PreprintCited by 271Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchProteoglycans and glycosaminoglycans research

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Expression of Neural Proteoglycans Correlates with the Acquisition of Mature Neuronal Properties in the Mammalian Brain

Hockfield, S., Kalb, R.G., Zaremba, S., Fryer, H.·1990·Cold Spring Harbor Symposia on Quantitative Biology

DOI 10.1101/sqb.1990.055.01.049

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Abstract

The neurons in the mature mammalian central nervous system (CNS) are an enormously diverse group of cells. The acquisition of mature, differentiated neuronal properties takes place over an extended developmental period, through a number of different mechanisms. Some of the very last events in neuronal development occur late in the postnatal period, when the mature set of synapses between neurons and their targets is selected and the adult anatomical and physiological properties of neurons are acquired. Experiments in many different systems have shown that the mature set of synapses is selected from an initial set by selective stabilization of some synapses and elimination of others (for review, see Purves and Lichtman 1985). The process of synapse selection is governed, at least in part, by neuronal activity. Temporal matching of pre-and postsynaptic activity is thought to be critical in determining whether a synapse will be retained or lost. Environmental stimuli (such...

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Crossref · 10.1101/sqb.1990.055.01.049

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Items 101–200 of 267

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Kalb, R. G., & Hockfield, S. J. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90020-m · Cited by 63
Self-citation
Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome
Carstens, K. E., Lustberg, D. J., Shaughnessy, E. K., McCann, K. E., Alexander, G. M., & Dudek, S. M. (2021) · Journal of Clinical Investigation · doi:10.1172/jci137221 · Cited by 57
Update on Perineuronal Net Staining With Wisteria floribunda Agglutinin (WFA)
Härtig, W., Meinicke, A., Michalski, D., Schob, S., & Jäger, C. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.851988 · Cited by 60
Unique features of extracellular matrix in the mouse medial nucleus of trapezoid body – Implications for physiological functions
Blosa, M., Sonntag, M., Brückner, G., Jäger, C., Seeger, G., Matthews, R. T., Rübsamen, R., Arendt, T., & Morawski, M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.003 · Cited by 60
Normal Development of the Perineuronal Net in Humans; In Patients with and without Epilepsy
Rogers, S. L., Rankin-Gee, E., Risbud, R. M., Porter, B. E., & Marsh, E. D. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.039 · Cited by 63
“of particular subsets of neurons, including parvalbumin-positive interneurons and, to a lesser degree, pyramidal neurons (Hockfield et al. 1990; Bruckner et al. 1993; Celio and Blumcke 1994, Hartig et al. 1999, Giamanco and Matthews 2012).”
Background
Evidence for proteolytic cleavage of brevican by the ADAMTSs in the dentate gyrus after excitotoxic lesion of the mouse entorhinal cortex
Mayer, J., Hamel, M. G., & Gottschall, P. E. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-52 · Cited by 57
“Brevican and other lecticans are found in perineuronal nets and throughout the neuropil and are components of ECM aggregate complexes that are thought to stabilize synapses in neural networks and inhibit neurite outgrowth [13,14].”
Freeing the Brain from the Perineuronal Net
Fox, K. D., & Caterson, B. (2002) · Science · doi:10.1126/science.1079224 · Cited by 57
Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture
Wohl, S. G., Jorstad, N. L., Levine, E. M., & Reh, T. A. (2017) · Nature Communications · doi:10.1038/s41467-017-01624-y · Cited by 56
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Spijker, S., Koskinen, M.-K., & Riga, D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.015 · Cited by 55
“PNN formation is linked to restricted plasticity, as they act as a physical barrier that inhibits formation of novel synaptic contacts onto the surrounding cell, while providing structural support for the existing ones (Hockfield et al., 1990; Nikonenko et al., 2003; Sullivan et al., 2018).”
Brain Tissue-Derived Extracellular Vesicles in Alzheimer’s Disease Display Altered Key Protein Levels Including Cell Type-Specific Markers
Huang, Y., Driedonks, T. A. P., Cheng, L., Turchinovich, A., Rajapaksha, H., Arab, T., Powell, B. H., Pletniková, O., Redding‐Ochoa, J., Troncoso, J. C., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220322 · Cited by 58
Disruption of perineuronal nets increases the frequency of sharp wave ripple events
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Brevican isoforms associate with neural membranes
Seidenbecher, C. I., Smalla, K., Fischer, N., Gundelfinger, E. D., & Kreutz, M. R. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01183.x · Cited by 55
“It is well documented that ECM components are more tightly cross-linked and less soluble in the mature brain than at early postnatal stages (Hockfield et al. 1990; Rauch 1997; Yamaguchi 2000).”
