The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint
Open accessAbstract
The spindle checkpoint prevents cell cycle progression in cells that have mitotic spindle defects. Although several spindle defects activate the spindle checkpoint, the exact nature of the primary signal is unknown. We have found that the budding yeast member of the Aurora protein kinase family, Ipl1p, is required to maintain a subset of spindle checkpoint arrests. Ipl1p is required to maintain the spindle checkpoint that is induced by overexpression of the protein kinase Mps1. Inactivating Ipl1p allows cells overexpressing Mps1p to escape from mitosis and segregate their chromosomes normally. Therefore, the requirement for Ipl1p in the spindle checkpoint is not a consequence of kinetochore and/or spindle defects. The requirement for Ipl1p distinguishes two different activators of the spindle checkpoint: Ipl1p function is required for the delay triggered by chromosomes whose kinetochores are not under tension, but is not required for arrest induced by spindle depolymerization. Ipl1p localizes at or near kinetochores during mitosis, and we propose that Ipl1p is required to monitor tension at the kinetochore.
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Cites
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The spindle-assembly checkpoint in space and time
Musacchio, A., & Salmon, E. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2163 · Cited by 2,227
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The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
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Metadata
- Authors
- Biggins, S., & Murray, A. W.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-12-01
- Volume
- 15
- Issue
- 23
- Pages
- 3118-3129
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2170145644
- Cited by
- 408
- References
- 67
- Type
- posted content
- Language
- en
- Open access
- diamond
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