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The mechanisms of dorsoventral patterning in the vertebrate neural tube

Wilson, Leigh, Maden, Malcolm·2005·Developmental Biology
DOI 10.1016/j.ydbio.2005.02.027
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Abstract

We describe the essential features of and the molecules involved in dorsoventral (DV) patterning in the neural tube. The neural tube is, from its very outset, patterned in this axis as there is a roof plate, floor plate, and differing numbers and types of neuroblasts. These neuroblasts develop into different types of neurons which express a different range of marker genes. Early embryological experiments identified the notochord and the somites as being responsible for the DV patterning of the neural tube and we now know that 4 signaling molecules are involved and are generated by these surrounding structures. Fibroblast growth factors (FGFs) are produced by the caudal mesoderm and must be down-regulated before neural differentiation can occur. Retinoic acid (RA) is produced by the paraxial mesoderm and is an inducer of neural differentiation and patterning and is responsible for down-regulating FGF. Sonic hedgehog (Shh) is produced by the notochord and floor plate and is responsible for inducing ventral neural cell types in a concentration-dependent manner. Bone morphogenetic proteins (BMPs) are produced by the roof plate and are responsible for inducing dorsal neural cell types in a concentration-dependent manner. Subsequently, RA is used twice more. Once from the somites for motor neuron differentiation and secondly RA is used to define the motor neuron subtypes, but in the latter case it is generated within the neural tube from differentiating motor neurons rather than fr…

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  • SHH, secreted by the notochord and floor plate, forms a morphogen gradient from ventral to dorsal neural tube and, in conjunction with other morphogens, specifies neuronal cell fates.

    “SHH, secreted by the notochord and floor plate, forms a morphogen gradient from ventral to dorsal neural tube and, in conjunction with concentration gradients of other morphogens such as Nodal and BMPs, specifies neuronal cell fates”

    From Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development (2016) · cites this paper as [60]

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Authors
Wilson, L., & Maden, M.
Venue
Developmental Biology
Publisher
Elsevier BV
Published
2005-06
Volume
282
Issue
1
Pages
1-13
ISSN
0012-1606
DOI
10.1016/j.ydbio.2005.02.027
Cited by
276
References
2
Language
en
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