Background
Altered production and proteolytic processing of brevican by transforming growth factor β in cultured astrocytes
Hamel, M. G., Mayer, J., & Gottschall, P. E. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03144.x · Cited by 54
“Since intact brevican may stabilize synaptic networks (Hockfield et al. 1990), and because cleavage of brevican may loosen aggregates of ECM in the brain and produce favorable conditions for morphological plasticity (Yamaguchi 2000; Yuan et al. 2002), it may be that TGFb stabilizes these networks…”
Background
Discordant localization of WFA reactivity and brevican/ADAMTS-derived fragment in rodent brain
Ajmo, J. M., Eakin, A. K., Hamel, M. G., & Gottschall, P. E. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-14 · Cited by 53
“It is localized perisynaptically, it inhibits neurite outgrowth [31] and it is thought to stabilize neural networks in the adult [13].”
Background
Histochemical differences between motoneurons supplying multiply and singly innervated extraocular muscle fibers
Eberhorn, A. C., Ardeleanu, P., Büttner‐Ennever, J. A., & Horn, A. K. E. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20715 · Cited by 52
“Furthermore, PVimmunoreactive neurons are often associated with perineuronal nets (Härtig et al., 1994; Horn et al., 2003), although the function of these nets is still unclear (e.g., Hockfield et al., 1990; Okamoto et al., 1994; Brückner et al., 1999).”
Background
SPARC, an extracellular matrix glycoprotein containing the follistatin module, is expressed by astrocytes in synaptic enriched regions of the adult brain
Mendis, D. B., Malaval, L., & Brown, I. R. (1995) · Brain Research · doi:10.1016/0006-8993(95)00101-u · Cited by 52
Elevated matrix metalloproteinase-9 and degradation of perineuronal nets in cerebrocortical multiple sclerosis plaques
Gray, E., Thomas, T. L., Betmouni, S., Scolding, N., & Love, S. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318183d003 · Cited by 51
Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure
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“Today, we know that the PN surrounds synapses on the cell body, proximal dendrites, and the axon hillock of certain neurons in a lattice-like structure, and is therefore uniquely positioned to influence synaptic development and stabilization (Hockfield et al., 1990).”
Background
Effects of Digesting Chondroitin Sulfate Proteoglycans on Plasticity in Cat Primary Visual Cortex
Vorobyov, V., Kwok, J. C. F., Fawcett, J. W., & Sengpiel, F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2283-12.2013 · Cited by 51
The neuronal extracellular matrix restricts distribution and internalization of aggregated Tau-protein
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Perineuronal nets show intrinsic patterns of extracellular matrix differentiation in organotypic slice cultures
Grosche, J., & Br�ckner, G. (2001) · Experimental Brain Research · doi:10.1007/s002210000617 · Cited by 55
BEHAB/brevican: a brain-specific lectican implicated in gliomas and glial cell motility
Gary, S. C., Kelly, G. M., & Hockfield, S. J. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80083-4 · Cited by 50
Self-citation
Saccadic omnipause and burst neurons in monkey and human are ensheathed by perineuronal nets but differ in their expression of calcium‐binding proteins
Horn, A. K. E., Brückner, G., Härtig, W., & Messoudi, A. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10495 · Cited by 49
“Suggested functions are the stabilization of synaptic contacts during development (Hockfield et al., 1990) or the protection of neurons against toxic agents, e.g., glutamate (Okamoto et al., 1994), or in degenerative diseases (Brückner et al., 1999).”
Background
Perineuronal and perisynaptic extracellular matrix in the human spinal cord
Jäger, C., Lendvai, D., Seeger, G., Brückner, G., Matthews, R. T., Arendt, T., Alpár, A., & Morawski, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.014 · Cited by 48
Perineuronal nets in the auditory system
Sonntag, M., Blosa, M., Schmidt, S., Rübsamen, R., & Morawski, M. (2015) · Hearing Research · doi:10.1016/j.heares.2014.12.012 · Cited by 50
Increased potassium, chloride, and taurine conductances in astrocytes during hypoosmotic swelling
Olson, J. E., & Li, G. (1997) · Glia · doi:10.1002/(sici)1098-1136(199707)20:3 · Cited by 46
Self-citation
Hyaluronan synthesis by developing cortical neurons in vitro
Fowke, T. M., Karunasinghe, R. N., Bai, J.-Z., Jordan, S., Gunn, A. J., & Dean, J. M. (2017) · Scientific Reports · doi:10.1038/srep44135 · Cited by 47
Versican in the Developing Brain: Lamina-Specific Expression in Interneuronal Subsets and Role in Presynaptic Maturation
Yamagata, M., & Sanes, J. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1976-05.2005 · Cited by 48
“These nets appear postnatally, around the time that synaptic connections stabilize, and they appear to participate in the stabilization process (Hockfield et al., 1990; Dityatev and Schachner, 2003).”
