Cited by 274RNA and protein synthesis mechanismsOrigins and Evolution of LifeEvolution and Genetic Dynamics

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On the Fundamental Nature and Evolution of the Genetic Code

Woese, C. R., Dugre, D. H., Dugre, S. A., Kondo, M., Saxinger, W. C.·1966·Cold Spring Harbor Symposia on Quantitative Biology

DOI 10.1101/sqb.1966.031.01.093

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Abstract

The present symposium defines clearly the current state of our knowledge of the genetic code. On one level we possess a high degree of comprehension of the code. And continuation of the present lines of research (based for the most part upon certain in vitro systems plus complementing in vivo studies) promises soon to complete our understanding of the code on this level. We now know, for example, essentially all of the codon assignments; we are making significant strides in elucidating the genetic sequences concerned with punctuation and modulation and with the (possibly) related phenomenon of relative codon usage; and we are beginning to understand the complex mechanisms involved in gene transcription and translation.

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Authors: Woese, C. R., Dugre, D. H., Dugre, S. A., Kondo, M., & Saxinger, W. C.
Affiliations: University of Illinois Urbana-Champaign (US)
Venue: Cold Spring Harbor Symposia on Quantitative Biology
Publisher: Cold Spring Harbor Laboratory
Published: 1966-01-01
Volume: 31
Issue: 0
Pages: 723-736
ISSN: 0091-7451 (ISSN-L)
1943-4456
DOI: 10.1101/sqb.1966.031.01.093
OpenAlex: W2027298209
Cited by: 274
References: 0
Citations by year: 2026: 7 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 12 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 8 · 2012: 5
Type: posted content
Language: en
Open access: closed
Locations: Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: genetic code, codon assignment, codon usage bias, gene transcription, translation (biology), in vitro translation system, genetic code evolution
MeSH terms: Amino Acids, Chemistry, Biological Evolution, Genetic Code, Models, Biological, Ribosomes, RNA, Transfer, Chemical Phenomena

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On the Fundamental Nature and Evolution of the Genetic Code

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