The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Reconstruction and Validation of Saccharomyces cerevisiae iND750, a Fully Compartmentalized Genome-Scale Metabolic Model
Open accessAbstract
A fully compartmentalized genome-scale metabolic model of Saccharomyces cerevisiae that accounts for 750 genes and their associated transcripts, proteins, and reactions has been reconstructed and validated. All of the 1149 reactions included in this in silico model are both elementally and charge balanced and have been assigned to one of eight cellular locations (extracellular space, cytosol, mitochondrion, peroxisome, nucleus, endoplasmic reticulum, Golgi apparatus, or vacuole). When in silico predictions of 4154 growth phenotypes were compared to two published large-scale gene deletion studies, an 83% agreement was found between iND750's predictions and the experimental studies. Analysis of the failure modes showed that false predictions were primarily caused by iND750's limited inclusion of cellular processes outside of metabolism. This study systematically identified inconsistencies in our knowledge of yeast metabolism that require specific further experimental investigation.
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Self-citationAn expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)
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Self-citationModelling and analysis of gene regulatory networks
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Metadata
- Authors
- Duarte, N. C., Herrgård, M. J., & Palsson, B. Ø.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-06-14
- Volume
- 14
- Issue
- 7
- Pages
- 1298-1309
- ISSN
- 1088-9051 (ISSN-L)
- OpenAlex
- W2048214825
- Cited by
- 639
- References
- 46
- Type
- posted content
- Language
- en
- Open access
- bronze
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