Background
Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex
Ueno, H., Fujii, K., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Aoki, S., Okamoto, M., Ishihara, T., & Takao, K. (2018) · IBRO Reports · doi:10.1016/j.ibror.2018.01.002 · Cited by 49
“Aggrecan expression in PNNs signals the end of the critcal period, and is dependent on sensory input (Sur et al., 1988; ockfield et al., 1990).”
Background
THE PROTEOGLYCAN DSD‐1‐PG OCCURS IN PERINEURONAL NETS AROUND PARVALBUMIN‐IMMUNOREACTIVE INTERNEURONS OF THE RAT CEREBRAL CORTEX
Wintergerst, E. S., Faissner, A., & Celio, M. R. (1996) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(96)00011-1 · Cited by 46
Sensory experience-dependent formation of perineuronal nets and expression of Cat-315 immunoreactive components in the mouse somatosensory cortex
Ueno, H., Suemitsu, S., Okamoto, M., Matsumoto, Y., & Ishihara, T. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.041 · Cited by 49
“Aggrecan has been implicated in the loss of plasticity (Sur et al., 1988; Hockfield et al., 1990), so aggrecan expression in WFA+ PNNs is expected to reduce synaptic plasticity in somatosensory cortex.”
Background
Hyperphosphorylated protein tau is restricted to neurons devoid of perineuronal nets in the cortex of aged bison⋆
Härtig, W. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00179-2 · Cited by 46
SC1, a brain extracellular matrix glycoprotein related to SPARC and follistatin, is expressed by rat cerebellar astrocytes following injury and during development
Mendis, D. B., Ivy, G. O., & Brown, I. R. (1996) · Brain Research · doi:10.1016/0006-8993(96)00440-4 · Cited by 45
Expression of the gene encoding the extracellular matrix glycoprotein SPARC in the developing and adult mouse brain
Mendis, D. B., & Brown, I. R. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90112-0 · Cited by 42
SC1, A SPARC-related glycoprotein, exhibits features of an ECM component in the developing and adult brain
Mendis, D. B., Shahin, S. M., Gurd, J. W., & Brown, I. R. (1996) · Brain Research · doi:10.1016/0006-8993(95)01472-1 · Cited by 42
Low expression of extracellular matrix components in rat brain stem regions containing modulatory aminergic neurons
Hobohm, C., Härtig, W., Brauer, K., & Brückner, G. (1998) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(98)00044-1 · Cited by 41
Activity-Dependent Plasticity and Gene Expression Modifications in the Adult CNS
Carulli, D., Foscarin, S., & Rossi, F. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00050 · Cited by 38
“The organization of CSPGs into perineuronal nets, which are specialized structures surrounding some neuronal types (Brauer et al., 1984; Hockfield et al., 1990; Pizzorusso et al., 2002; Carulli et al., 2006), is a key event in the control of CNS plasticity by the extracellular matrix (Gogolla et al.”
Background
Neurobiology of Schizophrenia Onset
Woo, T.-U. W. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_243 · Cited by 46
“However, recent studies in rodents have identified the maturation of intracortical inhibition subserved by the parvalbumin (PV)-containing inhibitory neurons and the formation of extracellular matrix (ECM) environment as two important mechanisms that regulate the time course of the critical period for developmental sy…”
Background
Abnormal post‐translational and extracellular processing of brevican in plaque‐bearing mice over‐expressing APPsw
Ajmo, J. M., Bailey, L. A., Howell, M. D., Cortez, L. K., Pennypacker, K. R., Mehta, H. N., Morgan, D., Gordon, M. N., & Gottschall, P. E. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06647.x · Cited by 41
“The presence of brevican in the matrix affects neurite outgrowth and stabilizes synapses (Hockfield et al. 1990; Bandtlow and Zimmermann 2000; Yamaguchi 2000).”
Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection
Cheng, C.-H., Lin, C.-T., Lee, M.-J., Tsai, M., Huang, W.-H., Huang, M.-C., Lin, Y.-L., Chen, C.-J., Huang, W., & Cheng, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138705 · Cited by 43
“In adults, these molecules play a role in stabilizing neuronal structures and synaptic connections and restricting neuroplasticity [13, 14].”
