The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
c(3)G encodes a Drosophila synaptonemal complex protein
Open accessAbstract
The meiotic mutant c(3)G (c rossover suppressor on 3 of G owen) abolishes both synaptonemal complex (SC) formation and meiotic recombination, whereas mutations in the mei-W68 and mei-P22 genes prevent recombination but allow normal SC to form. These data, as well as a century of cytogenetic studies, support the argument that meiotic recombination between homologous chromosomes in Drosophila females requires synapsis and SC formation. We have cloned the c(3)G gene and shown that it encodes a protein that is structurally similar to SC proteins from yeast and mammals. Immunolocalization of the C(3)G protein, as well as the analysis of a C(3)G-eGFP expression construct, reveals that C(3)G is present in a thread-like pattern along the lengths of chromosomes in meiotic prophase, consistent with a role as an SC protein present on meiotic bivalents. The availability of a marker for SC in Drosophila allowed the investigation of the extent of synapsis in exchange-defective mutants. These studies indicate that SC formation is impaired in certain meiotic mutants and that the synaptic defect correlates with the exchange defects. Moreover, the observation of interference among the residual exchanges in these mutant oocytes implies that complete SC formation is not required for crossover interference in Drosophila.
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The Genome Sequence of Drosophila melanogaster
Adams, M. D., Celniker, S. E., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S. E., Li, P. W., Hoskins, R. A., Galle, R. F., et al. (2000) · Science · doi:10.1126/science.287.5461.2185 · Cited by 5,929
Predicting coiled coils from protein sequences.
Lupas, A., Van Dyke, M., & Stock, J. (1991) · Science · doi:10.1126/science.252.5009.1162 · Cited by 3,953
The Genome of Drosophila Melanogaster
Lindsley, D. L., & Zimm, G. G. (1992) · Cited by 3,098
Comparative Genomics of the Eukaryotes
Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science · doi:10.1126/science.287.5461.2204 · Cited by 1,698 · cited 3×
“Several transcripts from this region were identified by expressed sequence tags from the Berkeley Drosophila Genome Project (Rubin et al. 2000).”
BackgroundMethodInfluentialMeiotic Chromosomes: Integrating Structure and Function
Zickler, D., & Kleckner, N. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.603 · Cited by 1,255
Meiotic chromosomes: it takes two to tango
Roeder, G. S. (1997) · Genes & Development · doi:10.1101/gad.11.20.2600 · Cited by 805
Dernburg, A. F., McDonald, K., Moulder, G., Barstead, R., Dresser, M., & Villeneuve, A. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81481-6 · Cited by 772
Chapter 13 Fluorescence Microscopy in Three Dimensions
Agard, D. A., Hiraoka, Y., Shaw, P., & Sedat, J. W. (1989) · Methods in Cell Biology · doi:10.1016/s0091-679x(08)60986-3 · Cited by 649
ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis
Sym, M., Engebrecht, J., & Roeder, G. S. (1993) · Cell · doi:10.1016/0092-8674(93)90114-6 · Cited by 598
THE SYNAPTONEMAL COMPLEX IN GENETIC SEGREGATION
von Wettstein, D., Rasmussen, S. W., & Holm, P. B. (1984) · Annual Review of Genetics · doi:10.1146/annurev.ge.18.120184.001555 · Cited by 590
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THE GENETICS AND MOLECULAR BIOLOGY OF THE SYNAPTONEMAL COMPLEX
Page, S. L., & Hawley, R. S. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.155141 · Cited by 709
Self-citationVersatile design and synthesis platform for visualizing genomes with Oligopaint FISH probes
Beliveau, B. J., Joyce, E. F., Apostolopoulos, N., Yilmaz, F., Fonseka, C. Y., McCole, R. B., Chang, Y., Li, J. B., Senaratne, T. N., Williams, B. R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213818110 · Cited by 458
Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation
de Vries, F. A. T., de Boer, E., van den Bosch, M., Baarends, W. M., Ooms, M., Yuan, L., Liu, J.-G., van Zeeland, A. A., Heyting, C., & Pastink, A. (2005) · Genes & Development · doi:10.1101/gad.329705 · Cited by 455
Lim, A. K., & Kai, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701920104 · Cited by 369
Heterochromatic Genome Stability Requires Regulators of Histone H3 K9 Methylation
Peng, J. C., & Karpen, G. H. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000435 · Cited by 183
Metadata
- Authors
- Page, S. L., & Hawley, R. S.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-12-01
- Volume
- 15
- Issue
- 23
- Pages
- 3130-3143
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2111481274
- Cited by
- 305
- References
- 43
- Type
- posted content
- Language
- en
- Open access
- diamond
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