Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats
Abstract
We previously showed that dietary cytidine (5′)-diphosphocholine (CDP-choline) supplementation could protect against the development of memory deficits in aging rats. In the present study, younger rats exposed to impoverished environmental conditions and manifesting hippocampal-dependent memory impairments similar to those observed in the aging rodents were given CDP-choline, and its effects on this cognitive deficit were assessed. Male Sprague-Dawley rats reared for 3 mo in impoverished (IC) or enriched environmental (EC) conditions concurrently received either a control diet or a diet supplemented with CDP-choline (∼500 mg/kg/d). After 3 mo, rats were trained to perform spatial and cued versions of the Morris water maze, and their rates of acquisition and retention were compared. Impoverished rats exhibited a selective deficit in hippocampal-dependent spatial memory which could be ameliorated by feeding them CDP-choline. The CDP-choline had no memory-enhancing effect in enriched rats, nor did it prevent the memory impairment of impoverished rats if the animals consumed it for the initial or final months instead of for the entire 3-mo period. These findings indicate that long-term dietary CDP-choline supplementation can ameliorate the hippocampal-dependent memory impairment caused by impoverished environmental conditions in rats, and suggest that its actions result, in part, from a long-term effect such as enhanced membrane phosphatide synthesis, an effect shown to require long-term dietary supplementation with CDP-choline.
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Studies have shown benefits of dietary choline intake and supplementation on cognitive performance in human individuals and in animal models.
“This finding aligns with studies showing benefits of dietary choline intake and supplementation on cognitive performance in human individuals and in animal models71–78.”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [73]
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Hirsch, M. J., Growdon, J. H., & Wurtman, R. J. (1978) · Metabolism · doi:10.1016/0026-0495(78)90139-7 · Cited by 95 · see citing works
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- Hebb, D.O. 1949. The Organization of Behavior . Wiley, New York.
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Single-cell multiregion dissection of Alzheimer’s disease
Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07606-7 · Cited by 343 · see citing works
Li, W., Dowd, S. E., Scurlock, B., Acosta-Martinez, V., & Lyte, M. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.12.004 · Cited by 246 · see citing works
Wurtman, R. J., Ulus, I. H., Cansev, M., Watkins, C. J., Wang, L., & Marzloff, G. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.019 · Cited by 169 · see citing works
Self-citationDNA methylation impacts on learning and memory in aging
Liu, L., van Groen, T., Kadish, I., & Tollefsbol, T. O. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.020 · Cited by 152 · see citing works
Holguin, S., Huang, Y., Liu, J., & Wurtman, R. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.042 · Cited by 57 · see citing works
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- Authors
- Teather, L. A., & Wurtman, R. J.
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-01
- Volume
- 12
- Issue
- 1
- Pages
- 39-43
- ISSN
- 1072-0502
- 1549-5485
- Cited by
- 41
- References
- 1
- Language
- en
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