Background
UP‐REGULATION OF A KERATAN SULFATE PROTEOGLYCAN FOLLOWING CORTICAL INJURY IN NEONATAL RATS
Geisert, E. E., Bidanset, D. J., Mar, N. D., & Robson, J. A. (1996) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(96)00012-3 · Cited by 39
Loss of interneurons and disruption of perineuronal nets in the cerebral cortex following hypoxia-ischaemia in near-term fetal sheep
Fowke, T. M., Galinsky, R., Davidson, J. O., Wassink, G., Karunasinghe, R. N., Prasad, J. D., Bennet, L., Gunn, A. J., & Dean, J. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-36083-y · Cited by 39
Differential expression of several molecules of the extracellular matrix in functionally and developmentally distinct regions of rat spinal cord
Vitellaro‐Zuccarello, L., Bosisio, P., Mazzetti, S., Monti, C., & Biasi, S. D. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0289-y · Cited by 40
“Other studies, however, have implicated PNNs in the stabilization of synaptic contacts and in the limitation of neuroplasticity (Kalb and Hockfield 1988, 1990, 1992, 1994; Hockfield et al. 1990; Pizzorusso et al. 2002).”
BackgroundResult
Activity-dependent structural changes during neuronal development
Hockfield, S. J., & Kalb, R. G. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90040-6 · Cited by 38
Self-citation
Extracellular matrix and synapse formation
Yang, L., Wei, M., Xing, B., & Zhang, C. (2022) · Bioscience Reports · doi:10.1042/bsr20212411 · Cited by 42
(Re)building the nervous system: A review of neuron–glia interactions from development to disease
Demmings, M. D., Chagas, L. D. S., Traetta, M. E., Rodrigues, R. S., Acutain, M. F., Barykin, E. P., Datusalia, A. K., German‐Castelan, L., Mattera, V. S., Mazengenya, P., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16258 · Cited by 44
“They participate in the stabilization of synapses and connections and play an important role in neural plasticity (Hockfield et al., 1990 ; Pizzorusso et al., 2006 ).”
Cortical development and neuroplasticity in Auditory Neuropathy Spectrum Disorder
Sharma, A., & Cardon, G. J. (2015) · Hearing Research · doi:10.1016/j.heares.2015.06.001 · Cited by 41
“In contrast, studies done in subjects who had been reared in constant darkness provided evidence of delayed sensitive period closure and concomitant decreased levels of CSPGs (Hockfield et al., 1990).”
ResultInfluential
Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets
Sonntag, M., Blosa, M., Schmidt, S., Reimann, K., Blum, K., Eckrich, T., Seeger, G., Hecker, D., Schick, B., Arendt, T., et al. (2018) · BMC Biology · doi:10.1186/s12915-018-0566-8 · Cited by 40
Proteins and Transcriptional Dysregulation of the Brain Extracellular Matrix in Parkinson’s Disease: A Systematic Review
Rike, W. A., & Stern, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087435 · Cited by 43
“The PNNs are located between neurons and glia and act as a physical barrier that inhibits further synapse development [39].”
Background
The Development and Activity-Dependent Expression of Aggrecan in the Cat Visual Cortex
Kind, P. C., Sengpiel, F., Beaver, C. J., Crocker-Buque, A., Kelly, G. M., Matthews, R. T., & Mitchell, D. E. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs015 · Cited by 38
“This transition away from an environment permissive for plasticity and growth correlates well with the decline in sensitivity to MD (Hockfield et al. 1990).”
Background
The role of polysialic acid and other carbohydrate polymers in neural structural plasticity
Fryer, H. J. L., & Hockfield, S. J. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80016-x · Cited by 38
Self-citation
Weaving a Net of Neurobiological Mechanisms in Schizophrenia and Unraveling the Underlying Pathophysiology
Bitanihirwe, B. K. Y., Mauney, S. A., & Woo, T.-U. W. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.03.1047 · Cited by 40
Enzymatic Degradation of Cortical Perineuronal Nets Reverses GABAergic Interneuron Maturation
Willis, A., Pratt, J. A., & MORRIS, B. J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02772-z · Cited by 38
“Incidentally, this ‘tightening’ of PNNs coincides with the closure of the critical period of cortical plasticity [23].”
