The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Global distribution of genomic diversity underscores rich complex history of continental human populations
Open accessAbstract
Characterizing patterns of genetic variation within and among human populations is important for understanding human evolutionary history and for careful design of medical genetic studies. Here, we analyze patterns of variation across 443,434 single nucleotide polymorphisms (SNPs) genotyped in 3845 individuals from four continental regions. This unique resource allows us to illuminate patterns of diversity in previously under-studied populations at the genome-wide scale including Latin America, South Asia, and Southern Europe. Key insights afforded by our analysis include quantifying the degree of admixture in a large collection of individuals from Guadalajara, Mexico; identifying language and geography as key determinants of population structure within India; and elucidating a north–south gradient in haplotype diversity within Europe. We also present a novel method for identifying long-range tracts of homozygosity indicative of recent common ancestry. Application of our approach suggests great variation within and among populations in the extent of homozygosity, suggesting both demographic history (such as population bottlenecks) and recent ancestry events (such as consanguinity) play an important role in patterning variation in large modern human populations.
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Cites
Population Structure and Eigenanalysis
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A second generation human haplotype map of over 3.1 million SNPs
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Self-citationMapping and sequencing of structural variation from eight human genomes
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Self-citationGeographic Patterns of Genome Admixture in Latin American Mestizos
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Y genetic data support the Neolithic demic diffusion model
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Self-citationA Genomewide Admixture Map for Latino Populations
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Cited by
Tracing the peopling of the world through genomics
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Hunter-gatherer genomic diversity suggests a southern African origin for modern humans
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Self-citationThe genetics of Mexico recapitulates Native American substructure and affects biomedical traits
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Self-citationThe Geography of Recent Genetic Ancestry across Europe
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Genetic Evidence for Recent Population Mixture in India
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Metadata
- Authors
- Auton, A., Bryc, K., Boyko, A. R., Lohmueller, K. E., Novembre, J., Reynolds, A., Indap, A., Wright, M. H., Degenhardt, J. D., Gutenkunst, R. N., King, K. S., Nelson, M. R., & Bustamante, C. D.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-02-13
- Volume
- 19
- Issue
- 5
- Pages
- 795-803
- ISSN
- 1088-9051 (ISSN-L)
- OpenAlex
- W2026323344
- Cited by
- 166
- References
- 11
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Auton, A., Bryc, K., Boyko, A. R., Lohmueller, K. E., Novembre, J., Reynolds, A., Indap, A., Wright, M. H., Degenhardt, J. D., Gutenkunst, R. N., King, K. S., Nelson, M. R., & Bustamante, C. D. (2009). Global distribution of genomic diversity underscores rich complex history of continental human populations. Genome Research. https://doi.org/10.1101/gr.088898.108
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