The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Sequence Mapping by Electronic PCR
Open accessAbstract
The highly specific and sensitive PCR provides the basis for sequence-tagged sites (STSs), unique landmarks that have been used widely in the construction of genetic and physical maps of the human genome. Electronic PCR (e-PCR) refers to the process of recovering these unique sites in DNA sequences by searching for subsequences that closely match the PCR primers and have the correct order, orientation, and spacing that they could plausibly prime the amplification of a PCR product of the correct molecular weight. A software tool was developed to provide an efficient implementation of this search strategy and allow the sort of en masse searching that is required for modern genome analysis. Some sample searches were performed to demonstrate a number of factors that can affect the likelihood of obtaining a match. Analysis of one large sequence database record revealed the presence of several microsatellite and gene-based markers and allowed the exact base-pair distances among them to be calculated. This example provides a demonstration of how e-PCR can be used to integrate the growing body of genomic sequence data with existing maps, reveal relationships among markers that existed previously on different maps, and correlate genetic distances with physical distances.
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Cites
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A comprehensive genetic map of the human genome based on 5,264 microsatellites
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Self-citationA Common Language for Physical Mapping of the Human Genome
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Issues in searching molecular sequence databases
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An STS-Based Map of the Human Genome
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A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
Dietzl, G., Chen, D., Schnorrer, F., Su, K.-C., Barinova, Y., Fellner, M., Gasser, B., Kinsey, K., Oppel, S., Scheiblauer, S., et al. (2007) · Nature · doi:10.1038/nature05954 · Cited by 2,644
A new version of the grapevine reference genome assembly (12X.v2) and of its annotation (VCost.v3)
Canaguier, A., Grimplet, J., Di Gaspero, G., Scalabrin, S., Duchêne, E., Choisne, N., Mohellibi, N., Guichard, C., Rombauts, S., Le Clainche, I., et al. (2017) · Genomics Data · doi:10.1016/j.gdata.2017.09.002 · Cited by 322
GMATA: An Integrated Software Package for Genome-Scale SSR Mining, Marker Development and Viewing
Wang, X., & Wang, L. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01350 · Cited by 283
Treutlein, J., Kissling, C., Frank, J., Wiemann, S., Dong, L., Depner, M., Saam, C., Lascorz, J., Soyka, M., Preuss, U. W., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001813 · Cited by 186
Structure and evolutionary history of a large family of NLR proteins in the zebrafish
Howe, K., Schiffer, P. H., Zielinski, J., Wiehe, T., Laird, G. K., Marioni, J. C., Soylemez, O., Kondrashov, F., & Leptin, M. (2016) · Open Biology · doi:10.1098/rsob.160009 · Cited by 137
Metadata
- Authors
- Schuler, G. D.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1997-05-01
- Volume
- 7
- Issue
- 5
- Pages
- 541-550
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- OpenAlex
- W2106538287
- Cited by
- 373
- References
- 15
- Type
- posted content
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Sequence Mapping by Electronic PCR. https://app.cochat.ai/papers/10.1101/gr.7.5.541
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- Schuler, G. D. (1997). Sequence Mapping by Electronic PCR. Genome Research. https://doi.org/10.1101/gr.7.5.541
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