Background
Two populations of luteinizing hormone-releasing hormone neurons in the forebrain of the rhesus macaque during embryonic development
Quanbeck, C., Sherwood, N. M., Millar, R. P., & Terasawa, E. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970414)380:3 · Cited by 120
Self-citation
Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex
Virgintino, D., Perissinotto, D., Girolamo, F., Mucignat, M. T., Montanini, L., Errede, M., Kaneiwa, T., Yamada, S., Sugahara, K., Roncali, L., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00694.x · Cited by 39
“The use of antibodies Cat-301, Cat-315 and Cat-316, raised against feline chondroitin sulphate PGs and recognizing PGs of variable sizes compatible with those of neurocan and brevican, has provided some insights into the composition of PNNs in different areas of the CNS in a variety of species [17, 33, 43, 64], and si…”
Result
The role of extracellular matrix in spinal cord development
Wiese, S., & Faissner, A. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.05.018 · Cited by 36
“The accumulative sugar side chain additions can be visualized as perineural nets (PNN) by using wisteria floribunda agglutinin (WGA), or specific antibodies to CSPG core proteins or chondroitinsulfate carbohydrates (Bradbury et al., 2002; Celio et al., 1998; Geissler et al., 2013; Hockfield et al., 1990; Kwok et al.,…”
Guiding Axons in the Central Nervous System: A Tissue Engineering Approach
Norman, L. L., Stroka, K. M., & Aranda‐Espinoza, H. (2009) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2009.0114 · Cited by 36
Neonatal conductive hearing loss disrupts the development of the Cat-315 epitope on perineuronal nets in the rat superior olivary complex
Myers, A. K., Ray, J., & Kulesza, R. J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.05.024 · Cited by 34
Perineuronal Nets Characterized by Vital Labelling, Confocal and Electron Microscopy in Organotypic Slice Cultures of Rat Parietal Cortex and Hippocampus
Brückner, G., Kacza, J., & Grosche, J. (2004) · Journal of Molecular Histology · doi:10.1023/b:hijo.0000023374.22298.50 · Cited by 33
“…formation of PNs and the perisynaptic accumulation of the matrix compartments suggest an involvement in termination of the period of synaptogenesis (Hockfield et al. 1990), PNs may also support the activity of the ensheathed neurons and that of the presynaptic parts of afferent axons after…”
BackgroundInfluential
A Sulfated Glycosaminoglycan Linkage Region Is a Novel Type of Human Natural Killer-1 (HNK-1) Epitope Expressed on Aggrecan in Perineuronal Nets
Yabuno, K., Morise, J., Kizuka, Y., Hashii, N., Kawasaki, N., Takahashi, S., Miyata, S., Izumikawa, T., Kitagawa, H., Takematsu, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144560 · Cited by 36
“Previous reports demonstrated that cats reared in the dark with less sensory input showed delay in both the closure of the critical period and the emergence of PNNs in their brains [19, 20].”
Background
The protein tyrosine phosphatase RPTPζ/phosphacan is critical for perineuronal net structure
Eill, G. J., Sinha, A., Morawski, M., Viapiano, M. S., & Matthews, R. T. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010830 · Cited by 32
“Early work noted that expression of PNNs in primary sensory cortices, such as visual and somatosensory cortex, is activity dependent and that the timing of their appearance is consistent with closure of developmental critical periods such as the critical period for ocular dominance plasticity (11, 12).”
Background
The protein tyrosine phosphatase RPTPζ/phosphacan is critical for perineuronal net structure
Eill, G. J., Sinha, A., Morawski, M., Viapiano, M. S., & Matthews, R. T. (2020) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)49907-8 · Cited by 32
Regulation of Synaptic Extracellular Matrix Composition Is Critical for Proper Synapse Morphology
Kurshan, P. T., Phan, A., Wang, G. J., Crane, M. M., Lu, H., & Shen, K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1183-14.2014 · Cited by 30
“that are marked by a high degree of neuronal outgrowth and synaptic refinement (Sur et al., 1988; Hockfield et al., 1990).”
Destruction of extracellular matrix proteoglycans is pervasive in simian retroviral neuroinfection
Medina‐Flores, R., Wang, G., Bissel, S. J., Murphey‐Corb, M., & Wiley, C. A. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.04.011 · Cited by 31
“Modification of CNS matrix components by in vivo digestion or genetic manipulation leads to discernible electrophysiological alterations (Brakebusch et al., 2002; Bukalo et al., 2001; Pizzorusso et al., 2002).”
