The DOI matches its Crossref record; 171 of the 171 references it cites were found in a registry or an index.
Cancer, Oxidative Stress, and Metastasis
Open accessAbstract
Reactive oxygen species (ROS) are highly reactive molecules that arise from a number of cellular sources, including oxidative metabolism in mitochondria. At low levels they can be advantageous to cells, activating signaling pathways that promote proliferation or survival. At higher levels, ROS can damage or kill cells by oxidizing proteins, lipids, and nucleic acids. It was hypothesized that antioxidants might benefit high-risk patients by reducing the rate of ROS-induced mutations and delaying cancer initiation. However, dietary supplementation with antioxidants has generally proven ineffective or detrimental in clinical trials. High ROS levels limit cancer cell survival during certain windows of cancer initiation and progression. During these periods, dietary supplementation with antioxidants may promote cancer cell survival and cancer progression. This raises the possibility that rather than treating cancer patients with antioxidants, they should be treated with pro-oxidants that exacerbate oxidative stress or block metabolic adaptations that confer oxidative stress resistance.
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Citations
Cites
2 retracted
Selective killing of cancer cells by a small molecule targeting the stress response to ROS
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Cited by
Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.001 · Cited by 2,654
The anti-cancer effect of quercetin: molecular implications in cancer metabolism
Reyes-Farias, M., & Carrasco-Pozo, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133177 · Cited by 689
“Oxidative stress has been linked to the hyper-activation of signaling pathways for cell survival, proliferation and migration, as well as metabolic adaptations of tumor microenvironment [67].”
BackgroundReactive Oxygen Species-Related Nanoparticle Toxicity in the Biomedical Field
Yu, Z., Li, Q., Wang, J., Yu, Y., Wang, Y., Zhou, Q., & Li, P. (2020) · Nanoscale Research Letters · doi:10.1186/s11671-020-03344-7 · Cited by 709
Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis
Canli, Ö., Nicolas, A. M., Gupta, J., Finkelmeier, F., Goncharova, O., Pesic, M., Neumann, T., Horst, D., Löwer, M., Sahin, U., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.11.004 · Cited by 359
Oxidative stress and antioxidants in the pathophysiology of malignant melanoma
Obrador, E., Liu-Smith, F., Dellinger, R. W., Salvador, R., Meyskens, F. L., & Estrela, J. M. (2019) · Biological Chemistry · doi:10.1515/hsz-2018-0327 · Cited by 119
Metadata
- Authors
- Gill, J. G., Piskounova, E., & Morrison, S. J.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2016
- Volume
- 81
- Pages
- 163-175
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2574230442
- Cited by
- 266
- References
- 171
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Gill, J. G., Piskounova, E., & Morrison, S. J. (2016). Cancer, Oxidative Stress, and Metastasis. Cold Spring Harbor Symposia on Quantitative Biology. https://doi.org/10.1101/sqb.2016.81.030791
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
