Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766 · see citing works

The emerging hallmarks of cancer metabolism

Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926 · see citing works

Cancer genes and the pathways they control

Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,245 · see citing works

STATs: transcriptional control and biological impact

Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201 · see citing works

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · see citing works

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124 · see citing works

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001 · see citing works

Double-Strand Break End Resection and Repair Pathway Choice

Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,482 · see citing works

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

Ward, I. M., & Chen, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100569200 · Cited by 1,150 · see citing works

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

Mao, Z., Bozzella, M. J., Seluanov, A., & Gorbunova, V. A. (2008) · Cell Cycle · doi:10.4161/cc.7.18.6679 · Cited by 695 · see citing works

Cancer Stem Cells in Radiation Resistance

Rich, J. N. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0895 · Cited by 497 · see citing works

Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage

Deriano, L., & Roth, D. B. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155540 · Cited by 448 · see citing works

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

Jeong, S. M., Xiao, C., Finley, L. W. S., Lahusen, T., Souza, A. L., Pierce, K., Li, Y.-H., Wang, X., Laurent, G., German, N. J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.024 · Cited by 445 · see citing works

ATM activates the pentose phosphate pathway promoting anti‐oxidant defence and DNA repair

Cosentino, C., Grieco, D., & Costanzo, V. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.330 · Cited by 436 · see citing works

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons

Wang, W., Pan, L., Su, S. C., Quinn, E. J., Sasaki, M., Jimenez, J., Mackenzie, I. R., Huang, E. J., & Tsai, L. (2013) · Nature Neuroscience · doi:10.1038/nn.3514 · Cited by 433 · see citing works

Radiation Resistance of Cancer Stem Cells: The 4 R's of Radiobiology Revisited

Pajonk, F., Vlashi, E., & McBride, W. H. (2010) · Stem Cells · doi:10.1002/stem.318 · Cited by 393 · see citing works

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice

Zhu, J., Petersen, S., Tessarollo, L., & Nussenzweig, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00019-7 · Cited by 374 · see citing works

Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation.

Turner, B. C., Haffty, B. G., Narayanan, L., Yuan, J., Havre, P. A., Gumbs, A. A., Kaplan, L., Burgaud, J., Carter, D., Baserga, R., et al. (1997) · PubMed · Cited by 342 · see citing works

DNA Repair in Mammalian Cells

Pardo, B., Gómez‐González, B., & Aguilera, A. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8740-3 · Cited by 323 · see citing works

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

Venneti, S., Dunphy, M. P., Zhang, H., Pitter, K. L., Zanzonico, P., Campos, C., Carlin, S., Rocca, G. L., Lyashchenko, S. K., Plöessl, K., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa1009 · Cited by 314 · see citing works

BCR/ABL Regulates Mammalian RecA Homologs, Resulting in Drug Resistance

Słupianek, A., Schmütte, C., Tombline, G., Nieborowska-Skorska, M., Hoser, G., Nowicki, M. O., Pierce, A. J., Fishel, R. A., & Skórski, T. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00357-4 · Cited by 313 · see citing works

Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation

Bott, A. J., Peng, I., Fan, Y., Faubert, B., Zhao, L. H., Li, J., Neidler, S., Sun, Y., Jaber, N. L., Krokowski, D., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.025 · Cited by 259 · see citing works

DNA Double-Strand Break Repair Inhibitors as Cancer Therapeutics

Srivastava, M., & Raghavan, S. C. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.11.013 · Cited by 222 · see citing works

DNA Repair and Resistance of Gliomas to Chemotherapy and Radiotherapy

Fròsina, G. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0030 · Cited by 180 · see citing works

Radiation–Induced Signaling Results in Mitochondrial Impairment in Mouse Heart at 4 Weeks after Exposure to X-Rays

Barjaktarović, Ž., Schmaltz, D., Shyla, A., Azimzadeh, O., Schulz, S., Haagen, J., Dörr, W., Sarioglu, H., Schäfer, A., Atkinson, M. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027811 · Cited by 163 · see citing works

Radiation resistance: Cancer stem cells (CSCs) and their enigmatic pro-survival signaling

Skvortsova, I., Debbage, P. L., Kumar, V., & Skvortsov, S. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.09.009 · Cited by 149 · see citing works

How does DNA break during chromosomal translocations?

Nambiar, M., & Raghavan, S. C. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr223 · Cited by 146 · see citing works

ATR and H2AX cooperate in maintaining genome stability under replication stress

Chanoux, R. A., Yin, B., Urtishak, K. A., Asare, A., Bassing, C. H., & Brown, E. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806739200 · Cited by 130 · see citing works

Characterisation of the promoter region of the human DNA-repair gene Rad51.