BackgroundInfluential
Perineuronal nets and GABAergic cells in the inferior colliculus of guinea pigs
Foster, N. L., Mellott, J. G., & Schofield, B. R. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2013.00053 · Cited by 30
GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain
Narentuya, Takeda‐Uchimura, Y., Foyez, T., Zhang, Z., Akama, T. O., Yagi, H., Kato, K., Komatsu, Y., Kadomatsu, K., & Uchimura, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-40901-2 · Cited by 29
Chondroitin Sulfate Proteoglycans in the Nervous System
Yamaguchi, Y. (2000) · CRC Press eBooks · doi:10.1201/9780203909720.ch15 · Cited by 30
Transcriptional maturation of the mouse auditory forebrain
Hackett, T. A., Guo, Y. P., Clause, A. R., Hackett, N., Garbett, K. A., Zhang, P., Polley, D. B., & Mirnics, K. (2015) · BMC Genomics · doi:10.1186/s12864-015-1709-8 · Cited by 30
“In studies of visual or somatosensory cortex, Acan is upregulated during development and involved in the regulation of critical periods [79, 80].”
Background
The effect of hypoxic–ischemic brain injury in perinatal rats on the abundance and proteolysis of brevican and NG2
Aya-ay, J., Mayer, J., Eakin, A. K., Muffly, B. G., Anello, M., Sandy, J. D., & Gottschall, P. E. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.11.021 · Cited by 29
Cortical perineuronal nets in the gray short-tailed opossum ( Monodelphis domestica ): a distribution pattern contrasting with that shown in placental mammals
Brückner, G., Härtig, W., Seeger, J., Rübsamen, R., Reimer, K., & Brauer, K. (1998) · Anatomy and Embryology · doi:10.1007/s004290050135 · Cited by 29
Molecular mechanisms of experience‐dependent maturation in cortical GABA ergic inhibition
Begum, M., & Sng, J. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14103 · Cited by 27
“Not surprisingly, if one were to reduce or remove activity by deprivation paradigms, such as dark-rearing (Hockfield et al. 1990) or monocular deprivation (Sur et al.”
Background
Aggrecan-based extracellular matrix shows unique cortical features and conserved subcortical principles of mammalian brain organization in the Madagascan lesser hedgehog tenrec (Echinops telfairi Martin, 1838)
Morawski, M., Brückner, G., Jäger, C., Seeger, G., Künzle, H., & Arendt, T. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.018 · Cited by 28
Retinal ganglion cell survival in vitro maintained by a chondroitin sulfate proteoglycan from the superior colliculus carrying the HNK‐1 epitope
Nichol, K. A., Everett, A. W., Schulz, M. W., & Bennett, M. R. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490370509 · Cited by 28
BDNF and JNK Signaling Modulate Cortical Interneuron and Perineuronal Net Development: Implications for Schizophrenia-Linked 16p11.2 Duplication Syndrome
Willis, A., Pratt, J. A., & MORRIS, B. J. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa139 · Cited by 32
Distribution of N-Acetylgalactosamine-Positive Perineuronal Nets in the Macaque Brain: Anatomy and Implications
Mueller, A. L., Davis, A., Sovich, S., Carlson, S. S., & Robinson, F. R. (2016) · Neural Plasticity · doi:10.1155/2016/6021428 · Cited by 29
“PNNs finish forming at approximately the same time that critical periods end and synaptic connections mature [1, 15].”
Differentiation/regeneration of oligodendrocytes entails the assembly of a cell‐associated matrix
Szuchet, S., Watanabe, K., & Yamaguchi, Y. (2000) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00034-4 · Cited by 27
Chondroitin sulfate proteoglycan-based extracellular matrix in chicken (Gallus domesticus) brain
Morawski, M., Alpár, A., Brückner, G., Fiedler, A., Jäger, C., Gáti, G., Stieler, J., & Arendt, T. (2009) · Brain Research · doi:10.1016/j.brainres.2009.02.046 · Cited by 27
Perineuronal net, CSPG receptor and their regulation of neural plasticity.
Miao, Q., Ye, Q., & Zhang, X.-H. (2014) · PubMed · Cited by 27
Projection of non-cholinergic basal forebrain neurons ensheathed with perineuronal nets to rat mesocortex
Brückner, G., Schütz, A., Härtig, W., Brauer, K., Paulke, B., & Bigl, V. (1994) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(94)90032-9 · Cited by 27
The extracellular matrix of cerebral gray matter: Golgi's pericellular net and nissl's nervösen Grau revisited
Bignami, A., Asher, R., Perides, G., & Rahemtulla, F. G. (1992) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(92)90018-u · Cited by 27
Sugar glues for broken neurons
Swarup, V. P., Mencio, C. P., Hlady, V., & Kuberan, B. (2013) · BioMolecular Concepts · doi:10.1515/bmc-2012-0042 · Cited by 27
Modest alterations in patterns of motor neuron dendrite morphology in the Fmr1 knockout mouse model for fragile X
Thomas, C. C., Combe, C. L., Dyar, K. A., & Inglis, F. M. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.06.003 · Cited by 27
“…a function of the difficulty in fixation of immature tissues, due to the relatively low abundance of surface proteins within the spinal cord at this age (Hockfield et al., 1990), leading to diffuse labeling with DiI; and smaller numbers of easily identifiable neurons within these tissue samples.”
