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Large-Scale Discovery of Induced Point Mutations With High-Throughput TILLING
Open accessAbstract
TILLING (T argeting I nduced L ocal L esions inG enomes) is a general reverse-genetic strategy that provides an allelic series of induced point mutations in genes of interest. High-throughput TILLING allows the rapid and low-cost discovery of induced point mutations in populations of chemically mutagenized individuals. As chemical mutagenesis is widely applicable and mutation detection for TILLING is dependent only on sufficient yield of PCR products, TILLING can be applied to most organisms. We have developed TILLING as a service to the Arabidopsis community known as the Arabidopsis TILLING Project (ATP). Our goal is to rapidly deliver allelic series of ethylmethanesulfonate-induced mutations in target 1-kb loci requested by the international research community. In the first year of public operation, ATP has discovered, sequenced, and delivered >1000 mutations in >100 genes ordered by Arabidopsis researchers. The tools and methodologies described here can be adapted to create similar facilities for other organisms.
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Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Véronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., André, B., et al. (2002) · Nature · doi:10.1038/nature00935 · Cited by 4,316
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Efficient discovery of DNA polymorphisms in natural populations by Ecotilling
Comai, L., Young, K., Till, B. J., Reynolds, S. H., Greene, E. A., Codomo, C. A., Enns, L. C., Johnson, J. E., Burtner, C., Odden, A. R., et al. (2004) · The Plant Journal · doi:10.1111/j.0960-7412.2003.01999.x · Cited by 451
Self-citationEnhancing genetic gain in the era of molecular breeding
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TILLING to detect induced mutations in soybean
Cooper, J. L., Till, B. J., Laport, R. G., Darlow, M. C., Kleffner, J. M., Jamai, A., El-Mellouki, T., Liu, S., Ritchie, R., Nielsen, N., et al. (2008) · BMC Plant Biology · doi:10.1186/1471-2229-8-9 · Cited by 300
Self-citationInvasion by Invitation: Rhizobial Infection in Legumes
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Metadata
- Authors
- Till, B. J., Reynolds, S. H., Greene, E. A., Codomo, C. A., Enns, L. C., Johnson, J. E., Burtner, C., Odden, A. R., Young, K., Taylor, N. E., Henikoff, J. G., Comai, L., & Henikoff, S.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-03-01
- Volume
- 13
- Issue
- 3
- Pages
- 524-530
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- OpenAlex
- W2135777982
- Cited by
- 607
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Till, B. J., Reynolds, S. H., Greene, E. A., Codomo, C. A., Enns, L. C., Johnson, J. E., Burtner, C., Odden, A. R., Young, K., Taylor, N. E., Henikoff, J. G., Comai, L., & Henikoff, S. (2003). Large-Scale Discovery of Induced Point Mutations With High-Throughput TILLING. Genome Research. https://doi.org/10.1101/gr.977903
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