Hasselbach, L. A., Haase, S., Fischer, D., Kolberg, H., & Stürzbecher, H. W. (2005) · PubMed · Cited by 115 · see citing works

Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy.

Liang, K., Jin, W., Knuefermann, C., Schmidt, M., Mills, G. B., Ang, K. K., Milas, L., & Fan, Z. (2003) · PubMed · Cited by 111 · see citing works

Effect of epidermal growth factor on the growth and radiation sensitivity of human breast cancer cells in vitro

Wollman, R. M., Yahalom, J., Mary, R. R., Pinto, J. T., & FUKS, Z. Y. (1994) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(94)90523-1 · Cited by 100 · see citing works

Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair

Byrne, R. T., Klingele, A. J., Cabot, E. L., Schackwitz, W., Martin, J. A., Martin, J., Wang, Z., Wood, E. A., Pennacchio, C., Pennacchio, L. A., et al. (2014) · eLife · doi:10.7554/elife.01322 · Cited by 92 · see citing works

Identification of Respiratory Complexes I and III as Mitochondrial Sites of Damage Following Exposure to Ionizing Radiation and Nitric Oxide

Pearce, L. L., Epperly, M. W., Greenberger, J. S., Pitt, B. R., & Peterson, J. (2001) · Nitric Oxide · doi:10.1006/niox.2001.0338 · Cited by 82 · see citing works

Rethinking the regulation of cellular metabolism

Thompson, C. B. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2012.76.010496 · Cited by 66 · see citing works

Local failure patterns for patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy

Li, J.-X., Huang, S.-M., Jiang, X.-H., Ouyang, B., Han, F., Liu, S., Wen, B., & Lu, T. (2014) · Radiation Oncology · doi:10.1186/1748-717x-9-87 · Cited by 64 · see citing works

Patterns of local-regional failure after primary intensity modulated radiotherapy for nasopharyngeal carcinoma

Kong, F., Ying, H., Du, C., Huang, S., Zhou, J., Chen, J., Sun, L., Chen, X., & Hu, C. (2014) · Radiation Oncology · doi:10.1186/1748-717x-9-60 · Cited by 59 · see citing works

STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair

Maranto, C., Udhane, V., Hoang, D. T., Gu, L., Alexeev, V. Y., Malas, K. M., Cardenas, K., Brody, J. R., Rodeck, U., Bergom, C. R., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2768 · Cited by 57 · see citing works

Prognostic significance of glutamine synthetase expression in unifocal advanced hepatocellular carcinoma

Osada, T., Nagashima, I., Tsuno, N. H., Kitayama, J., & Nagawa, H. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80365-7 · Cited by 55 · see citing works

Recovery of Oxidative Phosphorylation in Rat Liver Mitochondria after Whole Body Irradiation

Hall, J. C., Goldstein, A. L., & Sonnenblick, B. P. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81271-6 · Cited by 34 · see citing works

Vascular endothelial growth factor independently predicts the efficacy of postoperative radiotherapy in node-negative breast cancer patients.

Manders, P., Sweep, F. C. G. J., Tjan‐Heijnen, V. C. G., Geurts-Moespot, A. J., van Tienoven, D. T. H., Foekens, J. A., Span, P. N., Bussink, J., & Beex, L. V. A. M. (2003) · PubMed · Cited by 29 · see citing works

DNA Repair: Relationship to Drug and Radiation Resistance, Metastasis and Growth Factors

Harris, A. L. (1985) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008514551781 · Cited by 27 · see citing works

PIAS3 promotes homology-directed repair and distal non-homologous end joining

LIU, S., Fan, Z., Geng, Z., Zhang, H., Ye, Q., Jiao, S., & Xu, X. (2013) · Oncology Letters · doi:10.3892/ol.2013.1472 · Cited by 16 · see citing works

Mitochondrial genotypes and radiation-induced micronucleus formation in human osteosarcoma cells in vitro

Yoshida, K., Yamazaki, H., Ozeki, S., Inoue, T., Yoshioka, Y., Yoneda, M., Fujiwara, Y., & Inoue, T. (2001) · Oncology Reports · doi:10.3892/or.8.3.615 · Cited by 11 · see citing works

Glutamine reliance in cell metabolism

Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021 · see citing works

Molecular mechanisms of tumor resistance to radiotherapy

Wu, Y., Song, Y., Wang, R., & Wang, T. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01801-2 · Cited by 539 · see citing works

STAT proteins in cancer: orchestration of metabolism

Li, Y., Zhang, C., Martincuks, A., Herrmann, A., & Yu, H. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-022-00537-3 · Cited by 287 · see citing works

