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Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord
Open accessAbstract
In the developing spinal cord, signals from the roof plate are required for the development of three classes of dorsal interneuron: D1, D2, and D3, listed from dorsal to ventral. Here, we demonstrate that absence of Wnt1 and Wnt3a, normally expressed in the roof plate, leads to diminished development of D1 and D2 neurons and a compensatory increase in D3 neuron populations. This occurs without significantly altered expression of BMP and related genes in the roof plate. Moreover, Wnt3a protein induces expression of D1 and D2 markers in the isolated medial region of the chick neural plate, and Noggin does not interfere with this induction. Thus, Wnt signaling plays a critical role in the specification of cell types for dorsal interneurons.
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Citations
Cites
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Cited by
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Establishing neuronal diversity in the spinal cord: a time and a place
Sagner, A., & Briscoe, J. (2019) · Development · doi:10.1242/dev.182154 · Cited by 281
The mechanisms of dorsoventral patterning in the vertebrate neural tube
Wilson, L., & Maden, M. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.02.027 · Cited by 276
Making sense out of spinal cord somatosensory development
Lai, H. C., Seal, R. P., & Johnson, J. E. (2016) · Development · doi:10.1242/dev.139592 · Cited by 188
Coordinate regulation of neural tube patterning and proliferation by TGFβ and WNT activity
Chesnutt, C., Burrus, L. W., Brown, A. M. C., & Niswander, L. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.07.019 · Cited by 152
Metadata
- Authors
- Muroyama, Y., Fujihara, M., Ikeya, M., Kondoh, H., & Takada, S.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-03-01
- Volume
- 16
- Issue
- 5
- Pages
- 548-553
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1968707675
- Cited by
- 288
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Muroyama, Y., Fujihara, M., Ikeya, M., Kondoh, H., & Takada, S. (2002). Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes & Development. https://doi.org/10.1101/gad.937102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