Distribution and development of molecularly distinct perineuronal nets in visual thalamus
Sabbagh, U., Monavarfeshani, A., Su, K., Zabet‐Moghaddam, M., Cole, J., Carnival, E., Su, J., Mirzaei, M., Gupta, V., Salekdeh, G. H., et al. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14614 · Cited by 26
“There have been conflicting data concerning PNNs in the mammalian visual thalamus; studies in cat identified the presence of Aggrecan-rich PNNs whereas human LGN appears to lack of well-defined PNNs and, instead, contains Aggrecan-rich perisynaptic axonal coats (Sur et al. 1988; Hockfield et al. 1990; Kind et al. 1995…”
BackgroundInfluential
Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex
Pintér, A., Hevesi, Z., Zahola, P., Alpár, A., & Hanics, J. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109710 · Cited by 28
Repair in the central nervous system
FitzGerald, J. J., & Fawcett, J. W. (2007) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.89b11.19651 · Cited by 26
Stem cells isolated from adult rat muscle differentiate across all three dermal lineages
Schultz, S. S., Abraham, S., & Lucas, P. A. (2006) · Wound Repair and Regeneration · doi:10.1111/j.1743-6109.2006.00114.x · Cited by 25
Morphology of local axon collaterals of electrophysiologically characterised neurons in the rat medial septal/ diagonal band complex
Henderson, Z., Morris, N. P., Grimwood, P., Fiddler, G., Yang, H., & Appenteng, K. (2001) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010212)430:3 · Cited by 35
Perineuronal nets increase inhibitory GABAergic currents during the critical period in rats.
Liu (2013) · PubMed · doi:10.3980/j.issn.2222-3959.2013.02.02 · Cited by 23
Reorganization of Synaptic Connections and Perineuronal Nets in the Deep Cerebellar Nuclei of Purkinje Cell Degeneration Mutant Mice
Blosa, M., Bursch, C., Weigel, S., Holzer, M., Jäger, C., Janke, C., Matthews, R. T., Arendt, T., & Morawski, M. (2015) · Neural Plasticity · doi:10.1155/2016/2828536 · Cited by 27
β-amyloid increases neurocan expression through regulating Sox9 in astrocytes: A potential relationship between Sox9 and chondroitin sulfate proteoglycans in Alzheimer's disease
Han, Y., Zhu, X., Xie, J., Zhao, Y., & Liu, X. (2016) · Brain Research · doi:10.1016/j.brainres.2016.06.010 · Cited by 23
Glycosaminoglycans of the Porcine Central Nervous System
Liu, Z., Masuko, S., Solakyildirim, K., Pu, D., Linhardt, R. J., & Zhang, F. (2010) · Biochemistry · doi:10.1021/bi101305b · Cited by 24
“Chondroitin sulfate proteoglycans (CSPGs), known to be diffusely present in the CNS matrix and the condensed matrix of perineuronal nets (PNNs) (2), are involved in the regulation of neuronal plasticity (3, 4), in neuroprotection (5, 6), and in support of ion homeostasis around highly active neurons (7-9).”
Background
Morphological properties of intracellularly labeled layer I neurons in rat neocortex
Zhou, F.-M., & Hablitz, J. J. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961209)376:2 · Cited by 79
Protein–protein interactions between tenascin-R and RPTPζ/phosphacan are critical to maintain the architecture of perineuronal nets
Sinha, A., Kawakami, J., Cole, K. S., Ladutska, A., Nguyen, M. Y., Zalmai, M. S., Holder, B. L., Broerman, V. M., Matthews, R. T., & Bouyain, S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104952 · Cited by 24
“The abbreviations used are: ACAN, aggrecan; BLI, biolayer interferometry; CA, carbonic anhydrase-like; cDNA, complementary DNA; CNS, central nervous system; DIV, day in vitro; E, embryonic day; ECM, extracellular matrix; EGF, epidermal growth factor-like; FBS, fetal bovine serum; Fg, fibrinogen-like; FN, fibronectin t…”
BackgroundInfluential
Integrity of neural extracellular matrix is required for microglia‐mediated synaptic remodeling
Cangalaya, C., Sun, W., Stoyanov, S., Dunay, I. R., & Dityatev, A. E. (2024) · Glia · doi:10.1002/glia.24588 · Cited by 27
“Micro-glial cells may modulate both condensed (perineuronal nets or PNNs) and diffuse (perisynaptic) forms of neural ECM (Deepa et al., 2006; Dityatev et al., 2010; Fawcett et al., 2019; Galtrey et al., 2007; Hockfield et al., 1990; Schwartz & Domowicz, 2018).”