Mechanisms for Modulating Anoikis Resistance in Cancer and the Relevance of Metabolic Reprogramming

Adeshakin, F. O., Adeshakin, A. O., Afolabi, L. O., Yan, D., Zhang, G., & Wan, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.626577 · Cited by 271 · see citing works

Amino acid metabolism in tumor biology and therapy

Chen, J., Cui, L., Lu, S., & Xu, S. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06435-w · Cited by 268 · see citing works

The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies

Xu, D., Shao, F., Bian, X., Meng, Y., Liang, T., & Lu, Z. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.015 · Cited by 253 · see citing works

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Zhou, W., Yao, Y., Scott, A. J., Wilder-Romans, K., Dresser, J., Werner, C. K., Sun, H., Pratt, D. W., Sajjakulnukit, P., Zhao, S. G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17512-x · Cited by 244 · see citing works

Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy

Wu, H., Gong, Y., Ji, P., Xie, Y., Jiang, Y.-Z., & Liu, G. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01263-x · Cited by 192 · see citing works

Metabolic heterogeneity in cancer

Demicco, M., Liu, X., Leithner, K., & Fendt, S. (2024) · Nature Metabolism · doi:10.1038/s42255-023-00963-z · Cited by 183 · see citing works

Impact of cancer metabolism on therapy resistance – Clinical implications

Gonçalves, A. C., Richiardone, E., Jorge, J., Polónia, B. R. G., Xavier, C. P. R., Salaroglio, I. C., Riganti, C., Vasconcelos, M. H., Corbet, C., & Sarmento‐Ribeiro, A. B. (2021) · Drug Resistance Updates · doi:10.1016/j.drup.2021.100797 · Cited by 170 · see citing works

The adaptive transition of glioblastoma stem cells and its implications on treatments

Wang, Z., Zhang, H., Xu, S., Liu, Z., & Cheng, Q. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00491-w · Cited by 158 · see citing works

CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma

Tang, M., Dong, X., Xiao, L., Tan, Z., Luo, X., Yang, L., Li, W., Shi, F., Li, Y., Zhao, L., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04730-y · Cited by 135 · see citing works

Targeting the signaling in Epstein–Barr virus-associated diseases: mechanism, regulation, and clinical study

Cao, Y., Xie, L.-L., Shi, F., Tang, M., Li, Y.-S., Hu, J., Zhao, L., Zhao, L.-Q., Yu, X., Luo, X.-J., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00376-4 · Cited by 115 · see citing works

Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance

Wei, F., Wang, D., Wei, J., Tang, N., Tang, L. M., Xiong, F., Guo, C. J., Zhou, M., Li, X., Li, G., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03581-0 · Cited by 128 · see citing works

Insights into removal of sulfonamides in anaerobic activated sludge system: Mechanisms, degradation pathways and stress responses

Zhao, Q., Guo, W., Luo, H., Xing, C., Wang, H., Liu, B., Si, Q., Li, D., Sun, L., & Ren, N. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127248 · Cited by 104 · see citing works

New insights into molecules and pathways of cancer metabolism and therapeutic implications

Tang, Z., Xu, Z., Zhu, X. M., & Zhang, J. (2020) · 癌症：英文版 · doi:10.1002/cac2.12112 · Cited by 99 · see citing works

Interplay between Cellular Metabolism and the DNA Damage Response in Cancer

Moretton, A., & Loizou, J. I. (2020) · Cancers · doi:10.3390/cancers12082051 · Cited by 93 · see citing works

Cell Metabolism and DNA Repair Pathways: Implications for Cancer Therapy

Sobanski, T., Rose, M., Suraweera, A., O'Byrne, K. J., Richard, D. J., & Bolderson, E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.633305 · Cited by 86 · see citing works

Glutamine Synthetase as a Therapeutic Target for Cancer Treatment

Kim, G. W., Lee, D. H., Jeon, Y. H., Yoo, J. H., Kim, S. Y., Lee, S. W., Cho, H. Y., & Kwon, S. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041701 · Cited by 86 · see citing works

Integration of glucose and cardiolipin anabolism confers radiation resistance of HCC

Fang, Y., Zhan, Y., Xie, Y., Du, S., Chen, Y., Zeng, Z., Zhang, Y., Chen, K., Wang, Y., Li, L., et al. (2021) · Hepatology · doi:10.1002/hep.32177 · Cited by 86 · see citing works

m6A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis

He, J., Li, Z., Rong, Z., Gao, J., Mu, Y., Guan, Y., Ren, X.-X., Zi, Y.-Y., Liu, L.-Y. D., Fan, Q. W., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01166 · Cited by 85 · see citing works

Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1

Dai, W., Shen, J., Yan, J., Bott, A. J., Maimouni, S., Daguplo, H. Q., Wang, Y., Khayati, K., Guo, J. Y., Zhang, L., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci161408 · Cited by 70 · see citing works

On-Demand Generation of Peroxynitrite from an Integrated Two-Dimensional System for Enhanced Tumor Therapy

Liu, S., Li, W., Chen, H., Zhou, J., Dong, S., Zang, P., Tian, B., Ding, H., Gai, S., Yang, P., et al. (2022) · ACS Nano · doi:10.1021/acsnano.1c11422 · Cited by 69 · see citing works

Radiotherapy-induced metabolic hallmarks in the tumor microenvironment

Mittal, A., Nenwani, M., Sarangi, I., Achreja, A., Lawrence, T. S., & Nagrath, D. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.05.005 · Cited by 69 · see citing works

Linking Metabolic Reprogramming, Plasticity and Tumor Progression

Shuvalov, O., Daks, A., Fedorova, O., Petukhov, A., & Barlev, N. (2021) · Cancers · doi:10.3390/cancers13040762 · Cited by 63 · see citing works

Novel insight into metabolic reprogrammming in cancer radioresistance: A promising therapeutic target in radiotherapy

Yu, Y., Yu, J., Ge, S., Su, Y., & Fan, X. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.79928 · Cited by 56 · see citing works

DNA Damage Response and Metabolic Reprogramming in Health and Disease

Chatzidoukaki, O., Goulielmaki, E., Schumacher, B., & Garinis, G. A. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.06.018 · Cited by 54 · see citing works

Deciphering the Biological Effects of Radiotherapy in Cancer Cells

Zhou, L., Zheng, X., Ding, C., Zou, Z., Liang, Y., Zhou, Y., & Li, X. (2022) · Biomolecules · doi:10.3390/biom12091167 · Cited by 55 · see citing works

Reprogramming of glutamine metabolism via glutamine synthetase silencing induces cisplatin resistance in A2780 ovarian cancer cells

Guo, J., Satoh, K., Tabata, S., Mori, M., Tomita, M., & Soga, T. (2021) · BMC Cancer · doi:10.1186/s12885-021-07879-5 · Cited by 53 · see citing works

Localization, Gene Expression, and Functions of Glutamine Synthetase Isozymes in Wheat Grain (Triticum aestivum L.)

Wei, Y., Xiong, S., Zhang, Z., Meng, X., Wang, L., Zhang, X., Mei-qin, Y., Yu, H., Wang, X., & Ma, X. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.580405 · Cited by 47 · see citing works

Prostate-Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer

Sheehan, B., Neeb, A., Buroni, L., Paschalis, A., Riisnaes, R., Gürel, B., Gil, V., Miranda, S., Crespo, M., Guo, C. W., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-4531 · Cited by 51 · see citing works

Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma

Huang, H., Li, S., Tang, Q., & Zhu, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.680955 · Cited by 49 · see citing works

Linking Serine/Glycine Metabolism to Radiotherapy Resistance

Sánchez‐Castillo, A., Vooijs, M., & Kampen, K. R. (2021) · Cancers · doi:10.3390/cancers13061191 · Cited by 47 · see citing works

Tailoring Silica-Based Nanoscintillators for Peroxynitrite-Potentiated Nitrosative Stress in Postoperative Radiotherapy of Colon Cancer

Liu, S., Li, W., Zhang, Y., Zhou, J., Du, Y., Dong, S., Tian, B., Fang, L., Ding, H., Gai, S., et al. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c02472 · Cited by 47 · see citing works

Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence

Menegakis, A., Klompmaker, R., Vennin, C., Arbusà, A., Damen, M. P. F., van den Broek, B., Zips, D., van Rheenen, J., Krenning, L., & Medema, R. H. (2021) · Cells · doi:10.3390/cells10030610 · Cited by 44 · see citing works

Biomimetic Single‐Atom Nanozyme for Dual Starvation‐Enhanced Breast Cancer Immunotherapy

Zhang, N., Ping, W., Xiang, J., Chu, S., Li, D., Ning, S., Zhu, D., Zeng, W., & Xu, Q. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401362 · Cited by 42 · see citing works

Structural property, molecular regulation, and functional diversity of glutamine synthetase in higher plants: a data‐mining bioinformatics approach

Mondal, R., Kumar, A., & Chattopadhyay, S. K. (2021) · The Plant Journal · doi:10.1111/tpj.15536 · Cited by 41 · see citing works

DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy

Peng, Y., & Pei, H. (2021) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2000344 · Cited by 37 · see citing works

