogenic stimulation. When targeted to chromatin in the absence of mitogens, Myc directly induced H4 acetylation. In addition, Myc recruited TRRAP to chromatin, consistent with a role for this cofactor in histone acetylation. Finally, unlike serum, Myc alone was very inefficient in inducing expression of most target genes. Myc therefore governs a step, most likely H4 acetylation, that is required but not sufficient for transcriptional activation. We propose that Myc acts as a permissive factor, allowing additional signals to activate target promoters.
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Cites
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Cited by
The transcriptional network for mesenchymal transformation of brain tumours
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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
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MYC as a regulator of ribosome biogenesis and protein synthesis
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c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function
Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation
Wilson, A., Murphy, M. J., Oskarsson, T., Kaloulis, K., Bettess, M. D., Oser, G. M., Pasche, A.-C., Knabenhans, C., MacDonald, H. R., & Trumpp, A. (2004) · Genes & Development · doi:10.1101/gad.313104 · Cited by 823
Metadata
- Authors
- Frank, S. R., Schroeder, M., Fernandez, P., Taubert, S., & Amati, B.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-08-15
- Volume
- 15
- Issue
- 16
- Pages
- 2069-2082
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2144691110
- Cited by
- 499
- References
- 59
- Type
- posted content
- Language
- en
- Open access
- diamond
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