A Genomewide Admixture Map for Latino Populations
Open accessAbstract
Admixture mapping is an economical and powerful approach for localizing disease genes in populations of recently mixed ancestry and has proven successful in African Americans. The method holds equal promise for Latinos, who typically inherit a mix of European, Native American, and African ancestry. However, admixture mapping in Latinos has not been practical because of the lack of a map of ancestry-informative markers validated in Native American and other populations. To address this, we screened multiple databases, containing millions of markers, to identify 4,186 markers that were putatively informative for determining the ancestry of chromosomal segments in Latino populations. We experimentally validated each of these markers in at least 232 new Latino, European, Native American, and African samples, and we selected a subset of 1,649 markers to form an admixture map. An advantage of our strategy is that we focused our map on markers distinguishing Native American from other ancestries and restricted it to markers with very similar frequencies in Europeans and Africans, which decreased the number of markers needed and minimized the possibility of false disease associations. We evaluated the effectiveness of our map for localizing disease genes in four Latino populations from both North and South America.
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Mexicans descend from a recent mix of Amerindian and European ancestry, which has caused marked differences in allelic frequencies and patterns of LD across their genome.
“Mexicans descend from a recent mix of Amerindian and European ancestry, which has caused marked differences in allelic frequencies and patterns of LD across their genome (19).”
From The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans (2011) · cites this paper as [19]
The Results report substantial Native American and European ancestry in the sampled Mexicans and estimate an average of 8.8 generations since admixture. The paper discusses ancestry-informative allele frequencies and greater LD in Native American populations, but does not establish that admixture caused marked differences in allele frequencies and LD patterns across Mexicans’ genomes. No page numbers are available in our copy. (LLM, conf=0.85)
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Sensitive detection of chromosomal segments of distinct ancestry in admixed populations
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- Authors
- Price, A. L., Patterson, N., Yu, F., Cox, D. R., Waliszewska, A., McDonald, G. J., Tandon, A., Schirmer, C., Neubauer, J., Bedoya, G., Duque, C., Villegas, A., Bortolini, M. C., Salzano, F. M., Gallo, C., Mazzotti, G., Tello-Ruiz, M., Riba, L., Aguilar-Salinas, C. A., Canizales-Quinteros, S., Menjivar, M., Klitz, W., Henderson, B., Haiman, C. A., Winkler, C., Tusie-Luna, T., Ruiz-Linares, A., & Reich, D.
- Affiliations
- Harvard University (US)
- Broad Institute (US)
- Perlegen (United States) (US)
- Universidad de Antioquia (CO)
- Universidade Federal do Rio Grande do Sul (BR)
- Universidad Peruana Cayetano Heredia (PE)
- Public Health Institute (US)
- University of Southern California (US)
- National Cancer Institute (US)
- Corresponding author
- Reich, David
- ORCID
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 80
- Issue
- 6
- Pages
- 1024-1036
- ISSN
- 0002-9297 (ISSN-L)
- PMC
- PMC1867092
- OpenAlex
- W2082854754
- Cited by
- 282
- References
- 4
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 11 · 2019: 8 · 2018: 16 · 2017: 12 · 2016: 16 · 2015: 11 · 2014: 34 · 2013: 19 · 2012: 29
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The American Journal of Human Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository University of Antioquia (University of Antioquia) (publishedVersion, cc-by-nc-nd)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Universidad Peruana Cayetano Heredia Institutional Repository (submittedVersion, cc-by-nc-nd)
- Funders
- Broad Institute
- Ministerio de Economía y Competitividad
- National Institutes of Health (n01co12400-79-0-22, 6u54rr020278-06)
- National Cancer Institute (N01CO12400, N01-CO-012400)
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK076277, R21DK073818, DK073818)
- National Institute of Neurological Disorders and Stroke (NS043538, R01NS043538)
- National Center for Research Resources (U54-RR020278, U54RR020278-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Race, Genetics, and Society
- Keywords
- admixture mapping, Latino population, ancestry informative markers, Native American ancestry, disease gene localization, genetic ancestry, European ancestry, African ancestry
- MeSH terms
- Alleles, Black or African American, Chromosome Mapping, Chromosomes, Human, Computer Simulation, Genetic Markers, Genetic Testing, Genetics, Population, Hispanic or Latino, Humans, Indians, North American, Reproducibility of Results, Genome, Human, Case-Control Studies, Genetic Predisposition to Disease, Databases, Genetic, Black People, White People
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