Metabolic response to radiation therapy in cancer

Read, G. H., Bailleul, J., Vlashi, E., & Kesarwala, A. H. (2021) · Molecular Carcinogenesis · doi:10.1002/mc.23379 · Cited by 35 · see citing works

Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment

Bao, L., Xu, T., Lu, X., Huang, P. C., Pan, Z., & Ge, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.773028 · Cited by 34 · see citing works

Epigenetic–Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer

Das, C., Adhikari, S., Bhattacharya, A., Chakraborty, S., Mondal, P., Yadav, S. S., Adhikary, S., Hunt, C. R., Yadav, K. K., Pandita, S., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-3015 · Cited by 36 · see citing works

The PIK3CA-E545K-SIRT4 signaling axis reduces radiosensitivity by promoting glutamine metabolism in cervical cancer

Jiang, W., Ouyang, X., Ji, Z., Shi, W., Wu, Y., Yao, Q., Wang, Y., Yang, W., Xiang, L., & Yang, H. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216064 · Cited by 34 · see citing works

Emerging strategies to target cancer metabolism and improve radiation therapy outcomes

Kery, M., & Papandreou, I. (2020) · British Journal of Radiology · doi:10.1259/bjr.20200067 · Cited by 29 · see citing works

Cancer-associated fibroblasts facilitate DNA damage repair by promoting the glycolysis in non-small cell lung cancer

Zhang, H., Zhang, K., Qiu, L., Yue, J., Jiang, H., Deng, Q., Zhou, R., Yin, Z., Ma, S., & Ke, Y. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166670 · Cited by 29 · see citing works

Metabolic reprogramming in nasopharyngeal carcinoma: Mechanisms and therapeutic opportunities

Liu, Q., Bode, A. M., Chen, X., & Luo, X. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189023 · Cited by 28 · see citing works

Apigenin increases radiosensitivity of glioma stem cells by attenuating HIF-1α-mediated glycolysis

Zhao, Y., Huang, H., Jia, C., Fan, K., Xie, T., Zhu, Z., & Xie, M.-L. (2021) · Medical Oncology · doi:10.1007/s12032-021-01586-8 · Cited by 28 · see citing works

Overcoming Radiation Resistance in Gliomas by Targeting Metabolism and DNA Repair Pathways

Meng, W., Palmer, J. D., Siedow, M. R., Haque, S. J., & Chakravarti, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042246 · Cited by 30 · see citing works

Tumor Metabolic Reprogramming and Ferroptosis: The Impact of Glucose, Protein, and Lipid Metabolism

Zhu, K., Cai, Y., Lan, L., & Luo, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413413 · Cited by 27 · see citing works

Purinergic receptors are a key bottleneck in tumor metabolic reprogramming: The prime suspect in cancer therapeutic resistance

Aria, H., Rezaei, M., Nazem, S., Daraei, A., Nikfar, G., Mansoori, B., Bahmanyar, M., Tavassoli, A., Vakil, M. K., & Mansoori, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.947885 · Cited by 26 · see citing works

Unrestricted molecular motions enable mild photothermy for recurrence-resistant FLASH antitumor radiotherapy

Shen, H., Wang, H., Mo, J., Zhang, J., Xu, C., Sun, F., Ou, X., Zhu, X., Du, L., Ju, H., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.03.024 · Cited by 26 · see citing works

NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway

Sun, X., Dong, M., Li, J., Sun, Y., Gao, Y., Wang, Y., Du, L., Liu, Y., Ji, K., He, N., et al. (2024) · Theranostics · doi:10.7150/thno.88899 · Cited by 25 · see citing works

Glutamine Metabolism Scoring Predicts Prognosis and Therapeutic Resistance in Hepatocellular Carcinoma

Ying, L., Cheng, M., Lü, Y., Tao, Q., Chen, X., Shen, B., Xiong, F., Hu, Z., Wang, D., & Li, X. (2021) · Pathology & Oncology Research · doi:10.3389/pore.2021.1610075 · Cited by 24 · see citing works

Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress

Marx, C., Sonnemann, J., Maddocks, O. D. K., Marx-Blümel, L., Beyer, M., Hoelzer, D., Thierbach, R., Maletzki, C., Linnebacher, M., Heinzel, T., et al. (2022) · Cancer & Metabolism · doi:10.1186/s40170-022-00286-9 · Cited by 23 · see citing works

Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer

Zhai, L., Yang, X., Cheng, Y., & Wang, J. (2023) · Cancer Medicine · doi:10.1002/cam4.6256 · Cited by 24 · see citing works

