A role for prefrontal calcium-sensitive protein phosphatase and kinase activities in working memory
Abstract
The prefrontal cortex is involved in the integration and interpretation of information for directing thoughts and planning action. Working memory is defined as the active maintenance of information in mind and is thought to lie at the core of many prefrontal functions. Although dopamine and other neurotransmitters have been implicated, the intracellular events activated by their receptors that influence working memory are poorly understood. We demonstrate that working memory involves transient changes in prefrontal G q/11-signaling and in calcium-dependent intracellular protein phosphatase and kinase activity. Interestingly, inhibition of the calcium activated phosphatase calcineurin impaired, while calcium/calmodulin dependent kinase II (CaMKII) and calcium-dependent protein kinase C (PKC) enhanced, working memory. Our findings suggest that the active maintenance of information required for working memory involves transient changes in the balance of these enzymes' activities.
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In rodents, working memory deficits caused by pharmacological stress, cold water stress or administration of α1-agonists can be reversed by infusing PKC inhibitors directly into the prefrontal cortex.
“In rodents the working memory deficits that are caused by pharmacological stress, cold water stress or administration of α1-agonists can be reversed by infusing PKC inhibitors directly into the PFC61,88.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [88]
Cites
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“blockade of cAMP-dependent protein kinase A (PKA) activity by Rp-cAMPS did not influence working memory in a delay alternation task (Taylor et al. 1999).”
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- Authors
- Runyan, J. D., Moore, A. N., & Dash, P. K.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-03
- Volume
- 12
- Issue
- 2
- Pages
- 103-110
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- OpenAlex
- W2063709171
- Cited by
- 68
- References
- 3
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 2
- Type
- posted content
- Language
- en
- Open access
- closed
- Locations
- Learning & Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 35457, R01NS035457)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- working memory, prefrontal cortex, calcineurin, CaMKII, protein kinase C, calcium signaling, Gq/11 signaling, protein phosphatase, protein kinases, information maintenance
- MeSH terms
- Animals, Discrimination Learning, Male, Memory, Short-Term, Phosphoprotein Phosphatases, Protein Kinases, Time Perception, Signal Transduction, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, Dopamine D1, Calcium-Calmodulin-Dependent Protein Kinases, Calcium Signaling, GTP-Binding Protein alpha Subunits, Gq-G11, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 2
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