Sexually dimorphic perineuronal net expression in the songbird
Meyer, C., Boroda, E., & Nick, T. A. (2013) · Basal Ganglia · doi:10.1016/j.baga.2013.10.002 · Cited by 22
Environmental Enrichment From Birth Impacts Parvalbumin Expressing Cells and Wisteria Floribunda Agglutinin Labelled Peri-Neuronal Nets Within the Developing Murine Striatum
O’Connor, A. M., Burton, T. J., Mansuri, H., Hand, G. R., Leamey, C. A., & Sawatari, A. (2019) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2019.00090 · Cited by 21
“, 1999), while the maintenance of a mature, relatively stable circuit depends on the formation of perineuronal nets (PNNs), extracellular matrix structures consisting of chondroitin sulfate proteoglycans that encapsulate PV cells (Hockfield et al., 1990; Hartig et al., 1994; Bruckner et al., 2000; McRae et al., 2007).”
Background
Distribution of perineuronal nets in the human superior olivary complex
Schmidt, E., Wolski, T. P., & Kulesza, R. J. (2010) · Hearing Research · doi:10.1016/j.heares.2010.03.077 · Cited by 21
Chondroitin sulfate proteoglycans in the rat thalamus: expression during postnatal development and correlation with calcium-binding proteins in adults
Vitellaro‐Zuccarello, L., Meroni, A., Amadeo, A., & Biasi, S. D. (2001) · Cell and Tissue Research · doi:10.1007/s004410100425 · Cited by 21
“…Flaccus et al. 1991; Rauch et al. 1991; Oohira et al. 1994; Maeda et al. 1995; Miller et al. 1995; FernaudEspinosa et al. 1996; Köppe et al. 1997; Hoffman-Kim et al. 1998) have shown that, during brain development, a diffuse and relatively abundant extracellular matrix contains complex…”
Background
Acute Murine H5N1 Influenza A Encephalitis
Bissel, S. J., Giles, B. M., Wang, G., Olevian, D. C., Ross, T. M., & Wiley, C. A. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00514.x · Cited by 18
“As PNN modulate synaptic plasticity in mature neurons (23) and protect fast-spiking neurons from excitotoxic damage (20, 31), disruption of the ECM during influenza encephalitis could contribute to neurodegeneration by loss of trophic interactions, exacerbating abnormal protein accumulation, excitotoxicity or oxidativ…”

Authors: Hockfield, S., Kalb, R. G., Zaremba, S., & Fryer, H.
Affiliations: Yale University (US)
ORCID: Kalb, R.G.
Zaremba, S.
Fryer, H.
Venue: Cold Spring Harbor Symposia on Quantitative Biology
Publisher: Cold Spring Harbor Laboratory
Published: 1990-01-01
Volume: 55
Issue: 0
Pages: 505-514
ISSN: 0091-7451 (ISSN-L)
1943-4456
DOI: 10.1101/sqb.1990.055.01.049
OpenAlex: W2325060126
Cited by: 271
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 10 · 2019: 4 · 2018: 9 · 2017: 7 · 2016: 5 · 2015: 12 · 2014: 13 · 2013: 12 · 2012: 11
Type: posted content
Language: en
Open access: closed
Locations: Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k08ns001247-04, 5f32ey005855-02)
National Eye Institute (EY05855, EY 06511)
National Institute of Neurological Disorders and Stroke (NS-01247)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords: neuronal maturation, postnatal brain development, synaptic pruning, synaptic stabilization, central nervous system development
MeSH terms: Animals, Antibodies, Monoclonal, Brain, Cats, Cell Differentiation, Extracellular Matrix, Motor Neurons, Neurons, Chondroitin Sulfate Proteoglycans, Proteoglycans, Spinal Cord, Visual Cortex

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Expression of Neural Proteoglycans Correlates with the Acquisition of Mature Neuronal Properties in the Mammalian Brain

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