Glutamine-dependent signaling controls pluripotent stem cell fate

Lu, V., Roy, I. J., Torres, A., Joly, J. H., Ahsan, F. M., Graham, N. A., & Teitell, M. A. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.02.003 · Cited by 23 · see citing works

Identification of crucial genes of pyrimidine metabolism as biomarkers for gastric cancer prognosis

Wu, Z., Tan, J., Zhuang, Y., Zhong, M., Xiong, Y., Ma, J., Yang, Y., Gao, Z., Zhao, J., Ye, Z., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02385-x · Cited by 23 · see citing works

Glutamine Synthetase Contributes to the Regulation of Growth, Conidiation, Sclerotia Development, and Resistance to Oxidative Stress in the Fungus Aspergillus flavus

Wang, S., Lin, R., Tumukunde, E., Zeng, W., Bao, Q., Wang, S., & Wang, Y. (2022) · Toxins · doi:10.3390/toxins14120822 · Cited by 23 · see citing works

Cytoophidia coupling adipose architecture and metabolism

Liu, J., Zhang, Y., Zhou, Y., Wang, Q.-Q., Ding, K., Zhao, S., Lu, P., & Liu, J. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04567-w · Cited by 22 · see citing works

Molecular mechanisms of m6A modifications regulating tumor radioresistance

Shen, R., Jiang, Z., Wang, H., Zheng, Z., & Jiang, X. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01121-9 · Cited by 21 · see citing works

Oncogenic viral infection and amino acid metabolism in cancer progression: Molecular insights and clinical implications

Liu, N., Shi, F., Yang, L., Liao, W., & Cao, Y. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188724 · Cited by 21 · see citing works

Purine Metabolism and Pyrimidine Metabolism Alteration Is a Potential Mechanism of BDE-47-Induced Apoptosis in Marine Rotifer Brachionus plicatilis

Cao, S., Wang, J. E., You, X., Zhou, B., Wang, Y., & Zhou, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612726 · Cited by 21 · see citing works

Glutamine Metabolism and Prostate Cancer

Erb, H. H. H., Polishchuk, N., Stasyk, O. V., Kahya, U., Weigel, M. M., & Dubrovska, A. (2024) · Cancers · doi:10.3390/cancers16162871 · Cited by 23 · see citing works

Rab25-Mediated EGFR Recycling Causes Tumor Acquired Radioresistance

Zhang, L., Xie, B., Qiu, Y., Jing, D., Zhang, J., Duan, Y., Li, Z., Fan, M., He, J., Qiu, Y., et al. (2020) · iScience · doi:10.1016/j.isci.2020.100997 · Cited by 20 · see citing works

Glioblastomas: Hijacking Metabolism to Build a Flexible Shield for Therapy Resistance

Bailleul, J., & Vlashi, E. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0088 · Cited by 22 · see citing works

Recent advances in radiosensitivity determinants in melanoma

Krayem, M., Ghanem, G. E., & Gestel, D. V. (2022) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000818 · Cited by 19 · see citing works

Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance

Zarzuela, L., Durán, R. V., & Tomé, M. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13571 · Cited by 19 · see citing works

Zeolitic imidazolate framework-based nanoparticles for the cascade enhancement of cancer chemodynamic therapy by targeting glutamine metabolism

Jian, H., Zhang, Y., Wang, J., Chen, Z., & Wen, T. (2022) · Nanoscale · doi:10.1039/d2nr01736a · Cited by 18 · see citing works

A metabolic map and artificial intelligence-aided identification of nasopharyngeal carcinoma via a single-cell Raman platform

Xu, J., Chen, D., Wu, W., Ji, X., Dou, X., Gao, X., Li, J., Zhang, X., Huang, W. E., & Xiong, D. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02637-3 · Cited by 17 · see citing works

Spatiotemporal Heterogeneity of Tumor Glucose Metabolism Reprogramming: From Single-Cell Mechanisms to Precision Interventions

Chai, X., Tao, Q., & Li, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146901 · Cited by 18 · see citing works

PPDPF Promotes the Progression and acts as an Antiapoptotic Protein in Non-Small Cell Lung Cancer

Mu, Y., Li, Y., Jie, G., Guanxin, L., Zeng, Z., Cao, Z., Li, Z., Yingjie, N., Sun, L., Chen, T., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.65654 · Cited by 16 · see citing works

Glutamine as a Potential Noninvasive Biomarker for Human Embryo Selection

Miao, S., Feng, Y., Wang, X., Lian, K., Meng, F., Song, G., Yuan, J., Geng, C.-P., & Wu, X. (2022) · Reproductive Sciences · doi:10.1007/s43032-021-00812-y · Cited by 16 · see citing works

Metabolic and lipidomic characterization of radioresistant MDA-MB-231 human breast cancer cells to investigate potential therapeutic targets

