Molecular mechanisms of stress-induced prefrontal cortical impairment: Implications for mental illness

Hains, Avis B.; Arnsten, Amy F.T.

doi:10.1101/lm.921708

Cited by 127Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Molecular mechanisms of stress-induced prefrontal cortical impairment: Implications for mental illness

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Hains, Avis B., Arnsten, Amy F.T.·2008·Learning & Memory

DOI 10.1101/lm.921708

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Abstract

The symptoms of mental illness often involve weakened regulation of thought, emotion, and behavior by the prefrontal cortex. Exposure to stress exacerbates symptoms of mental illness and causes marked prefrontal cortical dysfunction. Studies in animals have revealed the intracellular signaling pathways activated by stress exposure that induce profound prefrontal cortical impairment: Excessive dopamine stimulation of D1 receptors impairs prefrontal function via cAMP intracellular signaling, leading to disconnection of prefrontal networks, while excessive norepinephrine stimulation of α1 receptors impairs prefrontal function via phosphatidylinositol–protein kinase C intracellular signaling. Genetic studies indicate that the genes disrupted in serious mental illness (bipolar disorder and schizophrenia) often encode for the intracellular proteins that serve as brakes on the intracellular stress pathways. For example, disrupted in schizophrenia 1 (DISC1) normally regulates cAMP levels, while regulator of G protein signaling 4 (RGS4) and diacylglycerol kinase (DGKH)—the molecule most associated with bipolar disorder— normally serve to inhibit phosphatidylinositol–protein kinase C intracellular signaling. Patients with mutations resulting in loss of adequate function of these genes likely have weaker endogenous regulation of these stress pathways. This may account for the vulnerability to stress and the severe loss of PFC regulation of behavior, thought, and affect in these illnesses. This review highlights the signaling pathways onto which genetic vulnerability and stress converge to impair PFC function and induce debilitating symptoms such as thought disorder, disinhibition, and impaired working memory.

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Depression, anxiety, substance use, intimate partner violence, body image concerns, and sexual compulsivity may represent final behavioral outcomes of the same or similar underlying neurological, cognitive, affective, and interpersonal stress pathways.
“depression and anxiety, substance use, intimate partner violence, body image concerns, and sexual compulsivity could be argued to represent final behavioral outcomes of the same or similar underlying neurological, cognitive, affective, and interpersonal stress pathways”
From A transdiagnostic minority stress treatment approach for gay and bisexual men's syndemic health conditions (2015) · cites this paper as Hains & Arnsten, 2008

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Self-citation
Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction
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Stress weakens prefrontal networks: molecular insults to higher cognition
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Self-citation
Cerebral Cortex 2007;17:i6--i15 doi:10.1093/cercor/bhm033 Catecholamine and Second Messenger Influences on Prefrontal Cortical Networks of ‘‘Representational Knowledge’’: A Rational Bridge between Genetics and the Symptoms of Mental Illness
Arnsten, A. (2013)
Self-citation

Authors: Hains, A. B., & Arnsten, A. F. T.
Affiliations: Yale University (US)
ORCID: Arnsten, Amy F.T.
Venue: Learning & Memory
Publisher: Cold Spring Harbor Laboratory
Published: 2008-08
Volume: 15
Issue: 8
Pages: 551-564
ISSN: 1072-0502 (ISSN-L)
1549-5485
DOI: 10.1101/lm.921708
OpenAlex: W2137006544
Cited by: 127
References: 261
Citations by year: 2026: 4 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 11 · 2015: 6 · 2014: 9 · 2013: 10 · 2012: 10
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Learning & Memory (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (U54RR024350)
National Institute on Alcohol Abuse and Alcoholism (RL1AA017536)
National Institute of Mental Health (P50MH068789)
National Center for Research Resources (U54RR024350-01)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: prefrontal cortex, stress, mental illness, dopamine D1 receptor, cAMP signaling, DISC1, RGS4, diacylglycerol kinase, bipolar disorder, schizophrenia, genetic susceptibility, working memory, disinhibition, thought disorder, stress-induced cognitive impairment
MeSH terms: Animals, Mental Disorders, Humans, Stress, Physiological, Signal Transduction, Prefrontal Cortex

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Molecular mechanisms of stress-induced prefrontal cortical impairment: Implications for mental illness

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