Rethinking the regulation of cellular metabolism
Open accessAbstract
Most biologists working today have not considered the problem of how signal transduction events, which commit cells to energetically demanding processes such as growth and division, are connected to cellular metabolism. The primary reason for this is that we have believed for the last 30 or more years that the metabolism of cells is a homeostatic, self-regulating process that does not depend on any extracellular input. The traditional view is that a mammalian cell decides to take up nutrients whenever its bioenergetic and synthetic reserves are depleted. However, a considerable body of evidence now exists that challenges the notion that the nutrient uptake and metabolism of metazoan cells are cell-autonomous.
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As glucose uptake and usage are under growth factor control, this observation raises the possibility that a basal level of TCA cycle oxidation in cells can persist independent of exogenous growth factor stimulation.
“As glucose uptake and usage are under growth factor control (58, 59, 60), this observation raises the possibility that a basal level of TCA cycle oxidation in cells can persist independent of exogenous growth factor stimulation.”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [59]
Normally metazoan cells do not import nutrients constitutively; nutrient uptake is strictly regulated by growth factor signaling.
“Normally, despite being surrounded by nutrient-rich plasma and the extracellular fluid, metazoan cells do not import nutrients in a constitutive manner. On the contrary, nutrient uptake is strictly regulated by growth factor signaling”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Thompson, 2011
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- Authors
- Thompson, C. B.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Thompson, C. B.
- ORCID
- Thompson, C. B.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-01-01
- Volume
- 76
- Issue
- 0
- Pages
- 23-29
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2126100522
- Cited by
- 66
- References
- 18
- Citations by year
- 2025: 6 · 2024: 5 · 2023: 1 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- signal transduction, nutrient uptake, metabolic homeostasis, cell growth and division, metazoan cells
- MeSH terms
- Animals, Cells, Extracellular Space, Glycolysis, Humans, Neoplasms, Signal Transduction, Apoptosis
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