Lee, H., To, N. B., Kim, M., Nguyen, Y. T.-K., Cho, S. K., & Choi, H. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114449 · Cited by 15 · see citing works

BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation

Yu, M., Zhao, Q., Li, J., Xu, F., Zhang, Z., Liu, Y., Dai, L., Zhang, B., Zhang, J., & Zhang, J. (2022) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2100985 · Cited by 15 · see citing works

Radiation induces M2 polarization of glioma-associated macrophages via upregulation of glutamine synthetases

Lu, Y., Zhou, C., Li, J., Liu, L., Liu, X., Shen, L., Lai, X., Gu, H., Zhang, Z., & Qian, J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114595 · Cited by 14 · see citing works

DNA damage-induced senescence is associated with metabolomic reprogramming in breast cancer cells

George, N., Joshi, M. B., & Satyamoorthy, K. (2023) · Biochimie · doi:10.1016/j.biochi.2023.09.021 · Cited by 14 · see citing works

Metabolic Adaptation and Cellular Stress Response As Targets for Cancer Therapy

Lee, C. J., & Yoon, H. (2023) · The World Journal of Men s Health · doi:10.5534/wjmh.230153 · Cited by 13 · see citing works

Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo

Patel, R., Cooper, D. E., Kadakia, K. T., Allen, A. E., Duan, L., Luo, L., Williams, N. T., Liu, X., Locasale, J. W., & Kirsch, D. G. (2024) · Communications Biology · doi:10.1038/s42003-024-06262-x · Cited by 13 · see citing works

RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma

Zhang, W., Yin, C., Qi, L., Liu, Z., Xu, R., Tu, C., & Li, Z. (2025) · Advanced Science · doi:10.1002/advs.202410937 · Cited by 13 · see citing works

Radioresistant Nasopharyngeal Carcinoma Cells Exhibited Decreased Cisplatin Sensitivity by Inducing SLC1A6 Expression

Hao, W., Wu, L., Cao, L., Yu, J., Li, N., Wang, J., Lin, X., & Chen, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.629264 · Cited by 13 · see citing works

In-depth analysis of the expression and functions of signal transducers and activators of transcription in human ovarian cancer

Gong, X., & Liu, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1054647 · Cited by 12 · see citing works

Effect of pH on antibiotic resistance genes removal and bacterial nucleotides metabolism function in the wastewater by the combined ferrate and sulfite treatment

Niu, C., Wang, B., Wang, Z., & Zhang, H. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.148042 · Cited by 12 · see citing works

Superparamagnetic Artificial Cells PLGA-Fe3O4 Micro/Nanocapsules for Cancer Targeted Delivery

Wang, T., & Chang, T. M. S. (2023) · Cancers · doi:10.3390/cancers15245807 · Cited by 12 · see citing works

Emerging roles of small extracellular vesicles in metabolic reprogramming and drug resistance in cancers

Shi, J., Shen, Y. H., & Zhang, J. (2024) · Cancer Drug Resistance · doi:10.20517/cdr.2024.81 · Cited by 13 · see citing works

Glutamine synthetase-negative hepatocellular carcinoma has better prognosis and response to sorafenib treatment after hepatectomy

Shao, M., Tao, Q., Xu, Y., Xu, Q. R., Shu, Y., Chen, Y., Shen, J., Zhou, Y., Wu, Z., Chen, M., et al. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002380 · Cited by 12 · see citing works

Schizandrin ameliorates behavioral disorders in hepatic injury mice via regulation of oxidative stress and neuroinflammation

Yan, T., Liu, B., Li, F., Wu, B., Xiao, F., He, B., & Jia, Y. (2021) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2021.1879847 · Cited by 12 · see citing works

Glutaminase inhibitor CB-839 causes metabolic adjustments in colorectal cancer cells

Spada, M., Piras, C., Leoni, V. P., Casula, M., Simbula, G., Noto, A., Lilliu, K., Kopeć, K. K., Serreli, G., Murgia, F., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-20528-2 · Cited by 11 · see citing works

Engineering biomimetic nanosystem targeting multiple tumor radioresistance hallmarks for enhanced radiotherapy

Wang, S., Cao, H., Zhao, C., Wang, Q., Wang, D., Liu, J., Yang, L., & Liu, J. (2024) · Science China Life Sciences · doi:10.1007/s11427-023-2528-5 · Cited by 11 · see citing works

Interplay between altered metabolism and DNA damage and repair in ovarian cancer

Uboveja, A., & Aird, K. M. (2024) · BioEssays · doi:10.1002/bies.202300166 · Cited by 11 · see citing works

