Cited by 152Epigenetics and DNA MethylationMemory and Neural MechanismsNeurogenesis and neuroplasticity mechanisms

DNA methylation impacts on learning and memory in aging

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Liu, Liang, van Groen, Thomas, Kadish, Inga, Tollefsbol, Trygve O.·2009·Neurobiology of Aging

Abstract

Learning and memory are two of the fundamental cognitive functions that confer us the ability to accumulate knowledge from our experiences. Although we use these two mental skills continuously, understanding the molecular basis of learning and memory is very challenging. Methylation modification of DNA is an epigenetic mechanism that plays important roles in regulating gene expression, which is one of the key processes underlying the functions of cells including neurons. Interestingly, a genome-wide decline in DNA methylation occurs in the brain during normal aging, which coincides with a functional decline in learning and memory with age. It has been speculated that DNA methylation in neurons might be involved in memory coding. However, direct evidence supporting the role of DNA methylation in memory formation is still under investigation. This particular function of DNA methylation has not drawn wide attention despite several important studies that have provided supportive evidence for the epigenetic control of memory formation. To facilitate further exploration of the epigenetic basis of memory function, we will review existing studies on DNA methylation that are related to the development and function of the nervous system. We will focus on studies illustrating how DNA methylation regulates neural activities and memory formation via the control of gene expression in neurons, and relate these studies to various age-related neurological disorders that affect cognitive functions.

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Crossref · 10.1016/j.neurobiolaging.2007.07.020

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Authors
Liu, L., van Groen, T., Kadish, I., & Tollefsbol, T. O.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Liu, Liang
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2009-04
Volume
30
Issue
4
Pages
549-560
ISSN
0197-4580 (ISSN-L)
OpenAlex
W1976478257
Cited by
152
References
137
Citations by year
2026: 4 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 4 · 2017: 12 · 2016: 5 · 2015: 6 · 2014: 11 · 2013: 14 · 2012: 12
FWCI
0.79
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R01CA129415)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
DNA methylation, learning and memory, brain aging, epigenetics, gene expression regulation, neurons, memory formation, age-related neurological disorders, cognitive decline, brain development
MeSH terms
Aging, Animals, Gene Expression Regulation, Humans, Learning, Learning Disabilities, Memory, Memory Disorders, DNA Methylation, Neurodegenerative Diseases, Epigenesis, Genetic

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