MYCN Amplifications and Metabolic Rewiring in Neuroblastoma

Pouliou, M., Koutsi, M. A., Champezou, L., Giannopoulou, A.-I., Vatsellas, G., Piperi, C., & Agelopoulos, M. (2023) · Cancers · doi:10.3390/cancers15194803 · Cited by 11 · see citing works

Enhancing 223Ra Treatment Efficacy by Anti-β1 Integrin Targeting

Paindelli, C., Casarin, S., Wang, F., Díaz-Gómez, L. A., Zhang, J., Mikos, A. G., Logothetis, C. J., Friedl, P., & Dondossola, E. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.262743 · Cited by 10 · see citing works

Glyceraldehyde-3-phosphate dehydrogenase and glutamine synthetase inhibition in the presence of pro-inflammatory cytokines contribute to the metabolic imbalance of diabetic retinopathy

Shivashankar, G., Lim, J. C.-H., & Acosta, M. L. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108845 · Cited by 10 · see citing works

Glutamine synthetase and hepatocellular carcinoma

Jiang, J., Hu, Y., Fang, D., & Luo, J. (2023) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2023.102248 · Cited by 10 · see citing works

An unmet need for pharmacology: Treatments for radiation-induced gastrointestinal mucositis

Zhou, Y., Li, K., & Adelson, D. L. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116767 · Cited by 9 · see citing works

USP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine γ-lyase

Chen, Y., Xue, F., Wu, Z., Yang, Y., Rao, X., Meng, R., Zhang, S., Dong, X., Xu, S., Wu, G., et al. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01044-3 · Cited by 9 · see citing works

The AST/ALT ratio predicts survival and improves oncological therapy decisions in patients with non-small cell lung cancer receiving immunotherapy with or without radiotherapy

Zhang, Y., Zhang, J., Shang, S., Ma, J., Wang, F., Wu, M., Yu, J., & Chen, D. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1389804 · Cited by 9 · see citing works

Navigating Nongenetic Plasticity in Cancer Drug Resistance

Sun, H., Kumari, N., Melzer, M. E., Backman, V., & Goyal, Y. (2024) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-071924-084617 · Cited by 9 · see citing works

Glutamine: A key player in human metabolism as revealed by hyperpolarized magnetic resonance

dos Santos, K. C., Bertho, G., Baudin, M., & Giraud, N. (2024) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2024.05.003 · Cited by 9 · see citing works

Empowering radiotherapy: Harnessing nanomedicines to enhance radiation response and boost antitumor efficacy

Zhuo, X., Aishajiang, R., Yuan, L., Du, P., Lei, P., Yu, D. N., & Zhang, H. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216140 · Cited by 8 · see citing works

Lipidome analyses reveal radiation induced remodeling of glycerophospholipid unsaturation in lung tumor

He, J., Yuan, Q., Gao, S., Wang, Y., Lai, H., Wang, K., Zhou, X., & Zhang, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1470269 · Cited by 7 · see citing works

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Kim, G. W., Cha, M., Ong, H. T. M., Yoo, J. H., Jeon, Y. H., Lee, S. W., Oh, S. Y., Kang, M., Kim, Y. S., & Kwon, S. H. (2025) · Advanced Science · doi:10.1002/advs.202501553 · Cited by 7 · see citing works

Glutamine synthetase facilitates cancer cells to recover from irradiation-induced G2/M arrest

Peng, Y., Fu, S., Hu, W., Qiu, Y., Zhang, L., Tan, R., & Sun, L. (2019) · Cancer Biology & Therapy · doi:10.1080/15384047.2019.1665394 · Cited by 27 · see citing works

Glutamine metabolism and its roles in tumor radiotherapy by regulating DNA damage repair

Huang, Y., Wang, H., Zhang, S., Jiang, Z., Shen, R., Chang, W., & Jiang, X. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1915673

Glutamine Synthetase and Radiosensitivity in Non-Small Cell Lung Cancer via a STAT5-Regulated Metabolic-DNA Repair Axis

Du, L., Tan, Y., Wang, M., Lai, T., & Zhou, W. (2026) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2026.06.2112

Glutamine metabolism and radiosensitivity: Beyond the Warburg effect

Alden, R. S., Kamran, M. Z., Bashjawish, B., & Simone, B. A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1070514 · Cited by 16 · see citing works

Abstract 7194: Inhibiting glutamine metabolism in combination with radiation disrupts mitochondrial function and impairs homologous recombination

Bright, S. J., Rai, Y., Kolachina, R., Elldakli, H., Wasley, M. D., & Sawakuchi, G. O. (2026) · Cancer Research · doi:10.1158/1538-7445.am2026-7194